ChemicalBook > CAS DataBase List > NIK SMI1

NIK SMI1

Product Name: NIK SMI1
CAS No.: 1660114-31-7
Chemical Name: NIK SMI1
Synonyms: NIK SMI1;NIK SMI1, 10 mM in DMSO;NIK inhibitor 4f(NIK SMI1);4-methoxy-6-(3-methylphenyl)pyridine-2-carboxamide;(R)-6-(3-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide;NIK SMI1,Nuclear factor-κB,NIK SMI 1,Nuclear factor-kappaB,inhibit,Inhibitor,NF-κB,NIK SMI-1;2-Pyridinecarboxamide, 6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxo-3-pyrrolidinyl]ethynyl]phenyl]-4-methoxy-
CBNumber: CB25419793
Molecular Formula: C20H19N3O4
Formula Weight: 365.38
MOL File: 1660114-31-7.mol

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NIK SMI1 Property

Boiling point:: 626.7±55.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (273.69 mM)
form: Solid
pka: 11.14±0.20(Predicted)
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3129
Product name: NIK SMI1
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $259
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3129
Product name: NIK SMI1
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $794
Updated: 2025/07/31

ChemScene

Product number: CS-0046051
Product name: NIKSMI1
Purity: 99.01%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0046051
Product name: NIKSMI1
Purity: 99.01%
Packaging: 50mg
Price: $2650
Updated: 2021/12/16

DC Chemicals

Product number: DC10927
Product name: NIKinhibitor4f(NIKSMI1)
Purity: >98%
Packaging: 250mg
Price: $2000
Updated: 2021/12/16

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NIK SMI1 Chemical Properties,Usage,Production

Uses

NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor.

Biological Activity

NIK SMI1 is an orally active, ATP site-targeting, potent and selective NF-KB-inducing kinase inhibitor (h/m NIK IC50 = 230/395 pM; hKHS1/hPKD1/hLRRK2 = 49.6/75.2/247.8 nM) th at selectively disrupts noncanonical NF-KB signaling (anti-LTβR-induced p52 nuclear translocation IC50 = 70 nM; TNFα-induced p65 RelA nuclear translocation IC50 >2 μM). SMI1 inhibits BAFF receptor- and CD40-mediated singling in cultures (human and murine B-cells) and shows in vivo efficacy in the NZB/W F1 murine experimental lupus model (6-400 mg/kg/day, b.i.d. p.o.).

in vivo

C57BL/6 mice are treated twice daily for 7 days with orally administered NIK SMI1 or with three injections of recombinant BAFF receptor fusion protein (Br3- mIgG2a) over the course of the 7-day experiment as a positive control. The nonlinearity of exposure relative to dose between 100 and 200 mg/kg is a result of saturation of clearance mechanisms. The pharmacology of NIK SMI1 is examined in SD rat, CD-1 mouse, beagle, and cynomologous monkey with 20, 32, 18, and 7.8 mL/kg per min, respectively. Volume of distribution (Vd, L/kg) is 1.35, 1.58, 0.778, and 1.39, respectively^[1].

NIK SMI1 Preparation Products And Raw materials

Raw materials

Preparation Products

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1660114-31-7, NIK SMI1Related Search:

NIK SMI1

(R)-6-(3-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide

2-Pyridinecarboxamide, 6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxo-3-pyrrolidinyl]ethynyl]phenyl]-4-methoxy-

NIK inhibitor 4f(NIK SMI1)

NIK SMI1,Nuclear factor-κB,NIK SMI 1,Nuclear factor-kappaB,inhibit,Inhibitor,NF-κB,NIK SMI-1

4-methoxy-6-(3-methylphenyl)pyridine-2-carboxamide

NIK SMI1, 10 mM in DMSO

1660114-31-7