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Chloroprocaine hydrochloride

Product Name
Chloroprocaine hydrochloride
CAS No.
3858-89-7
Chemical Name
Chloroprocaine hydrochloride
Synonyms
nesecaine-ce;nesacainehydrochloride;CHLOROPROCAINEHYDROCHLRIDE;Choroprocaine hydrochloride;Tetracaine Solution, 100ppm;chloroprocaine hydrochloride;2-chloroprocainehydrochloride;CHLOROPROCAINE HYDROCHLORIDE (200 MG);Chloroprocaine hydrochloride USP/EP/BP;Chloroprocaine Hydrochloride (1117008)
CBNumber
CB2501642
Molecular Formula
C13H20Cl2N2O2
Formula Weight
307.2161
MOL File
3858-89-7.mol
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Chloroprocaine hydrochloride Property

Melting point:
176-178° (microstage)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Stable. Incompatible with strong oxidizing agents.
InChI
InChI=1S/C13H19ClN2O2.ClH/c1-3-16(4-2)9-10-18-13(17)11-5-7-12(15-14)8-6-11;/h5-8,15H,3-4,9-10H2,1-2H3;1H
InChIKey
KSEXTRRPURJCDW-UHFFFAOYSA-N
SMILES
N(Cl)C1=CC=C(C(=O)OCCN(CC)CC)C=C1.[H]Cl
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Safety

HS Code 
2922492050
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1117008
Product name
Chloroprocaine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$174.4
Updated
2024/03/01
TRC
Product number
C380265
Product name
Chloroprocaine hydrochloride
Packaging
10mg
Price
$155
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC152242
Product name
Chloroprocaine HCl
Packaging
250mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0013536
Product name
Chloroprocaine hydrochloride
Purity
99.18%
Packaging
10mg
Price
$240
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC152242
Product name
Chloroprocaine HCl
Packaging
25mg
Price
$50
Updated
2021/12/16
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Chloroprocaine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

crystalline solid

Originator

Nesacaine,Astra,US,1956

Uses

Chloroprocaine Hydrochloride is a local anaesthetic compound showing similar effects to Lidocaine.

Uses

Anesthetic (local).

Definition

ChEBI: The monohydrochloride salt of chloroprocaine. Used as a local anaesthetic, particularly for oral surgery, it has the advantage over lidocaine of constricting blood vessels, so reducing bleeding.

Manufacturing Process

In the first step, 2-chloro-4-aminobenzoyl chloride hydrochloride is prepared by refluxing a mixture of 25 cc of purified thionyl chloride and 10 g of 2- chloro-4-aminobenzoic acid until all of the solid has gone into solution. To the cooled solution is added 150 cc of dry ethyl ether. A brisk stream of dry hydrogen chloride is passed into the solution until the precipitation of 2- chloro-4-aminobenzoylchloride hydrochloride is complete. The acyl halide is removed by filtration and dried in a vacuum desiccator.
In the second step, the diethylaminoethyl 2-chloro-4-aminobenzoate hydrochloride is prepared by refluxing equimolar proportions of the hydrochloride of beta-diethylaminoethanol in a suitable inert solvent such as a mixture of dry toluene and tetrachloroethane and the hydrochloride of 2- chloro-4-aminobenzoyl chloride until the reaction as indicated by the cessation of hydrogen chloride evolution is complete. The supernatant solvents are decanted from the reaction product which can be conveniently purified by crystallization from absolute ethanol.
An alternative purification can be effected by dissolving the reaction product in water. The ester base is liberated by rendering the clarified aqueous solution alkaline. Removal of the base from the alkaline solution is achieved by extraction with a suitable solvent such as benzene or ether. The pure hydrochloride of diethylaminoethyl 2-chloro-4-aminobenzoate is then precipitated from the dried extract by the addition of dry hydrogen chloride. After removal by filtration and recrystallization from ethanol it is found to have a melting point of 173° to 174°C.

brand name

Nesacaine (Abraxis).

Therapeutic Function

Local anesthetic

Chloroprocaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Chloroprocaine hydrochloride Suppliers

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View Lastest Price from Chloroprocaine hydrochloride manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.
Product
Chloroprocaine Hydrochloride 3858-89-7
Price
US $88.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
330T
Release date
2023-07-21
Henan Bao Enluo International TradeCo.，LTD
Product
Chloroprocaine hydrochloride 3858-89-7
Price
US $150.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-06-25
Dideu Industries Group Limited
Product
Chloroprocaine hydrochloride 3858-89-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-08

3858-89-7, Chloroprocaine hydrochlorideRelated Search:

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