PF 04554878 hydrochloride

Product Name: PF 04554878 hydrochloride
CAS No.: 1073160-26-5
Chemical Name: PF 04554878 hydrochloride
Synonyms: VS6063 hydrochloride;VS 6063 hydrochloride;VS-6063 hydrochloride;Defactinib hydrochlorid;Defactinib hydrochloride;Defactinib (VS-6063) HCl;PF04554878 hydrochloride;PF-04554878 hydrochloride;PF 04554878 hydrochloride;VS60Chemicalbook63hydrochloride
CBNumber: CB72729359
Molecular Formula: C20H22ClF3N8O3S
Formula Weight: 546.95
MOL File: 1073160-26-5.mol

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PF 04554878 hydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO:30.0(Max Conc. mg/mL);54.85(Max Conc. mM)
form: Solid
color: White to off-white
InChIKey: RCHQNUQAHJNRBY-UHFFFAOYSA-N
SMILES: N(C1=NC(NC2C=CC(C(=O)NC)=CC=2)=NC=C1C(F)(F)F)CC1=NC=CN=C1N(C)S(=O)(=O)C.Cl

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3411
Product name: Defactinibhydrochloride
Purity: 98.95%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-3411
Product name: Defactinibhydrochloride
Purity: 98.95%
Packaging: 10mg
Price: $108
Updated: 2021/12/16

ChemScene

Product number: CS-3411
Product name: Defactinibhydrochloride
Purity: 98.95%
Packaging: 50mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-3411
Product name: Defactinibhydrochloride
Purity: 98.95%
Packaging: 100mg
Price: $420
Updated: 2021/12/16

Crysdot

Product number: CD31004648
Product name: Defactinibhydrochloride
Purity: 98+%
Packaging: 5mg
Price: $77
Updated: 2021/12/16

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PF 04554878 hydrochloride Chemical Properties,Usage,Production

Uses

Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

in vivo

Defactinib (VS-6063) doses of 25 mg/kg twice a day or greater statistically significantly inhibits pFAK (Tyr397) at 3 hours, with return of expression noted by 24 hours. Therefore, administration of Defactinib at 25 mg/kg twice a day is selected as the dosing schedule for subsequent therapy experiments. For therapy experiments, female nude mice bearing HeyA8 tumors in the peritoneal cavity are randomly divided into 4 groups (n=10 per group): 1) vehicle orally twice daily and phosphate-buffered saline intraperitoneally weekly (control); 2) Defactinib 25 mg/kg orally twice daily; 3) PTX intraperitoneally weekly; and 4) both VDefactinib 25 mg/kg orally twice daily and PTX intraperitoneally weekly. There is an 87.4% reduction in tumor weight by PTX monotherapy in the HeyA8 model, and combination therapy resulted in the greatest tumor weight reduction, with a 97.9% reduction (P=0.05 compared with PTX). In the SKOV3ip1 model, a 92.7% tumor weight reduction is observed in the combination group compared with PTX (P<0.001)^[1].

References

[1] Kang Y, et al. Role of focal adhesion kinase in regulating YB-1-mediated resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95. DOI:10.1093/jnci/djt210

PF 04554878 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 04554878 hydrochloride Suppliers

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View Lastest Price from PF 04554878 hydrochloride manufacturers

Career Henan Chemical Co

Product: Defactinib hydrochlorid 1073160-26-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1073160-26-5, PF 04554878 hydrochlorideRelated Search:

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Defactinib (VS-6063) hydrochloride

N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide,hydrochloride

Defactinib hydrochlorid

VS60Chemicalbook63hydrochloride

N-Methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide hydrochloride

Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-, hydrochloride (1:1)

Defactinib hydrochloride (VS-6063

1073160-26-5

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