Amino-Tri-(carboxyethoxymethyl)-methane
- Product Name
- Amino-Tri-(carboxyethoxymethyl)-methane
- CAS No.
- 174362-95-9
- Chemical Name
- Amino-Tri-(carboxyethoxymethyl)-methane
- Synonyms
- Amino-Tri-(carboxyethoxymethyl)-methane;Tri[(2-carboxyethoxy)methyl](amino)methane;Amino-Tri-(carboxyethoxymethyl)-methane (HCl);Amino-Tri-(carboxyethoxymethyl)-methane, TFA salt;3,3'-((2-amino-2-((2-carboxyethoxy)methyl)propane-1,3-diyl)bis(oxy))dipropionic acid;3,3’-[[2-Amino-2-[(2-carboxyethoxy)methyl]propane-1,3-diyl]bis(oxy)]dipropanoic Acid;Propanoic acid, 3,3'-[[2-amino-2-[(2-carboxyethoxy)methyl]-1,3-propanediyl]bis(oxy)]bis-
- CBNumber
- CB24849531
- Molecular Formula
- C13H23NO9
- Formula Weight
- 337.32
- MOL File
- 174362-95-9.mol
Amino-Tri-(carboxyethoxymethyl)-methane Property
- Boiling point:
- 620.2±55.0 °C(Predicted)
- Density
- 1.350±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- low melting solid
- pka
- 3.74±0.10(Predicted)
- color
- Colourless
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-23952
- Product name
- Amino-Tri-(carboxyethoxymethyl)-methane
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- BP-23952
- Product name
- Amino-Tri-(carboxyethoxymethyl)-methane
- Purity
- 98%
- Packaging
- 250mg
- Price
- $560
- Updated
- 2021/12/16
Amino-Tri-(carboxyethoxymethyl)-methane Chemical Properties,Usage,Production
Description
Amino-Tri-(carboxyethoxymethyl)-methane is a branched molecule that is reactive towards carboxylic acids in the presence of HATU. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Amino-Tri-(carboxyethoxymethyl)-methan is a cleavable PEG-based ADC linker that can be used to synthesize antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| PEGs
| Cleavable
|