Promazine

Product Name: Promazine
CAS No.: 58-40-2
Chemical Name: Promazine
Synonyms: A-145;Wy-1094;RP-3276;Esparin;Promazine;NSC 31447;Sinophenin;Chlorpromazine-003;Promazine USP/EP/BP;Promazine Dimer Impurity
CBNumber: CB5875452
Molecular Formula: C17H20N2S
Formula Weight: 284.4191
MOL File: 58-40-2.mol

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Promazine Property

Melting point:: 25°C
Boiling point:: bp0.3 203-210°
Density: 1.1256 (rough estimate)
refractive index: 1.6000 (estimate)
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: pKa 9.4(H2O,t =24±1) (Uncertain)
form: Solid
color: Off-White to Pale Beige
Water Solubility: 14.22mg/L(24 ºC)
Stability:: Hygroscopic
NIST Chemistry Reference: Promazine(58-40-2)

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Safety

Hazardous Substances Data: 58-40-2(Hazardous Substances Data)
Toxicity: LD50 oral in rat: 350mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0007567
Product name: N,N-DIMETHYL-3-PHENOTHIAZIN-10-YL-PROPAN-1-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $501.88
Updated: 2021/12/16

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Promazine Chemical Properties,Usage,Production

Uses

ntipsychotic.

Uses

In psychiatric practice, promazine is used in minor cases of psychomotor excitement in schizophrenics, in paranoid and manic-depressive conditions, for neurosis, alcoholic psychosis, and others. It is sometimes used in anesthesiological practice.

Uses

Promazine is an antipsychotic and a tranquilizer.

Definition

ChEBI: A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.

brand name

Sparine (Baxter Healthcare); Sparine (Wyeth).

General Description

Promazine, 10-[3-(dimethylamino) propyl-(phenothiazine monohydrochloride (Sparine), was introducedinto antipsychotic therapy after its 2-chloro-substitutedrelative. The 2H-substituent vis-à-vis the 2Clsubstituent gives a milligram potency decrease as an antipsychotic,as encompassed in Gordon’s rule. Tendency toEPS is also lessened, which may be significant, especially ifit is decreased less than antipsychotic potency.

Synthesis

Promazine, 10-(3-dimethylaminopropyl)phenothiazine (6.1.1), is prepared by the alkylation of phenothiazine with 3-dimethylaminopropylchloride in the presence of sodium amide [1¨C3].

Promazine Preparation Products And Raw materials

Raw materials

Preparation Products

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58-40-2, PromazineRelated Search:

Dimethyl sulfate N,N-Dimethylcyclohexylamine ETHANE Chlorpromazine hydrochloride Dimethyl carbonate Phenothiazine Cyromazine Dimethyl fumarate Imipramine hydrochloride Dimethyl sulfoxide N,N-Dimethylformamide N,N-Dimethyldodecylamine N,N-Dimethylallylamine IMIPRAMINE Dimethyl sulfide Dimethyl ether DIOXOPROMETHAZINE HCL acepromazine

PHENOTHIAZINE,10-(3-(DIMETHYLAMINO)PROPYL)-

N,N-Dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine

dimethyl(3-phenothiazin-10-ylpropyl)amine

Chlorpromazine Impurity 4

A-145

RP-3276

Wy-1094

Promazine

N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine

N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine

Chlorpromazine impurity 1

Chlorpromazine Impurity 3(Chlorpromazine EP Impurity C)

Chlorpromazine-003

10H-Phenothiazine-10-propanamine, N,N-dimethyl-

Promazine USP/EP/BP

Chlorpromazine hydrochloride EP Impurity C

Esparin

NSC 31447

Sinophenin

Promazine Dimer Impurity

58-40-2