Chloroprocaine hydrochloride

ChemicalBook > CAS DataBase List > Chloroprocaine hydrochloride

Chloroprocaine hydrochloride

Product Name: Chloroprocaine hydrochloride
CAS No.: 3858-89-7
Chemical Name: Chloroprocaine hydrochloride
Synonyms: nesecaine-ce;nesacainehydrochloride;CHLOROPROCAINEHYDROCHLRIDE;Choroprocaine hydrochloride;Tetracaine Solution, 100ppm;chloroprocaine hydrochloride;2-chloroprocainehydrochloride;CHLOROPROCAINE HYDROCHLORIDE (200 MG);Chloroprocaine hydrochloride USP/EP/BP;Chloroprocaine Hydrochloride (1117008)
CBNumber: CB2501642
Molecular Formula: C13H20Cl2N2O2
Formula Weight: 307.2161
MOL File: 3858-89-7.mol

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Chloroprocaine hydrochloride Property

Melting point:: 176-178° (microstage)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Stable. Incompatible with strong oxidizing agents.
InChI: InChI=1S/C13H19ClN2O2.ClH/c1-3-16(4-2)9-10-18-13(17)11-5-7-12(15-14)8-6-11;/h5-8,15H,3-4,9-10H2,1-2H3;1H
InChIKey: KSEXTRRPURJCDW-UHFFFAOYSA-N
SMILES: N(Cl)C1=CC=C(C(=O)OCCN(CC)CC)C=C1.[H]Cl

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Safety

HS Code: 2922492050

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1117008
Product name: Chloroprocaine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $174.4
Updated: 2024/03/01

TRC

Product number: C380265
Product name: Chloroprocaine hydrochloride
Packaging: 10mg
Price: $155
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC152242
Product name: Chloroprocaine HCl
Packaging: 250mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0013536
Product name: Chloroprocaine hydrochloride
Purity: 99.18%
Packaging: 10mg
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC152242
Product name: Chloroprocaine HCl
Packaging: 25mg
Price: $50
Updated: 2021/12/16

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Chloroprocaine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

crystalline solid

Originator

Nesacaine,Astra,US,1956

Uses

Chloroprocaine Hydrochloride is a local anaesthetic compound showing similar effects to Lidocaine.

Uses

Anesthetic (local).

Definition

ChEBI: The monohydrochloride salt of chloroprocaine. Used as a local anaesthetic, particularly for oral surgery, it has the advantage over lidocaine of constricting blood vessels, so reducing bleeding.

Manufacturing Process

In the first step, 2-chloro-4-aminobenzoyl chloride hydrochloride is prepared by refluxing a mixture of 25 cc of purified thionyl chloride and 10 g of 2- chloro-4-aminobenzoic acid until all of the solid has gone into solution. To the cooled solution is added 150 cc of dry ethyl ether. A brisk stream of dry hydrogen chloride is passed into the solution until the precipitation of 2- chloro-4-aminobenzoylchloride hydrochloride is complete. The acyl halide is removed by filtration and dried in a vacuum desiccator.
In the second step, the diethylaminoethyl 2-chloro-4-aminobenzoate hydrochloride is prepared by refluxing equimolar proportions of the hydrochloride of beta-diethylaminoethanol in a suitable inert solvent such as a mixture of dry toluene and tetrachloroethane and the hydrochloride of 2- chloro-4-aminobenzoyl chloride until the reaction as indicated by the cessation of hydrogen chloride evolution is complete. The supernatant solvents are decanted from the reaction product which can be conveniently purified by crystallization from absolute ethanol.
An alternative purification can be effected by dissolving the reaction product in water. The ester base is liberated by rendering the clarified aqueous solution alkaline. Removal of the base from the alkaline solution is achieved by extraction with a suitable solvent such as benzene or ether. The pure hydrochloride of diethylaminoethyl 2-chloro-4-aminobenzoate is then precipitated from the dried extract by the addition of dry hydrogen chloride. After removal by filtration and recrystallization from ethanol it is found to have a melting point of 173° to 174°C.

brand name

Nesacaine (Abraxis).

Therapeutic Function

Local anesthetic

Chloroprocaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Chloroprocaine hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Chloroprocaine hydrochloride 3858-89-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-14

Xiamen Wonderful Bio Technology Co., Ltd.

Product: Chloroprocaine Hydrochloride 3858-89-7
Price: US $88.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 330T
Release date: 2023-07-21

Henan Bao Enluo International TradeCo.，LTD

Product: Chloroprocaine hydrochloride 3858-89-7
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-06-25

3858-89-7, Chloroprocaine hydrochlorideRelated Search:

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CHLOROPROCAINE HYDROCHLORIDE (200 MG)

2-chloroprocainehydrochloride

4-amino-2-chlorobenzoicacid2-(diethylamino)ethylesterhydrochloride

4-Amino-2-Chlorobenzoicacid2-diethylaminoe-thylesterhydrochloride

benzoicacid,4-amino-2-chloro-,2-(diethylamino)ethylester,hydrochloride

nesacainehydrochloride

nesecaine-ce

2-diethylaminoethyl 4-amino-2-chlorobenzoate hydrochloride

chloroprocaine hydrochloride

Choroprocaine hydrochloride

CHLOROPROCAINEHYDROCHLRIDE

4-amino-2-chloro-2-(diethylamino)ethyl benzoic acid ester,hydrochloride (1:1)

Tetracaine Solution, 100ppm

Chloroprocaine hydrochloride USP/EP/BP

3858-89-7 Benzoic acid,4-amino-2-chloro-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)

Chloroprocaine Hydrochloride (1117008)

Chloroprocaine hcl Anesthetic Raw Powder

Chloroprocaine hydrochloride C AS 3858-89-7

inhibit,Na,K-ATPase,Sodium potassium pump,Chloroprocaine,anesthetic,2-Chloroprocaine,Inhibitor,Chloroprocaine hydrochloride,Na+/K+ ATPase

2-Diethylaminoethyl-4-amino-2-chlorbenzoathydrochlorid

3858-89-7

Inhibitors