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cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate

Product Name
cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate
CAS No.
1018673-42-1
Chemical Name
cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate
Synonyms
CS-2158;CS-2598;CHR5154;CHR-5154;HDAC-IN-3;GSK3117391;GSK3117391A;HDAC inhibitor 3;CHR-5154; CHR5154;GSK 3117391;GSK-3117391
CBNumber
CB63037595
Molecular Formula
C22H33N3O4
Formula Weight
403.52
MOL File
1018673-42-1.mol
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cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate Property

storage temp. 
Store at -20°C
solubility 
DMSO:81.0(Max Conc. mg/mL);200.73(Max Conc. mM)
Ethanol:15.0(Max Conc. mg/mL);37.17(Max Conc. mM)
form 
A crystalline solid
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23846
Product name
GSK3117391
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
23846
Product name
GSK3117391
Packaging
10mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
23846
Product name
GSK3117391
Packaging
25mg
Price
$365
Updated
2024/03/01
Cayman Chemical
Product number
23846
Product name
GSK3117391
Packaging
50mg
Price
$547
Updated
2024/03/01
ChemScene
Product number
CS-5448
Product name
HDAC-IN-3
Purity
98.86%
Packaging
10mg
Price
$600
Updated
2021/12/16
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cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate Chemical Properties,Usage,Production

Description

GSK3117391 is a histone deacetylase (HDAC) inhibitor (IC50 = <100 nM in HeLa nuclear extracts). It inhibits growth of U937 and HUT cancer cells (IC50s = <330 nM).

Uses

GSK3117391 (ESM-HDAC391) is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2008040934 A1. Target: HDAC

IC 50

HDAC

References

[1] Davidson Alan Hornsby, et al. Preparation of amino acid-based hydroxamic acids as histone deacetylase (HDAC) inhibitors. From PCT Int. Appl. (2008), WO 2008040934 A1 20080410.

cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate Suppliers

China 47 United States 8 Global 55
MedChemexpress LLC
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021-58955995
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609-228-5909
Email
sales@medchemexpress.cn
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United States
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CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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Shanghai Changyan Chem & Tech Co., Ltd.
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021-20242659 18930833303
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+86 (21) 2024-2659
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Sales@changyanchem.cn
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China
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Qingdao IniKem BioPharmaTech Co.,Ltd
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0532-58268780
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 17801761073
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3193328036@qq.com
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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Medi-tech Bioscientific Co., Ltd.
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0519-83246372 13585352506
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0519-83246372
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China
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Chuzhou KeMail Chemical Technology Co., Ltd
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0550-5196001 15000891977
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0550-5196001
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wj520wjxby@126.com
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1018673-42-1, cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetateRelated Search:

GSK3008348 2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate GSK2983559 GSK3175047 GSK2982772 GSK2894631A GSK-2881078 N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide GSK3145095 GSK3039294

  • cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate
  • HDAC-IN-3
  • GSK3117391A
  • GSK3117391
  • GSK 3117391;GSK-3117391
  • HDAC inhibitor 3
  • CHR5154
  • CHR-5154
  • CHR-5154; CHR5154
  • CS-2598
  • CS-2158
  • Cyclohexyl-{[6-(2-hydroxycarbamoyl-ethyl)-pyridin-3-ylmethyl]-amino}-acetic acid cyclopentyl ester
  • Cyclohexaneacetic acid, α-[[[6-[3-(hydroxyamino)-3-oxopropyl]-3-pyridinyl]methyl]amino]-, cyclopentyl ester, (αS)-
  • Cyclohexaneaceticacid,α-[[[6-[3-(hydroxyamino)-3-oxopropyl]-3-pyridinyl]methyl]amino]-,cyclopentylester,(αS)-
  • Histone deacetylases,Inhibitor,inhibit,HDAC,HDACIN3,HDAC IN 3
  • Cyclopentyl (S)-2-cyclohexyl-2-(((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methyl)amino)acetate
  • HDAC-IN-3, 10 mM in DMSO
  • 1018673-42-1