ChemicalBook > CAS DataBase List > Promazine

Promazine

Product Name
Promazine
CAS No.
58-40-2
Chemical Name
Promazine
Synonyms
A-145;Wy-1094;RP-3276;Esparin;Promazine;NSC 31447;Sinophenin;Chlorpromazine-003;Promazine USP/EP/BP;Promazine Dimer Impurity
CBNumber
CB5875452
Molecular Formula
C17H20N2S
Formula Weight
284.4191
MOL File
58-40-2.mol
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Promazine Property

Melting point:
25°C
Boiling point:
bp0.3 203-210°
Density 
1.1256 (rough estimate)
refractive index 
1.6000 (estimate)
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
pKa 9.4(H2O,t =24±1) (Uncertain)
form 
Solid
color 
Off-White to Pale Beige
Water Solubility 
14.22mg/L(24 ºC)
Stability:
Hygroscopic
NIST Chemistry Reference
Promazine(58-40-2)
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Safety

Hazardous Substances Data
58-40-2(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 350mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0007567
Product name
N,N-DIMETHYL-3-PHENOTHIAZIN-10-YL-PROPAN-1-AMINE
Purity
95.00%
Packaging
5MG
Price
$501.88
Updated
2021/12/16
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Promazine Chemical Properties,Usage,Production

Uses

ntipsychotic.

Uses

In psychiatric practice, promazine is used in minor cases of psychomotor excitement in schizophrenics, in paranoid and manic-depressive conditions, for neurosis, alcoholic psychosis, and others. It is sometimes used in anesthesiological practice.

Uses

Promazine is an antipsychotic and a tranquilizer.

Definition

ChEBI: A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.

brand name

Sparine (Baxter Healthcare); Sparine (Wyeth).

General Description

Promazine, 10-[3-(dimethylamino) propyl-(phenothiazine monohydrochloride (Sparine), was introducedinto antipsychotic therapy after its 2-chloro-substitutedrelative. The 2H-substituent vis-à-vis the 2Clsubstituent gives a milligram potency decrease as an antipsychotic,as encompassed in Gordon’s rule. Tendency toEPS is also lessened, which may be significant, especially ifit is decreased less than antipsychotic potency.

Synthesis

Promazine, 10-(3-dimethylaminopropyl)phenothiazine (6.1.1), is prepared by the alkylation of phenothiazine with 3-dimethylaminopropylchloride in the presence of sodium amide [1¨C3].

Promazine Preparation Products And Raw materials

Raw materials

Preparation Products

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Promazine Suppliers

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View Lastest Price from Promazine manufacturers

Dideu Industries Group Limited
Product
Promazine 58-40-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-23

58-40-2, PromazineRelated Search:


  • PHENOTHIAZINE,10-(3-(DIMETHYLAMINO)PROPYL)-
  • N,N-Dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
  • dimethyl(3-phenothiazin-10-ylpropyl)amine
  • Chlorpromazine Impurity 4
  • A-145
  • RP-3276
  • Wy-1094
  • Promazine
  • N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine
  • N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine
  • Chlorpromazine impurity 1
  • Chlorpromazine Impurity 3(Chlorpromazine EP Impurity C)
  • Chlorpromazine-003
  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-
  • Promazine USP/EP/BP
  • Chlorpromazine hydrochloride EP Impurity C
  • Esparin
  • NSC 31447
  • Sinophenin
  • Promazine Dimer Impurity
  • 58-40-2