BENORILATE
- Product Name
- BENORILATE
- CAS No.
- 5003-48-5
- Chemical Name
- BENORILATE
- Synonyms
- to125;benoral;benortan;salipran;win11450;Benno fat;benorilato;Fenasprate;BENORILATE;BENORYLATE
- CBNumber
- CB2397764
- Molecular Formula
- C17H15NO5
- Formula Weight
- 313.3
- MOL File
- 5003-48-5.mol
BENORILATE Property
- Melting point:
- 177-181℃
- Boiling point:
- 453.11°C (rough estimate)
- Density
- 1.2016 (rough estimate)
- refractive index
- 1.4500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 14.17±0.70(Predicted)
- form
- Solid
- color
- White
- Water Solubility
- 20mg/L(21 ºC)
- Merck
- 14,1045
- CAS DataBase Reference
- 5003-48-5(CAS DataBase Reference)
Safety
- RTECS
- VO0720000
- HS Code
- 2924.29.7790
- Toxicity
- LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B4827
- Product name
- Benorilate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $29
- Updated
- 2024/03/01
- Product number
- B4827
- Product name
- Benorilate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $83
- Updated
- 2024/03/01
- Product number
- B165700
- Product name
- Benorilate
- Packaging
- 25g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 162750
- Product name
- Benorilate
- Packaging
- 1g
- Price
- $403
- Updated
- 2021/12/16
- Product number
- 68003
- Product name
- Benorilate
- Packaging
- 10g
- Price
- $650
- Updated
- 2021/12/16
BENORILATE Chemical Properties,Usage,Production
Description
Benorylate is the acetaminophen ester of acetylsalicylic acid, designed to provide a less irritating form of aspirin. Gastrointestinal blood loss in patients taking benorylate is less than that during therapy with soluble aspirin. Benorylate has been found to be as effective as aspirin for the treatment of chronic rheumatic disorders.
Originator
Benortan,Winthrop,Switz.
Uses
Benorilate is a codrug of Acetylsalicylic Acid (A187780) and Acetaminophen (A161220) and is used as an anti-inflammatory and antipyretic medication.
Definition
ChEBI: Benorilate is a carbonyl compound.
Manufacturing Process
Example 1: 65 grams of N-acetyl-p-aminophenol were slurried with 400 ml of
water and cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly
added to the mixture with stirring, the temperature being maintained between
10°and 15°C. To the solution obtained, 75 grams of acetyl salicoyl chloride
were added with vigorous stirring over a period of 1/2 hr, the solution being
maintained at a temperature of about 10°C. Towards the end of the reaction
the pH was checked and adjusted to greater than 10 by the addition of a
small amount of 20% sodium hydroxide. After all the acid chloride had been
added, vigorous stirring was continued for half an hour during which time the
crude product separated out. This product was filtered off, washed thoroughly
with water and recrystallized from ethanol.
Example 2: 65 grams of sodium N-acetyl-p-aminophenol were slurried with
500 grams of dry benzene and 80 grams of acetyl salicoyl chloride added. The
mixture was heated under reflux for four hours and filtered hot. The excess
benzene was removed under vacuum and the crude acetyl salicyclic acid ester
of N-acetyl-p-aminophenol crystallized from ethanol.
brand name
Benoral (Sterling Winthrop);Benolat;Benorile;Benotamol;Bentum;Doline;Durium;Duvium;Faw 76;Quinexin;Sinalgin;Spierifex;Triadol;Vetedol;Win 11450;Winolate;Winorlate;Winorylate;Winrolate;Wiolate.
Therapeutic Function
Analgesic, Antiinflammatory, Antipyretic
World Health Organization (WHO)
Benorilate is the acetylsalicylic ester of paracetamol. See WHO comment for acetylsalicylic acid.
BENORILATE Preparation Products And Raw materials
Raw materials
Preparation Products
BENORILATE Suppliers
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View Lastest Price from BENORILATE manufacturers
- Product
- Benorilate 5003-48-5
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 99.912%
- Supply Ability
- 10ton
- Release date
- 2024-04-24
- Product
- Benorilate 5003-48-5
- Price
- US $100.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-03-06
- Product
- BENORILATE 5003-48-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-04-17