PROCHLORPERAZINE MALEATE

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PROCHLORPERAZINE MALEATE

Product Name: PROCHLORPERAZINE MALEATE
CAS No.: 84-02-6
Chemical Name: PROCHLORPERAZINE MALEATE
Synonyms: PROCHLORPERAZINE DIMALEATE;emetiral;Vertigon;buccastem;pasotomin;nibromina;enedioate(1:2);meterazinmaleate;Einecs 201-511-3;stemetildimaleate
CBNumber: CB2439552
Molecular Formula: C28H32ClN3O8S
Formula Weight: 606.09
MOL File: 84-02-6.mol

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PROCHLORPERAZINE MALEATE Property

Melting point:: 1750C
storage temp.: 2-8°C
solubility: Very slightly soluble in water and in ethanol (96 per cent).
pka: pKa 8.1(H2O,t =24±1) (Uncertain)
color: White
λmax: 313nm(MeOH)(lit.)
Merck: 14,7761
Stability:: Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3
RTECS: SO3150000
HS Code: 2934302300
Toxicity: LD50 in mice (mg/kg): 400 s.c.; 120 i.p.; 90 i.v., 400 orally (Courvoisier)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

H362May cause harm to breast-fed children

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P9178
Product name: Prochlorperazine dimaleate salt
Packaging: 5g
Price: $68.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: P3200000
Product name: Prochlorperazine maleate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: P3200000
Price: $218
Updated: 2023/06/20

Sigma-Aldrich

Product number: BP638
Product name: Prochlorperazine maleate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $221
Updated: 2023/06/20

Sigma-Aldrich

Product number: PHR3114
Product name: Prochlorperazine Maleate
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $175
Updated: 2022/05/15

Sigma-Aldrich

Product number: 1566001
Product name: Prochlorperazine maleate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200MG
Price: $400
Updated: 2022/05/15

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PROCHLORPERAZINE MALEATE Chemical Properties,Usage,Production

Description

Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 μM for CME.1?Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2?A clinically useful antipsychotic agent3?with antimigraine4?and antiemetic activity5.

Chemical Properties

Off-White Powder

Uses

Antiemetic;Dopamine antagonist

Uses

Antiemetic.

brand name

Compazine (GlaxoSmithKline).

General Description

Prochlorperazinemaleate, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazinemaleate (Compazine), is in the piperazine subgroupof the phenothiazines, characterized by high-milligramantipsychotic potency, a high prevalence of EPS, and lowsedative and autonomic effects. Prochlorperazine is more potenton a milligram basis than its alkylamino counterpart,chlorpromazine. Because of the high prevalence of EPS, however,it is used mainly for its antiemetic effect, not for its antipsychoticeffect.

Biological Activity

D 2 receptor antagonist. Also interacts with 5-HT 3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo .

Biochem/physiol Actions

Phenothiazine antipsychotic; D2 dopamine receptor antagonist; antispasmodic

References

References/Citations 1) Daniel?et al.?(2015),?Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic,?16?635 2) Chew?et al.?(2020),?Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell,?180?895 3) Hollister?et al.?(1969),?Clinical use of psychotherapeutic drugs: current status;?Clin. Pharmacol. Ther.,?10?170 4) Cook and Newberry (2018),?Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J.,?40?148 5) Van den Berg?et al.?(1996),?The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care,?24?538

PROCHLORPERAZINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PROCHLORPERAZINE MALEATE Suppliers

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View Lastest Price from PROCHLORPERAZINE MALEATE manufacturers

Dideu Industries Group Limited

Product: PROCHLORPERAZINE MALEATE 84-02-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-23

84-02-6, PROCHLORPERAZINE MALEATERelated Search:

10-METHYLPHENOTHIAZINE 5-CHLORO-2-(METHYLTHIO)ANILINE 2-AMINO-4'-CHLORODIPHENYL SULFIDE Promazine hydrochloride 3-CHLORODIPHENYLAMINE Promazine 10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine 1-(3-AMINOPROPYL)PIPERAZINE Chlorpromazine 1-(3-AMINOPROPYL)-4-METHYLPIPERAZINE 2-Chlorophenothiazine PROCHLORPERAZINE MALEATE 1-[3-(DIMETHYLAMINO)PROPYL]PIPERAZINE PIPERAZINE HEXAHYDRATE chlorproethazine Ammonium hydrogen maleate Prochlorperazine 2-Amino-4-chlorodiphenylsulfide

2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-phenothiazinmaleate(1:2)

buccastem

emetiral

enedioate(1:2)

meterazinmaleate

nibromina

pasotomin

prochloroproazinehydrogenmaleate

prochlorperazinebimaleate

prochlorperazinehydrogenmaleate

prochlorperazinudimaleat

stemetildimaleate

Prochloroperazine Dimaleate

Prochlorperazine Dimaleate Also See: P755800

Vertigon

Prochlorpromazine dimaleate

10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioate (1:2)

Einecs 201-511-3

2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazinedimaleate

Prochlorperazine Maleate (200 mg)

10H-Phenothiazine, 2-chloro-10-3-(4-methyl-1-piperazinyl)propyl-, (2Z)-2-butenedioate (1:2)

PROCHLORPERAZINEMALEATE,USP

2-chloro-10-(3-(4-Methylpiperazin-1-yl)propyl)-10H-phenothiazine

PROCHLORPERAZINE DIMALEATE

PROCHLORPERAZINE DIMALEATE SALT

PROCHLORPERAZINE MALEATE

2-chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine,dimaleate

2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazin(z)-2-but

2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazinedimaleate

Prochlorperazine Maleate RS

Prochlorperazine maleate CRS

2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine Dimaleate

PROCHLORPERAZINE MALEATE USP/EP/BP

Prochlorperazine dimaleate saltQ: What is Prochlorperazine dimaleate salt Q: What is the CAS Number of Prochlorperazine dimaleate salt Q: What is the storage condition of Prochlorperazine dimaleate salt Q: What are the applications of Prochlorperazine dimaleate salt

Prochlorperazine Maleate (1566001)

PROCHLORPERAZINE HCL IP/BP/USP

Prochlorperazine dimaleate in methanol

C16291000 ProchlorperazinEmaleate

84-02-6

1984-2-6

C20H24ClN3SC4H4O42

C28H32ClN3O8S

C24H24ClN3S2C4H4O4

C20H24ClN3S2C4H4O4

Heterocyclic Compounds

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Antagonists

Dopaminergics

Neurotransmitters