Carbasalate calcium
Uses- Product Name
- Carbasalate calcium
- CAS No.
- 5749-67-7
- Chemical Name
- Carbasalate calcium
- Synonyms
- Omegin;Alcacyl;Rheomin;Solupsan;Carbaspirin;Complex with urea;arbasalate calcium;Carbasalate Calium;Carbasalac Calcium;Carbaslate Calcium
- CBNumber
- CB2512132
- Molecular Formula
- C10H14CaN2O5
- Formula Weight
- 282.31
- MOL File
- 5749-67-7.mol
Carbasalate calcium Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Freely soluble in water and in dimethylformamide, practically insoluble in acetone and in anhydrous methanol.
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C9H8O4.CH4N2O.Ca.2H/c1-6(10)13-8-5-3-2-4-7(8)9(11)12;2-1(3)4;;;/h2-5H,1H3,(H,11,12);(H4,2,3,4);;;
- InChIKey
- BMMIBWSFPSYDEH-UHFFFAOYSA-N
- SMILES
- C(=O)(N)N.C(C1C=CC=CC=1OC(=O)C)(=O)O.[Ca]
- CAS DataBase Reference
- 5749-67-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 29806
- Product name
- Carbasalate Calcium
- Packaging
- 1g
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 29806
- Product name
- Carbasalate Calcium
- Packaging
- 10g
- Price
- $669
- Updated
- 2024/03/01
- Product number
- 29806
- Product name
- Carbasalate Calcium
- Packaging
- 500mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 29806
- Product name
- Carbasalate Calcium
- Packaging
- 5g
- Price
- $435
- Updated
- 2024/03/01
- Product number
- FC147061
- Product name
- Carbasalatecalcium
- Packaging
- 50g
- Price
- $411
- Updated
- 2021/12/16
Carbasalate calcium Chemical Properties,Usage,Production
Uses
Carbasalate Calcium is an analgesic, antipyretic, and anti-inflammatory drug.
Description
Carbasalate calcium is a calcium-urea chelate of aspirin that has analgesic, anti-inflammatory, and antipyretic effects. It reduces carrageenan-induced paw edema in rats.
Chemical Properties
White or almost white, crystalline powder.
Originator
Calurin,Dorsey,US,1959
Uses
Salicylate; non-selective cyclo-oxygenase inhibitor; antipyretic; analgesic; antiinflammatory.
Uses
Carbasalate Calcium is an analgesic, antipyretic, and anti-inflammatory drug.
Manufacturing Process
500 g of finely powdered acetylsalicylic acid and 160 g of calcium carbonate (precipitated chalk), are intimately mixed and 3,000 cc of water are added. The mixture is stirred for 15 minutes or until the reaction is completed, which is indicated by the cessation of the liberation of carbon dioxide. The temperature is desirably maintained below 20°C by any suitable means. The mass is allowed to settle until the supernatant liquor is almost clear; this usually takes about 5 minutes, and the mixture is then filtered to remove unreacted material. This part of the process is carried out as quickly as possible so as to minimize any tendency of the calcium aspirin to hydrolyze in the solution. The filtrate is cooled to about 10°C and 1 to 1.5 volumes of 97% methanol, or pure wood alcohol is added. This causes the calcium aspirin to precipitate and the mass is then filtered to remove as thoroughly as possible the mother liquor. The residue of calcium aspirin is then suspended in a quantity of methanol equivalent to the volume previously used as a precipitant, and it is allowed to stand there for one hour or more with occasional or continuous agitation. The mass is again filtered, the filtrate being employed for the precipitation of calcium aspirin in a later batch. After the filtering of the first wash liquor, the calcium aspirin is again suspended in another quantity of methanol of an equivalent volume. This constitutes the second wash and it is carried out in the same way as the first wash. The filtrate is employed as a first wash in a later batch and this filtrate in turn is used, as is the filtrate of the first wash, for the precipitation of more calcium aspirin. Fresh alcohol is used as a new wash in a later batch and the washes are carried out in series. After the second wash the calcium aspirin is dried in a suitable manner, as by passing dry warm air over it, the temperature not being allowed to rise to such an extent as to decompose the aspirin; preferably the temperature is not permitted to rise above 50°C, but should be high enough to avoid deposition of water vapor, and the drying is completed when there is no longer an odor of methanol.
Therapeutic Function
Analgesic, Antipyretic, Antirheumatic
Mechanism of action
Carbasalate calcium is a non-steroidal anti-inflammatory drug. In addition to their anti-inflammatory effects, they are analgesic, antipyretic and platelet inhibitory. They block prostaglandin synthesis by inhibiting the enzyme cyclooxygenase, which converts arachidonic acid into cyclic endoperoxide, the precursor of prostaglandins. Inhibition of prostaglandin synthesis is responsible for their analgesic, antipyretic, and platelet-inhibitory effects; other mechanisms may contribute to their anti-inflammatory effects.
Carbasalate calcium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Carbasalate calcium manufacturers
- Product
- Carbasalate calcium 5749-67-7
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- ＞98.0%
- Supply Ability
- 10tons
- Release date
- 2024-04-26
- Product
- Carbasalate calcium 5749-67-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2022-09-21
- Product
- Carbaspirin calcium 5749-67-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 5 TON
- Release date
- 2023-07-06