ChemicalBook > CAS DataBase List > Prochlorperazine

Prochlorperazine

Product Name
Prochlorperazine
CAS No.
58-38-8
Chemical Name
Prochlorperazine
Synonyms
Compazine;PERPHENAZINE BASE;6140rp;rp6140;6140 RP;Emelent;Nipodal;RP-6140;skf4657;Temetid
CBNumber
CB7352500
Molecular Formula
C20H24ClN3S
Formula Weight
373.94
MOL File
58-38-8.mol
More
Less

Prochlorperazine Property

Melting point:
228 °C
Boiling point:
260-275 °C(Press: 2 Torr)
Density 
1.1679 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
pKa 8.1(H2O,t =24±1,I undefined) (Uncertain)
form 
Solid
color 
White to Yellow
Water Solubility 
14.96mg/L(24 ºC)
BCS Class
2
CAS DataBase Reference
58-38-8(CAS DataBase Reference)
NIST Chemistry Reference
Prochlorperazine(58-38-8)
More
Less

Safety

Hazardous Substances Data
58-38-8(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 1800mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
P755790
Product name
Prochlorperazine
Packaging
10mg
Price
$100
Updated
2021/12/16
Usbiological
Product number
462997
Product name
Prochlorperazine
Packaging
10mg
Price
$368
Updated
2021/12/16
ApexBio Technology
Product number
A8508
Product name
Prochlorperazine
Packaging
100mg
Price
$21
Updated
2021/12/16
ApexBio Technology
Product number
A8508
Product name
Prochlorperazine
Packaging
5g
Price
$45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003935
Product name
PROCHLORPERAZINE
Purity
95.00%
Packaging
5MG
Price
$442.5
Updated
2021/12/16
More
Less

Prochlorperazine Chemical Properties,Usage,Production

Uses

antiemetic, antipsychotic, treatment of vertigo

Uses

Prochlorperazine is antiemetic, antipsychotic; used in treatment of vertigo.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.

brand name

Compazine (GlaxoSmithKline).

Clinical Use


Nausea and vomiting
Labyrinthine disorders
Psychoses
Severe anxiety

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl-.

Veterinary Drugs and Treatments

Prochlorperazine as a single agent is used in dogs and cats as an antiemetic. The only approved products for animals are combination products containing prochlorperazine, isopropamide, with or without neomycin (Darbazine?, Neo-Darbazine?—SKB Labs) which are no longer marketed in the USA. The approved indications for these products include: vomiting, non-specific gastroenteritis, drug induced diarrhea, infectious diarrhea, spastic colitis, and motion sickness in dogs and cats (injectable product only).

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone.
Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide, dronedarone and amiodarone - avoid with amiodarone and dronedarone.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
Antidepressants: increase concentrations and additive antimuscarinic effects, notably with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
Antiepileptics: antagonised (convulsive threshold lowered).
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
Desferrioxamine: avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.

Metabolism

Prochlorperazine undergoes extensive first pass metabolism in the gut wall. It is also extensively metabolised in the liver and is excreted in the urine and bile. The metabolites are inactive.

Prochlorperazine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Prochlorperazine Suppliers

Shanghai Pharmaceutical Co., Ltd. Zhaohui
Tel
86-021-66866686
Fax
86-021-56869953
Country
China
ProdList
6
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shenzhen Sendi Biological Technology Co., Ltd.
Tel
18124570582 TEL:0755-23574479 2355327139
Fax
0755-23229476 QQ: 2355327139
Email
siliao02@yccreate.com
Country
China
ProdList
6116
Advantage
58
Zhuhai JiaYi Biological Technology Co., Ltd.
Tel
18578209868 2355327026
Fax
18578209868 QQ:2355327026
Email
steroidbest@hotmail.com
Country
China
ProdList
6501
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
More
Less

View Lastest Price from Prochlorperazine manufacturers

Career Henan Chemica Co
Product
Prochlorperazine 58-38-8
Price
US $1.80/KG
Min. Order
1g
Purity
96%-99%
Supply Ability
1kg/10kg/100kg
Release date
2020-11-07
Xiamen Wonderful Bio Technology Co., Ltd.
Product
prochlorperazine 58-38-8
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
6000
Release date
2023-06-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
Prochlorperazine 58-38-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

58-38-8, ProchlorperazineRelated Search:


  • 10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-
  • 2-Chloro-10-(3-(1-methyl-4-piperazinyl)-propyl)-phenothiazine
  • 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazin
  • 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-phenothiazin
  • 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine
  • 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine
  • 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine
  • 3-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine
  • 6140 R.P.
  • 6140 RP
  • 6140rp
  • Bayer A 173
  • bayera173
  • Capazine
  • Chlormeprazine
  • Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine
  • chloro-3(n-methylpiperazinyl-3propyl)-10phenothiazine
  • chloro-3(n-methylpiperazinyl-3propyl)-10phenothiazine(french)
  • Chlorperazine
  • Compazine
  • Emelent
  • Eskatrol
  • Kronocin
  • Meterazin
  • Meterazine
  • n-(gamma-(4’-methylpiperazinyl-1’)propyl)-3-chlorophenothiazine
  • N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine
  • n-[gamma-(4’-methylpiperazinyl-1’)propyl]-3-chlorophenothiazine
  • Nipodal
  • Phenothiazine, 2-chloro-10-[3-(1-methyl-4-piperazinyl)propyl]-
  • Chloromeprazine
  • 3-Chloro-10-chlorperazine
  • 10-[3-(4-Methylpiperazino)propyl]-2-chloro-10H-phenothiazine
  • Prochlorperazine Base
  • PERPHENAZINE BASE
  • Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-
  • Prochloroperazine
  • Prochlorpemazine
  • Prochlorperazin
  • prochlorpermazine
  • Prochlorpromazine
  • Procloperazine
  • Proclorperazine
  • rp6140
  • RP-6140
  • SKF 4657
  • skf4657
  • Stemetil
  • Tementil
  • Temetid
  • PROCHLORPERAZINE
  • 2-chloro-10-(3-(4-methylpiperazin-1-yl)propyl)phenothiazine
  • Bayer A 17
  • 10H-PHENOTHIAZINE, 2-CHLORO-10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-, (Z)-2-BUTENEDIOATE
  • Prochlorperazine USP/EP/BP
  • Prochlorperazine EP
  • Praziquantel Impurity 7-d11
  • Propachloropiperazine monomer