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1,4-Dichlorophthalazine

Product Name
1,4-Dichlorophthalazine
CAS No.
4752-10-7
Chemical Name
1,4-Dichlorophthalazine
Synonyms
1,4-Dichlorophtalazine;1,4-Dichloro-2,3-benzodiazine;Dichlorophthalazine;1,4-Dichloropyrazine;1,4-DICHLOROPHALAZINE;1,4-DICHLOROPHTHALAZINE;Phthalazine, 1,4-dichloro-;1,4-Dichlorophthalazine>1,4-Dichlorophthalazine,98%;JR-8370, 1,4-Dichlorophthalazine, 97%
CBNumber
CB2483520
Molecular Formula
C8H4Cl2N2
Formula Weight
199.04
MOL File
4752-10-7.mol
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1,4-Dichlorophthalazine Property

Melting point:
160-162 °C (lit.)
Boiling point:
397.3±22.0 °C(Predicted)
Density 
1.486±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Chloroform, Methanol
pka
-0.44±0.30(Predicted)
form 
Powder or Crystalline Powder
color 
White to yellow
Water Solubility 
Sparingly soluble in water.(0.26 g/L) (25°C),
Sensitive 
Moisture Sensitive
InChI
InChI=1S/C8H4Cl2N2/c9-7-5-3-1-2-4-6(5)8(10)12-11-7/h1-4H
InChIKey
ODCNAEMHGMYADO-UHFFFAOYSA-N
SMILES
C1(Cl)C2=C(C=CC=C2)C(Cl)=NN=1
CAS DataBase Reference
4752-10-7(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
126020
Product name
1,4-Dichlorophthalazine
Purity
95%
Packaging
5g
Price
$159.16
Updated
2025/07/31
Sigma-Aldrich
Product number
126020
Product name
1,4-Dichlorophthalazine
Purity
95%
Packaging
1g
Price
$44.6
Updated
2023/06/20
TCI Chemical
Product number
D3749
Product name
1,4-Dichlorophthalazine
Purity
>98.0%(GC)
Packaging
1g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
D3749
Product name
1,4-Dichlorophthalazine
Purity
>98.0%(GC)
Packaging
5g
Price
$113
Updated
2025/07/31
TRC
Product number
D436165
Product name
1,4-Dichlorophthalazine
Packaging
1g
Price
$55
Updated
2021/12/16
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1,4-Dichlorophthalazine Chemical Properties,Usage,Production

Uses

1,4-Dichlorophthalazine was used as starting reagent in the synthesis of series of 4-aryl-1-(4-methylpiperazin-1-yl)phthalazines. It was used as coupling reagent in the synthesis of novel soluble polymer-bound ligand. It was often used as building block in medicinal chemistry synthesis.

Uses

1,4-Dichlorophthalazine Oftens used building block in medicinal chemistry synthesis.1,2

Synthesis Reference(s)

Canadian Journal of Chemistry, 43, p. 2708, 1965 DOI: 10.1139/v65-379

Synthesis

1445-69-8

4752-10-7

General procedure for the synthesis of 1,4-dichlorophthalazine from phthaloyl hydrazine: phthaloyl hydrazine (1.68 g, 10 mmol) was added to a stirred solution of phosphoryl chloride (15 ml). The mixture was heated to 110°C and kept for 1 hour. After completion of the reaction (monitored by TLC), the reaction mixture was cooled to room temperature. The mixture was slowly added dropwise to crushed ice and stirred for 10 minutes. Subsequently, the mixture was filtered through a Brinell funnel. The filter cake was washed to neutrality with distilled water and dried in vacuum. 1,4-Dichlorophthalazine (1.85 g, 90.1% yield) was finally obtained as a white solid.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 4, p. 1236 - 1238
[2] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 235 - 244
[3] Chemical Biology and Drug Design, 2013, vol. 81, # 5, p. 591 - 599
[4] New Journal of Chemistry, 2016, vol. 40, # 7, p. 6070 - 6076
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 6, p. 1576 - 1579

1,4-Dichlorophthalazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-Dichlorophthalazine Suppliers

Americas 1 Canada 1 China 204 Europe 1 France 2 Germany 2 India 5 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 4 United States 17 Global 240
Dalton Chemical Laboratories, Inc.
Tel
--
Fax
--
Email
chemist@dalton.com
Country
Canada
ProdList
965
Advantage
78
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View Lastest Price from 1,4-Dichlorophthalazine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1,4-Dichlorophthalazine 4752-10-7
Price
US $1.00-22.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-08-15
Shanghai Rlavie Technology Co ltd
Product
1,4-Dichlorophthalazine 4752-10-7
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
200kgs/month
Release date
2021-11-04
Career Henan Chemical Co
Product
1,4-Dichlorophthalazine 4752-10-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-21

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