ACETOPHENAZINE MALEATE (200 MG) Property

Melting point:

167-168.5°

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

Yellow to Orange

Stability:

Hygroscopic

Safety

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

RTECS 

OB4180000

Toxicity

LD50 orally in rats: 433 mg/kg (Schafer)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

ACETOPHENAZINE MALEATE (200 MG) Chemical Properties,Usage,Production

Originator

Tindal ,Schering ,US ,1961

Uses

Antipsychotic.

Definition

ChEBI: A maleate salt obtained by combining acetophenazine with two molar equivalents of maleic acid.

Manufacturing Process

The requisite intermediate, 10-(3-chloropropyl)-2-acetylphenothiazineis prepared as follows: To a suspension of sodium amide (from 3 grams of sodium) in 300 ml of liquid ammonia is added 30 grams of 2- acetylphenothiazine. After stirring for one hour, there is added 19 grams of 1- bromo-3-chloropropane. The ammonia is allowed to evaporate and the residue is diluted with 200 ml of water. The mixture is extracted with ether and the ether solution is dried over anhydrous sodium sulfate, filtered and concentrated.
The residue consists of crude 10-(3-chloropropy1)-2-acetylphenothiazine as a viscous oil and is used in the next step without further purification. The crude base obtained from the reaction of 10-(3-chloropropyl)-2-acetylphenothiazine with 1-(2-hydroxyethyl)piperazine is purified by conversion to its dimaleate salt, MP 167-168.5°C from ethanol.

brand name

Tindal (Schering).

Therapeutic Function

Tranquilizer

Safety Profile

Poison by ingestion, intraperitoneal,and intravenous routes. Severe eye irritant.