BMS-1166

ChemicalBook > CAS DataBase List > BMS-1166

Product Name: BMS-1166
CAS No.: 1818314-88-3
Chemical Name: BMS-1166
Synonyms: BMS-1166;PD-1/PD-L1-IN1;BMS-1166 (PD-1/PD-L1-IN1);PD-1/PD-L1-IN1 BMS-1166;BMS-1166 (Synonyms: PD-1/PD-L1-IN1);BMS 1166Q: What is BMS 1166 Q: What is the CAS Number of BMS 1166;Inhibitor,BMS1166,BMS 1166,activation,immune,cell,interaction,BMS-1166,dimerization,checkpoint,inhibit;D-Proline, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-, (4R)-;(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid
CBNumber: CB24843928
Molecular Formula: C36H33ClN2O7
Formula Weight: 641.11
MOL File: 1818314-88-3.mol

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BMS-1166 Property

Boiling point:: 817.5±65.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
form: A crystalline solid
pka: 2.03±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0022454
Product name: BMS-1166
Purity: 99.86%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0022454
Product name: BMS-1166
Purity: 99.86%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0022454
Product name: BMS-1166
Purity: 99.86%
Packaging: 25mg
Price: $1750
Updated: 2021/12/16

ChemScene

Product number: CS-0022454
Product name: BMS-1166
Purity: 99.86%
Packaging: 50mg
Price: $2750
Updated: 2021/12/16

ChemScene

Product number: CS-0022454
Product name: BMS-1166
Purity: 99.86%
Packaging: 100mg
Price: $3950
Updated: 2021/12/16

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BMS-1166 Chemical Properties,Usage,Production

Biological Activity

BMS-1166 is a novel and potent inhibitor of PD-1/PD-L1 interaction with IC50 of 1.4 nM.

in vitro

BMS-1166 had low toxicity to the tested cell lines and prevented the interaction of soluble PD-L1 with PD-1 receptors expressed on the cell surface. It attenuates the inhibitory effect of PD-L1 on T cell receptor-mediated T lymphocyte activation.

target

Target	Value
PD-1/PD-L1 interaction ()	1.4 nM

BMS-1166 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-1166 Suppliers

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1818314-88-3, BMS-1166Related Search:

PD-1/PD-L1-IN1

BMS-1166 (Synonyms: PD-1/PD-L1-IN1)

D-Proline, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-, (4R)-

PD-1/PD-L1-IN1 BMS-1166

BMS-1166 (PD-1/PD-L1-IN1)

BMS 1166Q: What is BMS 1166 Q: What is the CAS Number of BMS 1166

(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid

BMS-1166

Inhibitor,BMS1166,BMS 1166,activation,immune,cell,interaction,BMS-1166,dimerization,checkpoint,inhibit

1818314-88-3

C36H33ClN2O7