ChemicalBook > CAS DataBase List > 2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&

2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&

Product Name
2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&
CAS No.
26907-54-0
Chemical Name
2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&
Synonyms
2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&;1,3,4-Thiadiazol-2-aMine, 5-(4-Methylphenyl)-;2-Amino-5-(4-methylphenyl)-1,3,4-thiadiazole 97%;JRH-02705, 5-p-Tolyl-1,3,4-thiadiazol-2-amine, 97%;5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE);2-Amino-5-(p-tolyl)-1,3,4-thiadiazole, 5-(p-Tolyl)-1,3,4-thiadiazol-2-amine;5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine, 5-(p-Tolyl)-1,3,4-thiadiazol-2-amine;4-(5-Amino-1,3,4-thiadiazol-2-yl)toluene, 5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine
CBNumber
CB2500357
Molecular Formula
C9H9N3S
Formula Weight
191.25
MOL File
26907-54-0.mol
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2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI& Property

Melting point:
218-222 °C
Boiling point:
364.9±35.0 °C(Predicted)
Density 
1.281±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
3.11±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
663565
Product name
2-Amino-5-(4-methylphenyl)-1,3,4-thiadiazole
Purity
97%
Packaging
5g
Price
$223
Updated
2022/05/15
TRC
Product number
T733833
Product name
5-(p-Tolyl)-1,3,4-thiadiazol-2-amine
Packaging
50mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA54318
Product name
2-Amino-5-(4-methylphenyl)-1,3,4-thiadiazole
Packaging
1g
Price
$83
Updated
2021/12/16
AK Scientific
Product number
5728AH
Product name
5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine
Packaging
1g
Price
$105
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA54318
Product name
2-Amino-5-(4-methylphenyl)-1,3,4-thiadiazole
Packaging
2g
Price
$150
Updated
2021/12/16
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2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI& Chemical Properties,Usage,Production

Synthesis

79-19-6

99-94-5

26907-54-0

General procedure for the synthesis of 5-p-tolylphenyl-2-amino-1,3,4-thiadiazole from aminothiourea and p-toluic acid: 5.1.1 Synthesis of 5-(4-morpholinophenyl)-1,3,4-thiadiazol-2-amine (59) 4-Morpholino benzoic acid (5.18 g, 25 mmol) and N-amino thiourea (2.28 g, 25 mmol) were dissolved in POCl3 (7 mL) and stirred vigorously at 75°C for 0.5 hr. After the reaction was completed, H2O (30 mL) was added and the reaction mixture was heated to reflux for 4 hours. Subsequently, the reaction solution was adjusted with 50% NaOH solution to pH 8. The mixture was filtered and the resulting filter cake was recrystallized with ethanol to give 3.90 g of yellow crystalline compound 59 in 59% yield. Compounds 60-81 were synthesized in the same way. 5.1.1.4 Synthesis of 5-(p-tolyl)-1,3,4-thiadiazol-2-amine (63) Yield: 98%, Melting point: 194-195 °C (EtOH). eSI-MS m/z: 192.3 [M + H]+; 1H NMR (DMSO-d6) δ 2.34 (s, 3H), 7.27 (d, J = 8.4 Hz, 2H), 7.35 (s, 2H), 7.64 (d, J = 8.4 Hz, 2H).

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5766 - 5775
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 14, p. 6663 - 6668
[3] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 49 - 63
[4] European Journal of Medicinal Chemistry, 2015, vol. 106, p. 75 - 84
[5] Medicinal Chemistry Research, 2012, vol. 21, # 6, p. 816 - 824

2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI& Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI& Suppliers

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26907-54-0, 2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&Related Search:

4-(5-AMINO-1,3,4-THIADIAZOL-2-YL)BENZOIC ACID 2-AMINO-5-(4-AMYLPHENYL)-1,3,4-THIADIAZOLE 5-(4-ethylphenyl)-1,3,4-thiadiazol-2-amine 5-(2,4-dimethylphenyl)-1,3,4-thiadiazol-2-amine 5-BIPHENYL-4-YL-[1,3,4]THIADIAZOL-2-YLAMINE 5-(4-methyl-3-nitrophenyl)-1,3,4-thiadiazol-2-amine 2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI& 2-AMINO-5-(4-TERT-BUTYLPHENYL)-1,3,4-THIADIAZOLE 5-(3-methoxy-4-methylphenyl)-1,3,4-thiadiazol-2-amine 4-(5-AMINO-[1,3,4]THIADIAZOL-2-YL)-BENZONITRILE 5-(2,3-dihydro-1H-inden-5-yl)-1,3,4-thiadiazol-2-amine 5-(4-ISOPROPYLPHENYL)-1,3,4-THIADIAZOL-2-AMINE 5-(5-amino-1,3,4-thiadiazol-2-yl)-2-methylphenol 5-(4-TRIFLUOROMETHYL-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE 5-(2,4,6-trimethylphenyl)-1,3,4-thiadiazol-2-amine 5-(3-fluoro-4-methylphenyl)-1,3,4-thiadiazol-2-amine 5-(4-METHYL-3,5-DINITRO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE 5-(3,4-DIMETHYL-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE

  • JRH-02705, 5-p-Tolyl-1,3,4-thiadiazol-2-amine, 97%
  • 4-(5-Amino-1,3,4-thiadiazol-2-yl)toluene, 5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine
  • 2-Amino-5-(4-methylphenyl)-1,3,4-thiadiazole 97%
  • 2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&
  • 5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine, 5-(p-Tolyl)-1,3,4-thiadiazol-2-amine
  • 2-Amino-5-(p-tolyl)-1,3,4-thiadiazole, 5-(p-Tolyl)-1,3,4-thiadiazol-2-amine
  • 5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE)
  • 1,3,4-Thiadiazol-2-aMine, 5-(4-Methylphenyl)-
  • 26907-54-0