Oxaceprol

Product Name: Oxaceprol
CAS No.: 33996-33-7
Chemical Name: Oxaceprol
Synonyms: NAHP;CO-61;AHP-200;Jonctum;Ac-L-Hyp;AC-HYP-OH;OXACEPROL;trans<;N-AC-L-HYP;Ac-L-Hyp-OH
CBNumber: CB2482503
Molecular Formula: C7H11NO4
Formula Weight: 173.17
MOL File: 33996-33-7.mol

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Oxaceprol Property

Melting point:: 132-133 °C (dec.)(lit.)
alpha: -119 º (c=4 in H2O)
Boiling point:: 303.8°C (rough estimate)
Density: 1.3346 (rough estimate)
vapor pressure: 0Pa at 20℃
refractive index: 1.4490 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO : ≥ 32 mg/mL (184.79 mM)
form: Crystalline Powder
pka: 3.48±0.40(Predicted)
color: White
optical activity: [α]20/D 119°, c = 4 in H2O
Merck: 14,6903
BRN: 84043
InChIKey: BAPRUDZDYCKSOQ-RITPCOANSA-N
LogP: -1.51 at 20℃
CAS DataBase Reference: 33996-33-7(CAS DataBase Reference)
EPA Substance Registry System: L-Proline, 1-acetyl-4-hydroxy-, (4R)- (33996-33-7)

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-36
WGK Germany: 3
F: 10
TSCA: Yes
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 441562
Product name: trans-1-Acetyl-4-hydroxy-L-proline
Purity: ≥98%
Packaging: 10g
Price: $170
Updated: 2024/03/01

Alfa Aesar

Product number: B23767
Product name: N-Acetyl-trans-4-hydroxy-L-proline, 99%
Packaging: 2g
Price: $40.65
Updated: 2024/03/01

Alfa Aesar

Product number: B23767
Product name: N-Acetyl-trans-4-hydroxy-L-proline, 99%
Packaging: 10g
Price: $136
Updated: 2023/06/20

Alfa Aesar

Product number: B23767
Product name: N-Acetyl-trans-4-hydroxy-L-proline
Purity: 99%
Packaging: 5g
Price: $79.2
Updated: 2023/06/20

Alfa Aesar

Product number: B23767
Product name: N-Acetyl-trans-4-hydroxy-L-proline, 99%
Packaging: 50g
Price: $428
Updated: 2021/12/16

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Oxaceprol Chemical Properties,Usage,Production

Chemical Properties

White powder

Originator

Jonctum,Merrell,France,1970

Uses

trans-1-Acetyl-4-hydroxy-L-proline can be used:

In the stereospecific synthesis of 4-fluoroglutamic acid.
To synthesize molecular targets for von Hippel-Lindau (VHL) E3 ubiquitin ligase.
As a precursor to synthesize pseudopoly(amino acids) such as poly(trans-4-hydroxy-4-acyl-L-proline ester) and a biodegradable polymer, poly(lactic acid-glycolic acid-4-hydroxyproline).

Manufacturing Process

16.7 g (0.127 mol) of L-hydroxyproline are dissolved in 400 ml of pure boiling acetic acid. With vigorous boiling and agitation, a mixture of 13.7 ml (0.154 mol) of rectified acetic anhydride and 250 ml of pure acetic acid is added during 25 minutes. Without discontinuing the stirring, contents of the flask are cooled by simply causing fresh air to circulate externally round the flask until the temperature of the mixture is reduced to about 35°C. The acetic acid is removed by using a rotary evaporator without exceeding 35°C under a vacuum of about 15 mm Hg. After one hour, 20 ml of anhydrous toluene are added, then 10 ml of anhydrous acetone; the mixture is homogenized and concentrated again as above during 30 minutes. Then 25 ml of acetone are added again, and subsequently 20 ml of toluene, the product being concentrated again; gradually the solution is converted into an amber-colored crystallized paste. Finally, 30 ml of acetone are added to the residue, and stirring is carried out until the oily fraction surrounding the crystals is dissolved. The product is then cooled in an ice chamber, centrifuged, washed with anhydrous acetone and eventually dried, After recrystallization from acetone, crystals are obtained, melting point 132°C.

