STAUROSPORINE
- Product Name
- STAUROSPORINE
- CAS No.
- 62996-74-1
- Chemical Name
- STAUROSPORINE
- Synonyms
- STSP;AM-2282;Staurosporin;Stauroporine;CBR113;CS-2206;Sporosin;CGP 39360;CCRIS 3272;Astrosporin
- CBNumber
- CB2486697
- Molecular Formula
- C28H26N4O3
- Formula Weight
- 466.54
- MOL File
- 62996-74-1.mol
STAUROSPORINE Property
- Melting point:
- 270°C
- alpha
- D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
- Boiling point:
- 677.5±55.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- RTECS
- KD5084000
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble
- form
- White to pale yellow solid
- pka
- 14.25±0.70(Predicted)
- color
- Off white to pale yellow
- Water Solubility
- Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.
- BRN
- 1060573
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
- InChIKey
- HKSZLNNOFSGOKW-WIFUGMKFSA-N
- CAS DataBase Reference
- 62996-74-1
Safety
- Hazard Codes
- Xn,T,Xi
- Risk Statements
- 40-45-36/37/38-46
- Safety Statements
- 36/37-53-36-26-45
- RIDADR
- UN 2811 6.1 / PGII
- WGK Germany
- 2
- F
- 8-10
- HazardClass
- 3
- HS Code
- 29419090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- S5921
- Product name
- Staurosporine from Streptomyces sp.
- Purity
- for molecular biology, ≥95% (HPLC)
- Packaging
- 0.1mg
- Price
- $307
- Updated
- 2024/03/01
- Product number
- S5921
- Product name
- Staurosporine from Streptomyces sp.
- Purity
- for molecular biology, ≥95% (HPLC)
- Packaging
- 0.5mg
- Price
- $883
- Updated
- 2024/03/01
- Product number
- S4400
- Product name
- Staurosporine from Streptomyces sp.
- Purity
- ≥98% (HPLC), film
- Packaging
- 0.1mg
- Price
- $223.2
- Updated
- 2024/03/01
- Product number
- S4400
- Product name
- Staurosporine from Streptomyces sp.
- Purity
- ≥98% (HPLC), film
- Packaging
- 0.5mg
- Price
- $802
- Updated
- 2024/03/01
- Product number
- 569397
- Product name
- Staurosporine, Streptomyces sp.
- Purity
- Staurosporine,CAS62996-74-,isacell-permeable,potent,reversible,ATP-compe
- Packaging
- 100μg
- Price
- $159
- Updated
- 2024/03/01
STAUROSPORINE Chemical Properties,Usage,Production
Description
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-
Chemical Properties
Light Yellow Solid
Occurrence
A complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.
Uses
Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.
Uses
Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.
Definition
ChEBI: Staurosporine is an indolocarbazole alkaloid and an organic heterooctacyclic compound. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a geroprotector, a bacterial metabolite and an apoptosis inducer. It is a conjugate base of a staurosporinium.
General Description
A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.
Biological Activity
Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Biochem/physiol Actions
Reversible: yes
storage
+4°C
References
1) Omura et al. (1977) A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization; J. Antibiot., 30 275 2) Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases; Trends in Pharmacological Science 10 218
STAUROSPORINE Preparation Products And Raw materials
Raw materials
Preparation Products
STAUROSPORINE Suppliers
- Tel
- --
- Fax
- --
- info@bioaustralis.com
- Country
- Australia
- ProdList
- 76
- Advantage
- 58
- Tel
- --
- Fax
- --
- admin@linksbank.net
- Country
- Australia
- ProdList
- 44
- Advantage
- 75
View Lastest Price from STAUROSPORINE manufacturers
- Product
- staurosporine 62996-74-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- 20kg/month
- Release date
- 2021-06-10
- Product
- STAUROSPORINE 62996-74-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 MT
- Release date
- 2024-11-14
- Product
- STAUROSPORINE 62996-74-1
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03