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STAUROSPORINE

Product Name
STAUROSPORINE
CAS No.
62996-74-1
Chemical Name
STAUROSPORINE
Synonyms
STSP;AM-2282;Staurosporin;Stauroporine;CBR113;CS-2206;Sporosin;CGP 39360;CCRIS 3272;Astrosporin
CBNumber
CB2486697
Molecular Formula
C28H26N4O3
Formula Weight
466.54
MOL File
62996-74-1.mol
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STAUROSPORINE Property

Melting point:
270°C
alpha 
D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
Boiling point:
677.5±55.0 °C(Predicted)
Density 
1.56±0.1 g/cm3(Predicted)
RTECS 
KD5084000
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
White to pale yellow solid
pka
14.25±0.70(Predicted)
color 
Off white to pale yellow
Water Solubility 
Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.
BRN 
1060573
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey
HKSZLNNOFSGOKW-WIFUGMKFSA-N
CAS DataBase Reference
62996-74-1
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
40-45-36/37/38-46
Safety Statements 
36/37-53-36-26-45
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
2
F 
8-10
HazardClass 
3
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S5921
Product name
Staurosporine from Streptomyces sp.
Purity
for molecular biology, ≥95% (HPLC)
Packaging
0.1mg
Price
$307
Updated
2024/03/01
Sigma-Aldrich
Product number
S5921
Product name
Staurosporine from Streptomyces sp.
Purity
for molecular biology, ≥95% (HPLC)
Packaging
0.5mg
Price
$883
Updated
2024/03/01
Sigma-Aldrich
Product number
S4400
Product name
Staurosporine from Streptomyces sp.
Purity
≥98% (HPLC), film
Packaging
0.1mg
Price
$223.2
Updated
2024/03/01
Sigma-Aldrich
Product number
S4400
Product name
Staurosporine from Streptomyces sp.
Purity
≥98% (HPLC), film
Packaging
0.5mg
Price
$802
Updated
2024/03/01
Sigma-Aldrich
Product number
569397
Product name
Staurosporine, Streptomyces sp.
Purity
Staurosporine,CAS62996-74-,isacell-permeable,potent,reversible,ATP-compe
Packaging
100μg
Price
$159
Updated
2024/03/01
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STAUROSPORINE Chemical Properties,Usage,Production

Description

Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively. However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.

Chemical Properties

Light Yellow Solid

Occurrence

A complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.

Uses

Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.

Uses

Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.

Definition

ChEBI: Staurosporine is an indolocarbazole alkaloid and an organic heterooctacyclic compound. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a geroprotector, a bacterial metabolite and an apoptosis inducer. It is a conjugate base of a staurosporinium.

General Description

A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.

Biological Activity

Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Reversible: yes

storage

+4°C

References

1) Omura et al. (1977) A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization; J. Antibiot., 30 275 2) Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases; Trends in Pharmacological Science 10 218

STAUROSPORINE Preparation Products And Raw materials

Raw materials

Preparation Products

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STAUROSPORINE Suppliers

Australia 2 Belgium 2 Canada 3 China 266 Czech Republic 1 France 2 Germany 10 India 6 Japan 2 Poland 1 South Africa 1 Spain 2 Switzerland 3 The Netherlands 1 United Kingdom 15 United States 48 Global 365
Pharma Affiliates
Tel
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Email
@pharmaffiliates.com
Country
India
ProdList
6754
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58
Clearsynth Labs
Tel
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Fax
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Email
fo@clearsynth.com
Country
India
ProdList
3887
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58
SynZeal Research Pvt Ltd
Tel
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Fax
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Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
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Fax
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Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
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58
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
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58
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View Lastest Price from STAUROSPORINE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
staurosporine 62996-74-1
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
20kg/month
Release date
2021-06-10
Hebei Weibang Biotechnology Co., Ltd
Product
STAUROSPORINE 62996-74-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 MT
Release date
2024-11-14
Henan Fengda Chemical Co., Ltd
Product
STAUROSPORINE 62996-74-1
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-03

62996-74-1, STAUROSPORINERelated Search:

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  • Staurosporine, Antibiotic AM-2282
  • (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
  • AM-2282
  • Antibiotic 230
  • CGP 39360
  • Staurosporin
  • [9S-(9alpha,10beta,11beta,13alpha)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-1m]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
  • (9S,10α,11α,13β)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
  • STAUROSPORINE, STREPTOMYCES SPECIES
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  • [9S,10α,11α,13β,(+)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
  • Staurosporine,98%
  • Stauroporine
  • [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
  • Staurosporine,AM-2282,STS
  • yT5720idec Monophosphorothioate, Rp-IsoMer, TriethylaMMoniuM SaltuM Saltnoic acid salt
  • Staurosporine(CGP 41251)
  • CBR113
  • STSP
  • ANTIBIOTIC M 193
  • ANTIBIOTIC AM-2282
  • [9S-(9A,10B,11B,13A)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-1M]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE
  • 2,3,10,11,12,13-HEXAHYDRO-10R-METHOXY-9S-METHYL-11R-METHYLAMINO-9S,13R-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1 ONE
  • STAUROSPORINE FROM STREPTOMYCES SP.
  • STAUROSPORINE READY-MADE SOLUTION
  • STAUROSPORINE FROM STREPTOMYCES SP., PGE WITH 250 UG
  • STAUROSPORINE, 99+%.
  • STAUROSPORINE FROM STREPTOMYCES SP MOLECULAR BIOLOGY REAGENT 98+%
  • AM 2282, M 193
  • 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
  • InSolution Staurosporine, Streptomyces sp
  • Staurosporine, 98%, from Streptomyces sp.
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  • STAUROSPORINE USP/EP/BP
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  • US-DMF No.: 034763
  • Star spore fungus
  • (5S,6R,7R,9R)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one
  • Sporosin
  • Staurosporine (PKC inhibitors)
  • (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14(5H)-one
  • Astrosporin
  • CCRIS 3272
  • Star spore fungicide
  • 62996-74-1
  • C28H26N4O3
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