Promazine Property

Melting point:

25°C

Boiling point:

bp0.3 203-210°

Density 

1.1256 (rough estimate)

refractive index 

1.6000 (estimate)

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

pKa 9.4(H2O,t =24±1) (Uncertain)

form 

Solid

color 

Off-White to Pale Beige

Water Solubility 

14.22mg/L(24 ºC)

Stability:

Hygroscopic

NIST Chemistry Reference

Promazine(58-40-2)

Safety

Hazardous Substances Data

58-40-2(Hazardous Substances Data)

Toxicity

LD50 oral in rat: 350mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

Promazine Chemical Properties,Usage,Production

Uses

ntipsychotic.

Uses

In psychiatric practice, promazine is used in minor cases of psychomotor excitement in schizophrenics, in paranoid and manic-depressive conditions, for neurosis, alcoholic psychosis, and others. It is sometimes used in anesthesiological practice.

Uses

Promazine is an antipsychotic and a tranquilizer.

Definition

ChEBI: A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.

brand name

Sparine (Baxter Healthcare); Sparine (Wyeth).

General Description

Promazine, 10-[3-(dimethylamino) propyl-(phenothiazine monohydrochloride (Sparine), was introducedinto antipsychotic therapy after its 2-chloro-substitutedrelative. The 2H-substituent vis-à-vis the 2Clsubstituent gives a milligram potency decrease as an antipsychotic,as encompassed in Gordon’s rule. Tendency toEPS is also lessened, which may be significant, especially ifit is decreased less than antipsychotic potency.

Synthesis

Promazine, 10-(3-dimethylaminopropyl)phenothiazine (6.1.1), is prepared by the alkylation of phenothiazine with 3-dimethylaminopropylchloride in the presence of sodium amide [1¨C3].