ChemicalBook > CAS DataBase List > N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
- Product Name
- N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
- CAS No.
- 339303-87-6
- Chemical Name
- N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
- Synonyms
- UCLA P130 2;GP130 receptor agonist-1;GP130 receptor agonist-1, 10 mM in DMSO;N-(4-Fluorophenyl)-4-phenyl-2-thiazolami;N-(4-Fluorophenyl)-4-phenylthiazol-2-amine;N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine;2-Thiazolamine, N-(4-fluorophenyl)-4-phenyl-;GP130 receptor agonist-1,neuroprotective,Inhibitor,penetrant,NMDA,inhibit,GP-130 receptor agonist-1,brain,Interleukin Related,GP130 receptor agonist1,GP130,GP130 receptor agonist 1
- CBNumber
- CB24902807
- Molecular Formula
- C15H11FN2S
- Formula Weight
- 270.32
- MOL File
- 339303-87-6.mol
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N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- A solid
- color
- White to off-white
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N-Bromosuccinimide Price
TRC
- Product number
- F632443
- Product name
- N-(4-Fluorophenyl)-4-phenyl-1,3-thiazol-2-amine
- Packaging
- 1mg
- Price
- $75
- Updated
- 2021/12/16
TRC
- Product number
- F632443
- Product name
- N-(4-Fluorophenyl)-4-phenyl-1,3-thiazol-2-amine
- Packaging
- 2.5mg
- Price
- $155
- Updated
- 2021/12/16
CSNpharm
- Product number
- CSN23176
- Product name
- UCLAGP1302
- Packaging
- 50mg
- Price
- $455
- Updated
- 2021/12/16
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N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Chemical Properties,Usage,Production
Uses
N-(4-Fluorophenyl)-4-phenyl-1,3-thiazol-2-amine is a gp130 agonist. Protects against NMDA-induced toxicity in primary hippocampal neurons in vitro. Increases STAT3 phosphorylation in SH-SY5Y cells. Brain penetrant.
in vivo
For GP130 receptor agonist-1 (Compound 2), mice are dosed orally at 10 or 30 mg/kg, or injected subcutaneously (SQ) at 10 mg/kg, and euthanized after 1, 2, 4, 6, and 8 h post dose. At 2 h after SQ delivery at 10 mg/kg the brain Cmax is 161 ng/g while dosing at 30 mg/kg orally, results in the brain Cmax of 156 ng/g (0.57 μM). The brain to plasma ratio for 2 is ～4:1 for oral 30 mg/kg and ～7.5:1 for 10 mg/kg SQ injection[1].
storage
Store at +4°C
N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Preparation Products And Raw materials
Raw materials
Preparation Products
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N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Suppliers
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