10-METHYLPHENOTHIAZINE
- Product Name
- 10-METHYLPHENOTHIAZINE
- CAS No.
- 1207-72-3
- Chemical Name
- 10-METHYLPHENOTHIAZINE
- Synonyms
- N-METHYLPHENOTHIAZINE;10-Methyl-10H-phenothiazine;AKOS 93806;10-METHYLPHENOTHIAZINE;2 - Methyl Phenothiazine;Phenothiazine, 10-methyl-;10-Methylphenothiazine>10-Methylphenothiazine,98%;10-Methylphenothiazine 98%;10-methyl-10h-phenothiazin
- CBNumber
- CB0334226
- Molecular Formula
- C13H11NS
- Formula Weight
- 213.3
- MOL File
- 1207-72-3.mol
10-METHYLPHENOTHIAZINE Property
- Melting point:
- 99-101 °C (lit.)
- Boiling point:
- 341.6±12.0 °C(Predicted)
- Density
- 1.1168 (rough estimate)
- refractive index
- 1.5700 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 0.56±0.20(Predicted)
- color
- White to Light yellow
- Water Solubility
- Insoluble in water.
- λmax
- 310nm(CHCl3)(lit.)
- InChI
- InChI=1S/C13H11NS/c1-14-10-6-2-4-8-12(10)15-13-9-5-3-7-11(13)14/h2-9H,1H3
- InChIKey
- QXBUYALKJGBACG-UHFFFAOYSA-N
- SMILES
- C1=C2C(SC3=C(N2C)C=CC=C3)=CC=C1
- CAS DataBase Reference
- 1207-72-3(CAS DataBase Reference)
- EPA Substance Registry System
- 10H-Phenothiazine, 10-methyl- (1207-72-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 425346
- Product name
- 10-Methylphenothiazine
- Purity
- 98%
- Packaging
- 5g
- Price
- $92.2
- Updated
- 2026/03/19
- Product number
- M2517
- Product name
- 10-Methylphenothiazine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $51
- Updated
- 2026/03/19
- Product number
- M354340
- Product name
- 10-Methylphenothiazine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4713AL
- Product name
- 10-Methylphenothiazine
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- 44034
- Product name
- 10-Methylphenothiazine,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 500G
- Price
- $71.65
- Updated
- 2021/12/16
10-METHYLPHENOTHIAZINE Chemical Properties,Usage,Production
Chemical Properties
slightly yellow to pale green crystalline powder
Uses
They are used in pharmaceutical manufacturing especially antipsychotic drugs. Also used as a stabilizer against polymerization of acrylates.
Definition
ChEBI: 10-methylphenothiazine is a member of phenothiazines.
Synthesis
92-84-2
74-88-4
1207-72-3
General procedure for the synthesis of 10-methylphenothiazine from phenothiazine and iodomethane: NaH (60% purity, 1.0 g, 25.1 mmol) was slowly added to a 50 ml round-bottomed flask containing DMF (10 ml) under ice-water bath conditions. Iodomethane (1.3 g, 11.04 mmol) and phenothiazine (2 g, 10.0 mmol) were then added sequentially. The reaction mixture was transferred to room temperature and stirred for 2 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction was quenched by addition of water and extracted with dichloromethane (50 ml x 3). The organic phases were combined and dried with magnesium sulfate and subsequently concentrated to remove the solvent. Purification by silica gel column chromatography afforded the target product 10-methylphenothiazine (2.1 g, white solid) with a melting point of 96 °C in 97% yield.
Purification Methods
Recrystallise it (three times) from EtOH to give the -form (prisms). Recrystallisation from EtOH/*benzene gives the .-form (needles). It has also been purified by vacuum sublimation and is carefulmax 255nm (log 4.60) (pH 6.3) and 255nm in hexane. [Cymerman-Craig & Warburton Aust J Chem 9 294 1956, Beilstein 27 II 33, 27 III/IV 1215.]
References
[1] Molecular Crystals and Liquid Crystals, 2010, vol. 520, p. 36 - 43
[2] Patent: CN106045986, 2016, A. Location in patent: Paragraph 0039; 0040; 0041
[3] Patent: CN106045987, 2016, A. Location in patent: Paragraph 0039; 0040; 0041
[4] Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 1053 - 1056
[5] ACS Chemical Neuroscience, 2017, vol. 8, # 4, p. 798 - 806
10-METHYLPHENOTHIAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 10-METHYLPHENOTHIAZINE manufacturers
- Product
- 10-METHYLPHENOTHIAZINE 1207-72-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 10-Methylphenothiazine 1207-72-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 10-METHYLPHENOTHIAZINE 1207-72-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01