ChemicalBook > CAS DataBase List > MDL-800 (MDL800)

MDL-800 (MDL800)

Product Name: MDL-800 (MDL800)
CAS No.: 2275619-53-7
Chemical Name: MDL-800 (MDL800)
Synonyms: Benzoic acid, 2-[[(5-bromo-4-fluoro-2-methylphenyl)amino]sulfonyl]-5-[[(3,5-dichlorophenyl)sulfonyl]amino]-, methyl ester;MDL-800 (MDL800);Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate
CBNumber: CB24845018
Molecular Formula: C21H16BrCl2FN2O6S2
Formula Weight: 626.3
MOL File: 2275619-53-7.mol

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MDL-800 (MDL800) Property

Boiling point:: 714.8±70.0 °C(Predicted)
Density: 1.710±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to at least 10 mg/ml with warming)
form: solid
pka: 4.96±0.10(Predicted)
color: White
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: BISN0090
Product name: MDL-800
Purity: 99%
Packaging: 1mg
Price: $399
Updated: 2021/12/16

Apolloscientific

Product number: BISN0090
Product name: MDL-800
Purity: 99%
Packaging: 5mg
Price: $704
Updated: 2021/12/16

Apolloscientific

Product number: BISN0090
Product name: MDL-800
Purity: 99%
Packaging: 10mg
Price: $1052
Updated: 2021/12/16

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MDL-800 (MDL800) Chemical Properties,Usage,Production

Description

MDL-800 (2275619-53-7) is an allosteric activator of SIRT6 (EC50 = 10.3 μM).1 It specifically activates the deacetylase (H3K9ac and H3K56ac) activity of SIRT6 – inactive against SIRT1,3,4 and HDACs 1-11 with 10x less activity against SIRT2,5,7. It inhibited the growth of human hepatocarcinoma cells (HCC) via the tumor suppressor deacetylase (H3K9ac and H3K56ac) via cell-cycle arrest and showed efficacy in a xenograft model of HCC.? MDL-800 improved the genetic stability of old-murine-derived iPSCs via activation of NHEJ and BER DNA repair pathways suggesting promise in treating age-related diseases via iPSC-based therapies.2 MDL-800 inhibited the proliferation of 12 non-small cell lung carcinoma cell lines with IC50 values of 21.5 to 34.5 μM.3 It also enhanced the effects of EGFR kinase inhibitors in Osimertinib-resistant HCC827 and PC9 cells as well as in patient-derived primary tumor cells.3

References

[1] ZHIMIN HUANG. Identification of a cellularly active SIRT6 allosteric activator[J]. Nature chemical biology, 2018, 14 12: 1118-1126. DOI:10.1038/s41589-018-0150-0
[2] YU CHEN. The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells[J]. Aging Cell, 2020, 19 8. DOI:10.1111/acel.13185
[3] JIA-LIN SHANG. MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer[J]. Acta Pharmacologica Sinica, 2020, 42 1: 120-131. DOI:10.1038/s41401-020-0442-2

MDL-800 (MDL800) Preparation Products And Raw materials

Raw materials

Preparation Products

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2275619-53-7, MDL-800 (MDL800)Related Search:

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MDL-800 (MDL800)

Benzoic acid, 2-[[(5-bromo-4-fluoro-2-methylphenyl)amino]sulfonyl]-5-[[(3,5-dichlorophenyl)sulfonyl]amino]-, methyl ester

Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate

2275619-53-7

C21H16BrCl2FN2O6S2