ChemicalBook > CAS DataBase List > 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol

3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol

Product Name
3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
CAS No.
1198357-79-7
Chemical Name
3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
Synonyms
ETP 45658;ETP-45658, 10 mM in DMSO;3-(1-Methyl-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol;3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol;Phenol, 3-[1-methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-;Inhibitor,PI3K,breast,DNA-PK,Mammalian target of Rapamycin,DNA-dependent protein kinase,mTOR,inhibit,Phosphoinositide 3-kinase,ETP-45658,cancer
CBNumber
CB24902630
Molecular Formula
C16H17N5O2
Formula Weight
311.34
MOL File
1198357-79-7.mol
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3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol Property

Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
9.18±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Tocris
Product number
4702
Product name
ETP45658
Purity
≥98%(HPLC)
Packaging
10
Price
$205
Updated
2021/12/16
Tocris
Product number
4702
Product name
ETP45658
Purity
≥98%(HPLC)
Packaging
50
Price
$865
Updated
2021/12/16
TRC
Product number
E936915
Product name
ETP45658
Packaging
5mg
Price
$115
Updated
2021/12/16
TRC
Product number
E936915
Product name
ETP45658
Packaging
10mg
Price
$185
Updated
2021/12/16
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3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol Chemical Properties,Usage,Production

Uses

ETP 45658 is a potent and selective inhibitor of phosphoinositol 3-kinase and demonstrates mechanism of action in tumor cells, inhibitors of mTOR kinase as antiviral agents.

in vivo

ETP-45658 (22.7 mg/kg) decreases the level of phosphorylated Akt on serine 473 in the mammary ducts of transgenic mice[1].

IC 50

PI3Kα: 22.0 nM (IC50); PI3Kδ: 39.8 nM (IC50); PI3Kβ: 129.0 nM (IC50); PI3Kγ: 717.3 nM (IC50); DNA-PK: 70.6 nM (IC50); mTOR: 152.0 nM (IC50)

storage

Store at +4°C

3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol Suppliers

China 23 India 1 United Kingdom 1 United States 3 USA 1 Global 29
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
Email
klq@cw-bio.com
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China
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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sales@glpbio.cn
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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Hefei Mokai Pharmaceutical Technology Co., Ltd
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18130062233
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Hubei Kele Fine Chemical Co., Ltd
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027-59101668 19945030958
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Bide Pharmatech Ltd.
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400-1647117 13681763483
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product02@bidepharm.com
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Henan Alpha Chemical Co., Ltd.
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0371-55013243 15324716602
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2232176231@qq.com
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China
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Suzhou Zhixin Biotechnology Co., Ltd.
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0512-65118909 18100677375
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sales@szzxbio.com
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1198357-79-7, 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenolRelated Search:


  • 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
  • ETP 45658
  • 3-(1-Methyl-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol
  • Inhibitor,PI3K,breast,DNA-PK,Mammalian target of Rapamycin,DNA-dependent protein kinase,mTOR,inhibit,Phosphoinositide 3-kinase,ETP-45658,cancer
  • Phenol, 3-[1-methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-
  • ETP-45658, 10 mM in DMSO
  • 1198357-79-7