ChemicalBook > CAS DataBase List > GSK3145095

GSK3145095

Product Name: GSK3145095
CAS No.: 1622849-43-7
Chemical Name: GSK3145095
Synonyms: GSK3145095;GSK3145095, 10 mM in DMSO;RIPK1 inhibitor GS3145095;Inhibitor,GSK3145095,inhibit,RIP kinase,GSK-3145095,Receptor-interacting protein kinases,RIPK,GSK 3145095;(S)-5-Benzyl-N-(7,9-difluoro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-4H-1,2,4-triazole-3-carboxamide;1H-1,2,4-Triazole-5-carboxamide, N-[(3S)-7,9-difluoro-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-3-(phenylmethyl)-
CBNumber: CB25417582
Molecular Formula: C20H17F2N5O2
Formula Weight: 397.38
MOL File: 1622849-43-7.mol

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GSK3145095 Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:164.5(Max Conc. mg/mL);413.96(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);15.1(Max Conc. mM)
form: Solid
pka: 8.82±0.40(Predicted)
color: White to off-white
InChIKey: ATQAGKAMBISZQM-HNNXBMFYSA-N
SMILES: N1C(C(N[C@H]2CCC3=CC(F)=CC(F)=C3NC2=O)=O)=NC(CC2=CC=CC=C2)=N1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611941
Product name: RIPK1 inhibitor GS3145095
Purity: >98%
Packaging: 100mg
Price: $1431.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611941
Product name: RIPK1 inhibitor GS3145095
Purity: >98%
Packaging: 250mg
Price: $2541.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611941
Product name: RIPK1 inhibitor GS3145095
Purity: >98%
Packaging: 1g
Price: $5062.6
Updated: 2021/12/16

DC Chemicals

Product number: DC26011
Product name: GSK3145095
Purity: >98%
Packaging: 250mg
Price: $1700
Updated: 2021/12/16

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GSK3145095 Chemical Properties,Usage,Production

Uses

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].

References

[1] Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10(6):857-862. DOI:10.1021/acsmedchemlett.9b00108

GSK3145095 Preparation Products And Raw materials

Raw materials

Preparation Products

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1622849-43-7, GSK3145095Related Search:

GSK3008348 2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate GSK2983559 cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate GSK3175047 GSK2982772 GSK2894631A GSK-2881078 N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide GSK3039294

GSK3145095

RIPK1 inhibitor GS3145095

1H-1,2,4-Triazole-5-carboxamide, N-[(3S)-7,9-difluoro-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-3-(phenylmethyl)-

Inhibitor,GSK3145095,inhibit,RIP kinase,GSK-3145095,Receptor-interacting protein kinases,RIPK,GSK 3145095

(S)-5-Benzyl-N-(7,9-difluoro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

GSK3145095, 10 mM in DMSO

1622849-43-7

C20H17F2N5O2