ChemicalBook > CAS DataBase List > BENORILATE

BENORILATE

Product Name
BENORILATE
CAS No.
5003-48-5
Chemical Name
BENORILATE
Synonyms
to125;benoral;benortan;salipran;win11450;Benno fat;benorilato;Fenasprate;BENORILATE;BENORYLATE
CBNumber
CB2397764
Molecular Formula
C17H15NO5
Formula Weight
313.3
MOL File
5003-48-5.mol
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BENORILATE Property

Melting point:
177-181℃
Boiling point:
453.11°C (rough estimate)
Density 
1.2016 (rough estimate)
refractive index 
1.4500 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
14.17±0.70(Predicted)
form 
Solid
color 
White
Water Solubility 
20mg/L(21 ºC)
Merck 
14,1045
CAS DataBase Reference
5003-48-5(CAS DataBase Reference)
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Safety

RTECS 
VO0720000
HS Code 
2924.29.7790
Toxicity
LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4827
Product name
Benorilate
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
B4827
Product name
Benorilate
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$83
Updated
2024/03/01
TRC
Product number
B165700
Product name
Benorilate
Packaging
25g
Price
$225
Updated
2021/12/16
Usbiological
Product number
162750
Product name
Benorilate
Packaging
1g
Price
$403
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
68003
Product name
Benorilate
Packaging
10g
Price
$650
Updated
2021/12/16
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BENORILATE Chemical Properties,Usage,Production

Description

Benorylate is the acetaminophen ester of acetylsalicylic acid, designed to provide a less irritating form of aspirin. Gastrointestinal blood loss in patients taking benorylate is less than that during therapy with soluble aspirin. Benorylate has been found to be as effective as aspirin for the treatment of chronic rheumatic disorders.

Originator

Benortan,Winthrop,Switz.

Uses

Benorilate is a codrug of Acetylsalicylic Acid (A187780) and Acetaminophen (A161220) and is used as an anti-inflammatory and antipyretic medication.

Definition

ChEBI: Benorilate is a carbonyl compound.

Manufacturing Process

Example 1: 65 grams of N-acetyl-p-aminophenol were slurried with 400 ml of water and cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly added to the mixture with stirring, the temperature being maintained between 10°and 15°C. To the solution obtained, 75 grams of acetyl salicoyl chloride were added with vigorous stirring over a period of 1/2 hr, the solution being maintained at a temperature of about 10°C. Towards the end of the reaction the pH was checked and adjusted to greater than 10 by the addition of a small amount of 20% sodium hydroxide. After all the acid chloride had been added, vigorous stirring was continued for half an hour during which time the crude product separated out. This product was filtered off, washed thoroughly with water and recrystallized from ethanol.
Example 2: 65 grams of sodium N-acetyl-p-aminophenol were slurried with 500 grams of dry benzene and 80 grams of acetyl salicoyl chloride added. The mixture was heated under reflux for four hours and filtered hot. The excess benzene was removed under vacuum and the crude acetyl salicyclic acid ester of N-acetyl-p-aminophenol crystallized from ethanol.

brand name

Benoral (Sterling Winthrop);Benolat;Benorile;Benotamol;Bentum;Doline;Durium;Duvium;Faw 76;Quinexin;Sinalgin;Spierifex;Triadol;Vetedol;Win 11450;Winolate;Winorlate;Winorylate;Winrolate;Wiolate.

Therapeutic Function

Analgesic, Antiinflammatory, Antipyretic

World Health Organization (WHO)

Benorilate is the acetylsalicylic ester of paracetamol. See WHO comment for acetylsalicylic acid.

BENORILATE Preparation Products And Raw materials

Raw materials

Acetamide Acetylsalicylic acid O-ACETYLSALICYLOYL CHLORIDE

Preparation Products

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BENORILATE Suppliers

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View Lastest Price from BENORILATE manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Benorilate 5003-48-5
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-11
Hebei Weibang Biotechnology Co., Ltd
Product
BENORILATE 5003-48-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Liaoning Pharmaceutical Innovation Co., Ltd
Product
Benorilate 5003-48-5
Price
US $100.00-1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-03-06

5003-48-5, BENORILATERelated Search:

Glucosamine sulfate Dextromethorphan ASPIRIN ALUMINIUM Acetylsalicylic acid PU 122 Clofibrate Nisoldipine Pentoxyverine Digitoxin Procysteine Loperamide Acetaminophen Ambroxol 2-[[2-[[2-(Acetyloxy)benzoyl]oxy]benzoyl]oxy]benzoic Acid 2-[[2-[(2-carboxyphenoxy)carbonyl]phenoxy]carbonyl]phenyl Ester 2-HYDROXYBENZOIC-3,4,5,6-D4 ACID 1-[bis(4-fluorophenyl)methyl]-2,2,3,3,5,5,6,6-octadeuterio-4-[3-(3,4-dimethoxyphenyl)prop-2-enyl]piperazine 2-[[2-(Acetyloxy)benzoyl]oxy]benzoic Acid 2-[(2-Carboxyphenoxy)carbonyl]phenyl Ester 5-ACETYLSALICYLIC ACID

  • 2-acetoxy-4’-(acetamino)phenylbenzoate
  • 4’-(acetamido)phenyl-2-acetoxybenzoate
  • aspirinacetaminophenester
  • benoral
  • benorilato
  • benortan
  • fenasparate
  • p-acetamidophenylacetylsalicylate
  • p-n-acetylaminophenylacetylsalicylate
  • salicylicacid,acetate,esterwith4’-hydroxyacetanilide
  • Salicylicacidacetate4’-hydroxyace-etanilideester
  • salipran
  • to125
  • win11450
  • 4-acetamidophenyl O-acetylsalicylate
  • BENORYLATUM
  • Benzoic acid, 2-(acetyloxy)-, 4-(acetylaMino)phenyl ester
  • Fenasprate
  • (4-acetamidophenyl) 2-acetyloxybenzoate
  • 2-acetoxybenzoic acid (4-acetamidophenyl) ester
  • 2-Acetoxybenzoic acid 4(acetylamino)phenyl ester
  • Benno fat
  • BENORILATE
  • BENORYLATE
  • BENORYLATE HYDROCHLORIDE
  • 2-(acetyloxy)-benzoicaci4-(acetylamino)phenylester
  • 2-(acetyloxy)benzoicacid4-(acetylamino)phenylester
  • 2-(Acetyloxyl)benzoicacid4-(acetylamino)phenylester
  • Chloro-sibutramine Solution, 100ppm
  • Benorilate &gt
  • Benorilate Benorilate
  • Acetylsalicylic Acid Impurity 28
  • BENORILATE USP/EP/BP
  • BenorilateQ: What is Benorilate Q: What is the CAS Number of Benorilate Q: What is the storage condition of Benorilate
  • Benno ester
  • Benorilate/2-Acetoxybenzoic acid 4(acetylamino)phenyl ester
  • Baricitinib Impurity 69
  • Benozyl ester
  • Benortan|||Benoral|||Salipran|||Benorylate
  • 5003-48-5
  • C17H15N05
  • API