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3-(METHYLSULFONYL)ANILINE

Product Name
3-(METHYLSULFONYL)ANILINE
CAS No.
35216-39-8
Chemical Name
3-(METHYLSULFONYL)ANILINE
Synonyms
m-(Methylsulfonyl)aniline;3-(Methylsulphonyl)aniline;3-Methylsulfonylphenylamine;P-Toluene Suphonamide (PTSA);3-Aminophenyl methyl sulfone;3-(methylsulfonyl)Benzenamine;3-Aminophenyl methyl sulphone;Benzenamine, 3-(methylsulfonyl)-
CBNumber
CB2500645
Molecular Formula
C7H9NO2S
Formula Weight
171.22
MOL File
35216-39-8.mol
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3-(METHYLSULFONYL)ANILINE Property

Melting point:
72 °C
Boiling point:
165-170 °C(Press: 0.3 Torr)
Density 
1.282±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
2.66±0.10(Predicted)
color 
Light red
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Safety

HS Code 
2921420090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M218785
Product name
3-(Methanesulfonyl)aniline
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
M218785
Product name
3-(Methanesulfonyl)aniline
Packaging
100mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
8663-1-Z6
Product name
3-(Methylsulfonyl)aniline
Packaging
1g
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
127742
Product name
3-(Methylsulphonyl)aniline
Purity
>95%
Packaging
500mg
Price
$134
Updated
2021/12/16
SynQuest Laboratories
Product number
8663-1-Z6
Product name
3-(Methylsulfonyl)aniline
Packaging
5G
Price
$176
Updated
2021/12/16
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3-(METHYLSULFONYL)ANILINE Chemical Properties,Usage,Production

Uses

3-(Methylsulfonyl)aniline is used in the preparation of substituted pyrazolopyrimidines as IRAK4 kinase inhibitors.

Synthesis

1783-81-9

35216-39-8

General procedure for the synthesis of 3-methylsulfonylaniline from 3-aminothioanisole: A mixture of Na2WO4 (0.067 g), 1 drop of acetic acid and H2O (5 mL) was added to a flask and heated to 65 °C. Subsequently, 3-methylthioaniline (500 mg, 3.59 mmol) was added and H2O2 (1.1 mL, 10.77 mmol) was added slowly and dropwise. The reaction mixture was stirred at 65 °C for 1.5 hours. After completion of the reaction, it was cooled to room temperature and extracted by adding 1N HCl (80 mL) and DCM (50 mL). The organic and aqueous phases were separated and the aqueous phase was then washed with DCM. The aqueous phase was alkalized with 25% NaOH solution and extracted with DCM. The organic phases were combined, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure to give the 3-methylsulfonylaniline derivative.Preparation of 3-(methylsulfonyl)aniline (158): Compound 158 was prepared from 3-methylsulfonylaniline (153) according to Method E. 557 mg of brown powder was obtained in 92% yield.1H NMR (500 MHz, CDCl3) δ 3.03 (s, 3H), 6.89 (ddd, J = 0.8, 2.3, 8.0 Hz, 1H), 7.21 (t, J = 2.1 Hz, 1H), 7.24 (dt, J = 1.1, 7.7 Hz, 1H), 7.30 (t, J = 7.8 Hz, 1H). 13C NMR (126 MHz, CDCl3) δ 44.40, 112.69, 116.37, 119.72, 130.30, 141.16, 141.16. 130.30, 141.16, 147.69. LC-MS (M+H+) calculated value C7H9NO2S 172, measured value 172.

References

[1] Patent: WO2014/100833, 2014, A1. Location in patent: Paragraph 0080; 0232
[2] Patent: WO2007/60026, 2007, A1. Location in patent: Page/Page column 49-50
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 18, p. 4741 - 4745

3-(METHYLSULFONYL)ANILINE Preparation Products And Raw materials

Raw materials

Hexane Ethanol Potassium hydroxide Sodium chloride Ammonium chloride Ethyl acetate Sodium bicarbonate Nitric acid Iron Methyl phenyl sulfone

Preparation Products

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View Lastest Price from 3-(METHYLSULFONYL)ANILINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-(METHYLSULFONYL)ANILINE 35216-39-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-16
Career Henan Chemical Co
Product
3-(METHYLSULFONYL)ANILINE 35216-39-8
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg； 25kg
Release date
2020-01-09

35216-39-8, 3-(METHYLSULFONYL)ANILINERelated Search:

1-Chloro-4-(ethylsulfonyl)-2-nitrobenzene 3,3'-Sulfonyldianiline 2-[(3-Aminophenyl) Sulfonyl)Ethanol 3,3'-Diamino-4,4'-dihydroxydiphenyl sulfone bis(4-chloro-3-nitrophenyl) sulphone 4-METHYLSULFONYL-2-NITROFLUOROBENZENE 2-METHANESULFONYL-4-NITROPHENYLAMINE 3,6-THIOXANTHENEDIAMINE-10,10-DIOXIDE O-TOLIDINE SULFONE 4-Chloro-3-nitrophenyl methyl sulfone 2-Nitro-4-methylsulfonyltoluene REACTIVE BLACK 5 3-Nitrophenyl sulphone BIS(4-FLUORO-3-NITROPHENYL) SULFONE 3,3'-DIAZIDODIPHENYL SULFONE 2-AMINO-4-(ETHYLSULFONYL)PHENOL UNIBLUE A SODIUM SALT LUCIFER YELLOW VS DILITHIUM SALT

  • 3-Aminophenyl methyl sulphone
  • 3-(methylsulfonyl)Benzenamine
  • m-(Methylsulfonyl)aniline
  • 3-Aminophenyl methyl sulfone
  • 3-Methylsulfonylphenylamine
  • P-Toluene Suphonamide (PTSA)
  • 3-(Methylsulphonyl)aniline
  • Benzenamine, 3-(methylsulfonyl)-
  • 35216-39-8