ChemicalBook > CAS DataBase List > 5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Product Name
5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
CAS No.
14678-87-6
Chemical Name
5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
Synonyms
AKOS BBS-00004494;BUTTPARK 19\09-71;SALOR-INT L251445-1EA;ETHYL 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE;5-amino-1-(4-chlorophenyl)pyrazole-4-carboxylic acid ethyl ester;5-amino-1-(4-chlorophenyl)-4-pyrazolecarboxylic acid ethyl ester;5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;1H-Pyrazole-4-carboxylic acid, 5-amino-1-(4-chlorophenyl)-, ethyl ester
CBNumber
CB2491473
Molecular Formula
C12H12ClN3O2
Formula Weight
265.7
MOL File
14678-87-6.mol
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5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L251445
Product name
ETHYL 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$30.7
Updated
2025/07/31
Sigma-Aldrich
Product number
L251445
Product name
ETHYL 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
Purity
AldrichCPR
Packaging
250MG
Price
$29.8
Updated
2024/03/01
TRC
Product number
B433868
Product name
Ethyl5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
B175
Product name
Ethyl5-amino-1-(4-chlorophenyl)-pyrazole-4-carboxylate
Packaging
1g
Price
$62
Updated
2021/12/16
AK Scientific
Product number
B175
Product name
Ethyl5-amino-1-(4-chlorophenyl)-pyrazole-4-carboxylate
Packaging
5g
Price
$202
Updated
2021/12/16
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5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

68350-76-5

1073-69-4

14678-87-6

General procedure for the synthesis of ethyl 5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate from ethyl 2-cyano-3-methoxyacrylate and p-chlorophenylhydrazine: 5 g (28 mmol) of p-chlorophenylhydrazine, 3.86 g (28 mmol) of potassium carbonate, and 4.7 g (28 mmol) of ethyl 2-cyano-3-methoxyacrylate were sequentially added to a 100 mL round bottomed flask. The reaction mixture was stirred under reflux conditions for 24 hours. Upon completion of the reaction, 150 mL of ethyl acetate was added to the reaction mixture, followed by washing twice with 100 mL of water. The organic layer was separated, dried with anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure to afford 6.88 g (26 mmol) of ethyl 5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate of the target compound in 92% yield. The product was analyzed by mass spectrometry (EI) showing a molecular ion peak of 266 (M++1). The nuclear magnetic resonance hydrogen spectrum (1H-NMR, CDCl3) data were as follows: δ 7.78 (1H, s), 7.52-7.47 (4H, m), 5.28 (2H, brs), 4.31 (2H, q, J=8Hz), 1.37 (3H, t, J=8Hz).

References

[1] Patent: WO2005/40127, 2005, A1. Location in patent: Page/Page column 39

5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Suppliers

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14678-87-6, 5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTERRelated Search:

5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ethyl 5-amino-1-(4-chlorophenyl)-3-cyclobutyl-1H-pyrazole-4-carboxylate 5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER ethyl 5-amino-1-(2,4-dichlorophenyl)pyrazole-4-carboxylate ETHYL 5-AMINO-1-(3,4-DICHLOROPHENYL)-PYRAZOLE-4-CARBOXYLATE ETHYL 5-AMINO-1-(4-CHLOROPHENYL)-3-(2-HYDROXYETHOXY)-1H-PYRAZOLE-4-CARBOXYLATE 5-AMINO-1-[(2-ETHOXY-4-CHLORO-6-FLUORO)PHENYL]-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER ethyl 5-amino-1-(4-chlorophenyl)-3-cyclopentyl-1H-pyrazole-4-carboxylate

  • ETHYL 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
  • BUTTPARK 19\09-71
  • AKOS BBS-00004494
  • 5-AMINO-1-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
  • 5-amino-1-(4-chlorophenyl)-4-pyrazolecarboxylic acid ethyl ester
  • 5-amino-1-(4-chlorophenyl)pyrazole-4-carboxylic acid ethyl ester
  • SALOR-INT L251445-1EA
  • 1H-Pyrazole-4-carboxylic acid, 5-amino-1-(4-chlorophenyl)-, ethyl ester
  • 14678-87-6