3,4-(METHYLENEDIOXY)BUTYROPHENONE
- Product Name
- 3,4-(METHYLENEDIOXY)BUTYROPHENONE
- CAS No.
- 63740-97-6
- Chemical Name
- 3,4-(METHYLENEDIOXY)BUTYROPHENONE
- Synonyms
- 3'-Chlorobutanophenone;1-(1,3-Benzodioxol-5-yl)-;5-Butyryl-1,3-benzodioxole;1,3-BENZODIOXOLE-5-BUTYROYL;3,4-METHYLENEDIOXYPHENYL-BUTONE;3,4-(METHYLENEDIOXY)BUTYROPHENONE;1-(1,3-Benzodioxol-5-yl)-1-butanone;1-(1,3-benzodioxol-5-yl)butan-1-one;1-(Benzod1,3dioxol-5-yl)-1-butanone;3',4'-(Methylenedioxy)butyrophenone
- CBNumber
- CB2482644
- Molecular Formula
- C11H12O3
- Formula Weight
- 192.21
- MOL File
- 63740-97-6.mol
3,4-(METHYLENEDIOXY)BUTYROPHENONE Property
- Melting point:
- 47-49°C
- Boiling point:
- 319.3±31.0 °C(Predicted)
- Density
- 1.163±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- BRN
- 168758
- CAS DataBase Reference
- 63740-97-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M304010
- Product name
- 3’,4’-(Methylenedioxy)butyrophenone
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- M304010
- Product name
- 3’,4’-(Methylenedioxy)butyrophenone
- Packaging
- 5g
- Price
- $925
- Updated
- 2021/12/16
- Product number
- 176341
- Product name
- 1-(1,3-Benzodioxol-5-yl)-1-butanone
- Packaging
- 10g
- Price
- $1170
- Updated
- 2021/12/16
- Product number
- CHM0022752
- Product name
- 3,4-(METHYLENEDIOXY)BUTYROPHENONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1593.9
- Updated
- 2021/12/16
- Product number
- 9748AB
- Product name
- 1-(Benzo[d][1,3]dioxol-5-yl)butan-1-one
- Packaging
- 25g
- Price
- $257
- Updated
- 2021/12/16
3,4-(METHYLENEDIOXY)BUTYROPHENONE Chemical Properties,Usage,Production
Chemical Properties
3,4-(METHYLENEDIOXY)BUTYROPHENONE is White to cream solid
Uses
3,4-(METHYLENEDIOXY)BUTYROPHENONE is used in the synthesis of α-propylpiperonylamine and analogs.
Uses
Used in the synthesis of α-propylpiperonylamine and analogs.
Synthesis
106-31-0
274-09-9
63740-97-6
To a pre-dried two-necked round-bottomed flask were added 1,2-methylenedioxybenzene (piperylene ring, 2.0 g, 16.37 mmol), 1,2-dichloroethane (7 mL) and n-butyric anhydride (3.2 mL, 19.6 mmol). The reaction mixture was cooled to -10 °C and boron trifluoride ethyl ether complex (BF3-Et2O, 6.78 g, 47.7 mmol) was slowly added dropwise over 15 min while keeping the reaction temperature between -5 °C and 0 °C. After the dropwise addition, the reaction mixture was continued to be stirred at -5 °C for 3 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium acetate solution, and the organic layer was separated and washed sequentially with 5% aqueous sodium hydroxide solution (7 mL) and deionized water. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography with hexane/ethyl acetate (10:1, v/v) as eluent to afford the target compound 3,4-(methylenedioxy)phenylbutanone (1.34 g, 85% yield). 1H NMR (400 MHz, CDCl3) δ: 7.52 (dd, J = 8.1, 1.6 Hz, 1H), 7.40 (d, J = 8.1 Hz, 1H), 6.80 (d, J = 8.1 Hz, 1H), 5.99 (s, 1H), 2.82 (t, J = 7.3 Hz, 2H), 1.70 (h, J = 7.4 Hz, 2H ), 0.95 (t, J = 7.4 Hz, 3H). 13C NMR (100 MHz, CDCl3) δ: 198.4, 151.5, 148.1, 132.0, 124.1, 107.8, 107.7, 101.7, 40.2, 18.0, 13.8. HRMS-ESI-MS (m/z) [M + H]+: calculated value C11H13O3: 193.0865; measured value: 193.0867.
References
[1] Organic Process Research and Development, 2002, vol. 6, # 1, p. 54 - 63
[2] Tetrahedron, 2013, vol. 69, # 1, p. 268 - 273
[3] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 13, p. 2668 - 2674
3,4-(METHYLENEDIOXY)BUTYROPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-(METHYLENEDIOXY)BUTYROPHENONE manufacturers
- Product
- 3,4-(METHYLENEDIOXY)BUTYROPHENONE 63740-97-6
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-07
- Product
- 3,4-(METHYLENEDIOXY)BUTYROPHENONE 63740-97-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2022-09-26
- Product
- 3,4-(METHYLENEDIOXY)BUTYROPHENONE 63740-97-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27