Therapeutic Function

Antirheumatic

Flammability and Explosibility

Not classified

Oxaceprol Preparation Products And Raw materials

Raw materials

Preparation Products

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Oxaceprol Suppliers

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View Lastest Price from Oxaceprol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Acetyl-L-hydroxyproline 33996-33-7
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-26

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Oxaceprol 33996-33-7
Price: US $79.00-38.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-11-21

Hebei Weibang Biotechnology Co., Ltd

Product: Oxaceprol 33996-33-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

33996-33-7, OxaceprolRelated Search:

Oxaceprol TRANS-1-BENZOYL-4-HYDROXY-L-PROLINE METHYL ESTER N-Tetradecanoyl-4-hydroxy-L-proline TRANS-1-BENZOYL-4-HYDROXY-L-PROLINE Dipalmitoyl hydroxyproline N-Acetyl-L-Hydroxyproline L-Hydroxyproline L-Proline 1-(4-FLUOROBENZOYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID H-GLY-ALA-HYP-OH H-GLY-PRO-HYP-OH H-PRO-HYP-OH H-GLY-HYP-OH GLY-PRO-HYDROXY-PRO ACETATE SALT 1-(2-FURYLCARBONYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID METHYL 1-(4-FLUOROBENZOYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLATE Z-PRO-HYP-OH O-acetyl-L-hydroxyproline homopolymer,POLY-O-ACETYL-L-HYDROXYPROLINE)

TRANS-1-ACETYL-4-HYDROXY-L-PROLINE

N-ACETYLHYDROXY-L-PROLINE

N-ACETYL-L-HYDROXYPROLINE

N-ALPHA-ACETYL-TRANS-4-HYROXY-L-PYROLLIDINE

N-ALPHA-ACETYL-L-4-TRANS-HYDROXYPROLINE

N-ALPHA-ACETYL-L-HYROXYPROLINE

(-)-1-Acetyl-4β-hydroxy-L-proline

(4R)-1-Acetyl-4-hydroxy-L-proline

trans-1-Acetyl-4-hydroxy-L-proline 99%

trans-1-Acetyl-4-hydroxy-L-proline, >=98%

Ac-Hyp-OH≥ 95% (TLC)

Nα-Acetyl-L-4-trans-hydroxyproline

<I>trans</I>-1-Acetyl-4-hydroxy-<SC>L</SC>-proline

Ac-L-Hyp

(4R,2S)-1-ACETYL-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID

ACETYL-L-4-HYDROXYPROLINE

ACETYL-4-HYDROXY-L-PROLINE

AC-HYDROXYPROLINE

AC-HYP-OH

(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

OXACEPROL

N-ACETYL-4-HYDROXY-L-PROLINE

N-AC-L-HYP

trans-l-prolin

(R)-N-Acetyl-4-hydroxy-L-proline

N-Acetyl-4-hydroxyproline

N-Acetylhydroxyproline

N-Acetyl-trans-4-hydroxy-L-proline

AHP-200

CO-61

Jonctum

N-Acetyl-L-hydroxyproline;trans-1-Acetyl-4-hydroxy-L-proline;1-Acetyl-4-hydroxy-2-pyrrolidinecarboxylic acid;AHP-200;CO-61;Jonctum;Oxaceprol

1-Acetyl-4-hydroxy-2-pyrrolidinecarboxylic acid

Oxaceprol (trans-1-Acetyl-4-hydroxy-L-proline,monhydrate)

Acetyl-trans-4-hydroxy-L-proline

Hyp4001Ac-Hyp-Oh

L-Proline, 1-acetyl-4-hydroxy-, (4R)- (9CI)

(2S,4R)-N-ACETYL-4-HYDROXY-L-PROLINE

N-Acetyl-L- 4-Hydroxyproline

(2S,4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid

Ac-L-Hyp-OH

N-alpha-Acetyl-L-4-hydroxyproline

N-Acetyl-L-Hydroproline

L-Proline, 1-acetyl-4-hydroxy-, (4R)-

Oxaceprol USP/EP/BP

OxaceprolQ: What is Oxaceprol Q: What is the CAS Number of Oxaceprol Q: What is the storage condition of Oxaceprol Q: What are the applications of Oxaceprol

<I>trans<

NAHP

Oxaceprol (N-acetyl-L-hydroxyproline)

33996-33-7

33966-33-7

33996-33-8

C7H11NO4

Peptide Synthesis

Proline Derivatives

Specialty Synthesis

Unnatural Amino Acid Derivatives

Hydroxyproline [Hyp]