Promazine
- Product Name
- Promazine
- CAS No.
- 58-40-2
- Chemical Name
- Promazine
- Synonyms
- A-145;Wy-1094;RP-3276;Esparin;Promazine;NSC 31447;Sinophenin;Chlorpromazine-003;Promazine USP/EP/BP;Promazine Dimer Impurity
- CBNumber
- CB5875452
- Molecular Formula
- C17H20N2S
- Formula Weight
- 284.4191
- MOL File
- 58-40-2.mol
Promazine Property
- Melting point:
- 25°C
- Boiling point:
- bp0.3 203-210°
- Density
- 1.1256 (rough estimate)
- refractive index
- 1.6000 (estimate)
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- pKa 9.4(H2O,t =24±1) (Uncertain)
- form
- Solid
- color
- Off-White to Pale Beige
- Water Solubility
- 14.22mg/L(24 ºC)
- Stability:
- Hygroscopic
- NIST Chemistry Reference
- Promazine(58-40-2)
Safety
- Hazardous Substances Data
- 58-40-2(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: 350mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- API0007567
- Product name
- N,N-DIMETHYL-3-PHENOTHIAZIN-10-YL-PROPAN-1-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.88
- Updated
- 2021/12/16
Promazine Chemical Properties,Usage,Production
Uses
ntipsychotic.
Uses
In psychiatric practice, promazine is used in minor cases of psychomotor excitement in schizophrenics, in paranoid and manic-depressive conditions, for neurosis, alcoholic psychosis, and others. It is sometimes used in anesthesiological practice.
Uses
Promazine is an antipsychotic and a tranquilizer.
Definition
ChEBI: A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.
brand name
Sparine (Baxter Healthcare); Sparine (Wyeth).
General Description
Promazine, 10-[3-(dimethylamino) propyl-(phenothiazine monohydrochloride (Sparine), was introducedinto antipsychotic therapy after its 2-chloro-substitutedrelative. The 2H-substituent vis-à-vis the 2Clsubstituent gives a milligram potency decrease as an antipsychotic,as encompassed in Gordon’s rule. Tendency toEPS is also lessened, which may be significant, especially ifit is decreased less than antipsychotic potency.
Synthesis
Promazine, 10-(3-dimethylaminopropyl)phenothiazine (6.1.1), is prepared by the alkylation of phenothiazine with 3-dimethylaminopropylchloride in the presence of sodium amide [1¨C3].
Promazine Preparation Products And Raw materials
Raw materials
Preparation Products
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