BMS-1166
- Product Name
- BMS-1166
- CAS No.
- 1818314-88-3
- Chemical Name
- BMS-1166
- Synonyms
- BMS-1166;PD-1/PD-L1-IN1;BMS-1166 ，S8859;BMS-1166, 10 mM in DMSO;BMS-1166 (PD-1/PD-L1-IN1);PD-1/PD-L1-IN1 BMS-1166;BMS-1166 (Synonyms: PD-1/PD-L1-IN1);BMS 1166Q: What is BMS 1166 Q: What is the CAS Number of BMS 1166;Inhibitor,BMS1166,BMS 1166,activation,immune,cell,interaction,BMS-1166,dimerization,checkpoint,inhibit;D-Proline, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-, (4R)-
- CBNumber
- CB24843928
- Molecular Formula
- C36H33ClN2O7
- Formula Weight
- 641.11
- MOL File
- 1818314-88-3.mol
BMS-1166 Property
- Boiling point:
- 817.5±65.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- form
- A crystalline solid
- pka
- 2.03±0.40(Predicted)
- color
- White to off-white
- InChIKey
- QBXVXKRWOVBUDB-GRKNLSHJSA-N
- SMILES
- C(O)(=O)[C@H]1C[C@@H](O)CN1CC1=CC(Cl)=C(OCC2=CC=CC(C3=CC=C4OCCOC4=C3)=C2C)C=C1OCC1=CC=CC(C#N)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0022454
- Product name
- BMS-1166
- Purity
- 99.86%
- Packaging
- 5mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0022454
- Product name
- BMS-1166
- Purity
- 99.86%
- Packaging
- 10mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0022454
- Product name
- BMS-1166
- Purity
- 99.86%
- Packaging
- 25mg
- Price
- $1750
- Updated
- 2021/12/16
- Product number
- CS-0022454
- Product name
- BMS-1166
- Purity
- 99.86%
- Packaging
- 50mg
- Price
- $2750
- Updated
- 2021/12/16
- Product number
- CS-0022454
- Product name
- BMS-1166
- Purity
- 99.86%
- Packaging
- 100mg
- Price
- $3950
- Updated
- 2021/12/16
BMS-1166 Chemical Properties,Usage,Production
Uses
BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2].
Biological Activity
BMS-1166 is a novel and potent inhibitor of PD-1/PD-L1 interaction with IC50 of 1.4 nM.
in vitro
BMS-1166 had low toxicity to the tested cell lines and prevented the interaction of soluble PD-L1 with PD-1 receptors expressed on the cell surface. It attenuates the inhibitory effect of PD-L1 on T cell receptor-mediated T lymphocyte activation.
target
| Target | Value |
| PD-1/PD-L1 interaction () | 1.4 nM |
References
[1] Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867. DOI:10.1021/acs.jmedchem.7b00293
[2] Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181. DOI:10.18632/oncotarget.20050