5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 14678-87-6
- Chemical Name
- 5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- AKOS BBS-00004494;BUTTPARK 19\09-71;SALOR-INT L251445-1EA;ETHYL 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE;5-amino-1-(4-chlorophenyl)pyrazole-4-carboxylic acid ethyl ester;5-amino-1-(4-chlorophenyl)-4-pyrazolecarboxylic acid ethyl ester;5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;1H-Pyrazole-4-carboxylic acid, 5-amino-1-(4-chlorophenyl)-, ethyl ester
- CBNumber
- CB2491473
- Molecular Formula
- C12H12ClN3O2
- Formula Weight
- 265.7
- MOL File
- 14678-87-6.mol
5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- L251445
- Product name
- ETHYL 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- L251445
- Product name
- ETHYL 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- B433868
- Product name
- Ethyl5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B175
- Product name
- Ethyl5-amino-1-(4-chlorophenyl)-pyrazole-4-carboxylate
- Packaging
- 1g
- Price
- $62
- Updated
- 2021/12/16
- Product number
- B175
- Product name
- Ethyl5-amino-1-(4-chlorophenyl)-pyrazole-4-carboxylate
- Packaging
- 5g
- Price
- $202
- Updated
- 2021/12/16
5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
68350-76-5
1073-69-4
14678-87-6
General procedure for the synthesis of ethyl 5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate from ethyl 2-cyano-3-methoxyacrylate and p-chlorophenylhydrazine: 5 g (28 mmol) of p-chlorophenylhydrazine, 3.86 g (28 mmol) of potassium carbonate, and 4.7 g (28 mmol) of ethyl 2-cyano-3-methoxyacrylate were sequentially added to a 100 mL round bottomed flask. The reaction mixture was stirred under reflux conditions for 24 hours. Upon completion of the reaction, 150 mL of ethyl acetate was added to the reaction mixture, followed by washing twice with 100 mL of water. The organic layer was separated, dried with anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure to afford 6.88 g (26 mmol) of ethyl 5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate of the target compound in 92% yield. The product was analyzed by mass spectrometry (EI) showing a molecular ion peak of 266 (M++1). The nuclear magnetic resonance hydrogen spectrum (1H-NMR, CDCl3) data were as follows: δ 7.78 (1H, s), 7.52-7.47 (4H, m), 5.28 (2H, brs), 4.31 (2H, q, J=8Hz), 1.37 (3H, t, J=8Hz).
References
[1] Patent: WO2005/40127, 2005, A1. Location in patent: Page/Page column 39
5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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