GSK3145095

Product Name: GSK3145095
CAS No.: 1622849-43-7
Chemical Name: GSK3145095
Synonyms: GSK3145095;GSK3145095, 10 mM in DMSO;RIPK1 inhibitor GS3145095;Inhibitor,GSK3145095,inhibit,RIP kinase,GSK-3145095,Receptor-interacting protein kinases,RIPK,GSK 3145095;(S)-5-Benzyl-N-(7,9-difluoro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-4H-1,2,4-triazole-3-carboxamide;1H-1,2,4-Triazole-5-carboxamide, N-[(3S)-7,9-difluoro-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-3-(phenylmethyl)-
CBNumber: CB25417582
Molecular Formula: C20H17F2N5O2
Formula Weight: 397.38
MOL File: 1622849-43-7.mol

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GSK3145095 Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:164.5(Max Conc. mg/mL);413.96(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);15.1(Max Conc. mM)
form: Solid
pka: 8.82±0.40(Predicted)
color: White to off-white
InChIKey: ATQAGKAMBISZQM-HNNXBMFYSA-N
SMILES: N1C(C(N[C@H]2CCC3=CC(F)=CC(F)=C3NC2=O)=O)=NC(CC2=CC=CC=C2)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611941
Product name: RIPK1 inhibitor GS3145095
Purity: >98%
Packaging: 100mg
Price: $1431.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611941
Product name: RIPK1 inhibitor GS3145095
Purity: >98%
Packaging: 250mg
Price: $2541.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611941
Product name: RIPK1 inhibitor GS3145095
Purity: >98%
Packaging: 1g
Price: $5062.6
Updated: 2021/12/16

DC Chemicals

Product number: DC26011
Product name: GSK3145095
Purity: >98%
Packaging: 250mg
Price: $1700
Updated: 2021/12/16

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GSK3145095 Chemical Properties,Usage,Production

Uses

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].

References

[1] Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10(6):857-862. DOI:10.1021/acsmedchemlett.9b00108

GSK3145095 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK3145095 Suppliers

China 49 United States 3 Global 52

Fujian boshi pharmaceutical technology co. LTD

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1622849-43-7, GSK3145095Related Search:

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GSK3145095

RIPK1 inhibitor GS3145095

1H-1,2,4-Triazole-5-carboxamide, N-[(3S)-7,9-difluoro-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-3-(phenylmethyl)-

Inhibitor,GSK3145095,inhibit,RIP kinase,GSK-3145095,Receptor-interacting protein kinases,RIPK,GSK 3145095

(S)-5-Benzyl-N-(7,9-difluoro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

GSK3145095, 10 mM in DMSO

1622849-43-7

C20H17F2N5O2