Uses
ChemicalBook > CAS DataBase List > Carbasalate calcium

Carbasalate calcium

Uses
Product Name
Carbasalate calcium
CAS No.
5749-67-7
Chemical Name
Carbasalate calcium
Synonyms
Omegin;Alcacyl;Rheomin;Solupsan;Carbaspirin;Complex with urea;arbasalate calcium;Carbasalate Calium;Carbasalac Calcium;Carbaslate Calcium
CBNumber
CB2512132
Molecular Formula
C10H14CaN2O5
Formula Weight
282.31
MOL File
5749-67-7.mol
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Carbasalate calcium Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
Freely soluble in water and in dimethylformamide, practically insoluble in acetone and in anhydrous methanol.
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C9H8O4.CH4N2O.Ca.2H/c1-6(10)13-8-5-3-2-4-7(8)9(11)12;2-1(3)4;;;/h2-5H,1H3,(H,11,12);(H4,2,3,4);;;
InChIKey
BMMIBWSFPSYDEH-UHFFFAOYSA-N
SMILES
C(=O)(N)N.C(C1C=CC=CC=1OC(=O)C)(=O)O.[Ca]
CAS DataBase Reference
5749-67-7
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29806
Product name
Carbasalate Calcium
Packaging
1g
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
29806
Product name
Carbasalate Calcium
Packaging
10g
Price
$669
Updated
2024/03/01
Cayman Chemical
Product number
29806
Product name
Carbasalate Calcium
Packaging
500mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
29806
Product name
Carbasalate Calcium
Packaging
5g
Price
$435
Updated
2024/03/01
Biosynth Carbosynth
Product number
FC147061
Product name
Carbasalatecalcium
Packaging
50g
Price
$411
Updated
2021/12/16
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Carbasalate calcium Chemical Properties,Usage,Production

Uses

Carbasalate Calcium is an analgesic, antipyretic, and anti-inflammatory drug.

Description

Carbasalate calcium is a calcium-urea chelate of aspirin that has analgesic, anti-inflammatory, and antipyretic effects. It reduces carrageenan-induced paw edema in rats.

Chemical Properties

White or almost white, crystalline powder.

Originator

Calurin,Dorsey,US,1959

Uses

Salicylate; non-selective cyclo-oxygenase inhibitor; antipyretic; analgesic; antiinflammatory.

Uses

Carbasalate Calcium is an analgesic, antipyretic, and anti-inflammatory drug.

Manufacturing Process

500 g of finely powdered acetylsalicylic acid and 160 g of calcium carbonate (precipitated chalk), are intimately mixed and 3,000 cc of water are added. The mixture is stirred for 15 minutes or until the reaction is completed, which is indicated by the cessation of the liberation of carbon dioxide. The temperature is desirably maintained below 20°C by any suitable means. The mass is allowed to settle until the supernatant liquor is almost clear; this usually takes about 5 minutes, and the mixture is then filtered to remove unreacted material. This part of the process is carried out as quickly as possible so as to minimize any tendency of the calcium aspirin to hydrolyze in the solution. The filtrate is cooled to about 10°C and 1 to 1.5 volumes of 97% methanol, or pure wood alcohol is added. This causes the calcium aspirin to precipitate and the mass is then filtered to remove as thoroughly as possible the mother liquor. The residue of calcium aspirin is then suspended in a quantity of methanol equivalent to the volume previously used as a precipitant, and it is allowed to stand there for one hour or more with occasional or continuous agitation. The mass is again filtered, the filtrate being employed for the precipitation of calcium aspirin in a later batch. After the filtering of the first wash liquor, the calcium aspirin is again suspended in another quantity of methanol of an equivalent volume. This constitutes the second wash and it is carried out in the same way as the first wash. The filtrate is employed as a first wash in a later batch and this filtrate in turn is used, as is the filtrate of the first wash, for the precipitation of more calcium aspirin. Fresh alcohol is used as a new wash in a later batch and the washes are carried out in series. After the second wash the calcium aspirin is dried in a suitable manner, as by passing dry warm air over it, the temperature not being allowed to rise to such an extent as to decompose the aspirin; preferably the temperature is not permitted to rise above 50°C, but should be high enough to avoid deposition of water vapor, and the drying is completed when there is no longer an odor of methanol.

Therapeutic Function

Analgesic, Antipyretic, Antirheumatic

Mechanism of action

Carbasalate calcium is a non-steroidal anti-inflammatory drug. In addition to their anti-inflammatory effects, they are analgesic, antipyretic and platelet inhibitory. They block prostaglandin synthesis by inhibiting the enzyme cyclooxygenase, which converts arachidonic acid into cyclic endoperoxide, the precursor of prostaglandins. Inhibition of prostaglandin synthesis is responsible for their analgesic, antipyretic, and platelet-inhibitory effects; other mechanisms may contribute to their anti-inflammatory effects.

Carbasalate calcium Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbasalate calcium Suppliers

Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586 13210588999
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
193
Advantage
58
Jinan Yunding Biotechnology Co., Ltd
Tel
15662712965
Email
1013429786@qq.com
Country
China
ProdList
22
Advantage
58
Shandong Jihao Biotechnology Co., Ltd.
Tel
0531-69958659 15668363232
Email
8598038@qq.com
Country
China
ProdList
45
Advantage
58
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Fax
+86-556-5032307
Email
wtx@bayeebio.com
Country
China
ProdList
265
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2876
Advantage
58
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View Lastest Price from Carbasalate calcium manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Carbasalate calcium 5749-67-7
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-01
Hangzhou Hyper Chemicals Limited
Product
Carbasalate calcium 5749-67-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5,000KG
Release date
2024-08-14
Hebei Yanxi Chemical Co., Ltd.
Product
Carbasalate calcium 5749-67-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98.00%
Supply Ability
20tons
Release date
2023-09-20

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