PROCHLORPERAZINE MALEATE
- Product Name
- PROCHLORPERAZINE MALEATE
- CAS No.
- 84-02-6
- Chemical Name
- PROCHLORPERAZINE MALEATE
- Synonyms
- PROCHLORPERAZINE DIMALEATE;emetiral;Vertigon;buccastem;pasotomin;nibromina;enedioate(1:2);meterazinmaleate;Einecs 201-511-3;stemetildimaleate
- CBNumber
- CB2439552
- Molecular Formula
- C28H32ClN3O8S
- Formula Weight
- 606.09
- MOL File
- 84-02-6.mol
PROCHLORPERAZINE MALEATE Property
- Melting point:
- 1750C
- storage temp.
- 2-8°C
- solubility
- Very slightly soluble in water and in ethanol (96 per cent).
- pka
- pKa 8.1(H2O,t =24±1) (Uncertain)
- color
- White
- λmax
- 313nm(MeOH)(lit.)
- Merck
- 14,7761
- Stability:
- Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H336May cause drowsiness or dizziness
H362May cause harm to breast-fed children
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- P9178
- Product name
- Prochlorperazine dimaleate salt
- Packaging
- 5g
- Price
- $68.2
- Updated
- 2024/03/01
- Product number
- P3200000
- Product name
- Prochlorperazine maleate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- P3200000
- Price
- $218
- Updated
- 2023/06/20
- Product number
- BP638
- Product name
- Prochlorperazine maleate
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $221
- Updated
- 2023/06/20
- Product number
- PHR3114
- Product name
- Prochlorperazine Maleate
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 500MG
- Price
- $175
- Updated
- 2022/05/15
- Product number
- 1566001
- Product name
- Prochlorperazine maleate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200MG
- Price
- $400
- Updated
- 2022/05/15
PROCHLORPERAZINE MALEATE Chemical Properties,Usage,Production
Description
Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 μM for CME.1?Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2?A clinically useful antipsychotic agent3?with antimigraine4?and antiemetic activity5.
Chemical Properties
Off-White Powder
Uses
Antiemetic;Dopamine antagonist
Uses
Antiemetic.
brand name
Compazine (GlaxoSmithKline).
General Description
Prochlorperazinemaleate, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazinemaleate (Compazine), is in the piperazine subgroupof the phenothiazines, characterized by high-milligramantipsychotic potency, a high prevalence of EPS, and lowsedative and autonomic effects. Prochlorperazine is more potenton a milligram basis than its alkylamino counterpart,chlorpromazine. Because of the high prevalence of EPS, however,it is used mainly for its antiemetic effect, not for its antipsychoticeffect.
Biological Activity
D 2 receptor antagonist. Also interacts with 5-HT 3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo .
Biochem/physiol Actions
Phenothiazine antipsychotic; D2 dopamine receptor antagonist; antispasmodic
References
References/Citations 1) Daniel?et al.?(2015),?Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic,?16?635 2) Chew?et al.?(2020),?Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell,?180?895 3) Hollister?et al.?(1969),?Clinical use of psychotherapeutic drugs: current status;?Clin. Pharmacol. Ther.,?10?170 4) Cook and Newberry (2018),?Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J.,?40?148 5) Van den Berg?et al.?(1996),?The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care,?24?538
PROCHLORPERAZINE MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PROCHLORPERAZINE MALEATE manufacturers
- Product
- PROCHLORPERAZINE MALEATE 84-02-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-23