ChemicalBook > CAS DataBase List > NIK SMI1
NIK SMI1
- Product Name
- NIK SMI1
- CAS No.
- 1660114-31-7
- Chemical Name
- NIK SMI1
- Synonyms
- NIK SMI1;NIK SMI1, 10 mM in DMSO;NIK inhibitor 4f(NIK SMI1);4-methoxy-6-(3-methylphenyl)pyridine-2-carboxamide;(R)-6-(3-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide;NIK SMI1,Nuclear factor-κB,NIK SMI 1,Nuclear factor-kappaB,inhibit,Inhibitor,NF-κB,NIK SMI-1;2-Pyridinecarboxamide, 6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxo-3-pyrrolidinyl]ethynyl]phenyl]-4-methoxy-
- CBNumber
- CB25419793
- Molecular Formula
- C20H19N3O4
- Formula Weight
- 365.38
- MOL File
- 1660114-31-7.mol
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NIK SMI1 Property
- Boiling point:
- 626.7±55.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (273.69 mM)
- form
- Solid
- pka
- 11.14±0.20(Predicted)
- color
- Off-white to pink
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML3129
- Product name
- NIK SMI1
- Purity
- ≥95% (HPLC)
- Packaging
- 5MG
- Price
- $240
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML3129
- Product name
- NIK SMI1
- Purity
- ≥95% (HPLC)
- Packaging
- 25MG
- Price
- $770
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-0046051
- Product name
- NIKSMI1
- Purity
- 99.01%
- Packaging
- 10mg
- Price
- $850
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0046051
- Product name
- NIKSMI1
- Purity
- 99.01%
- Packaging
- 50mg
- Price
- $2650
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC10927
- Product name
- NIKinhibitor4f(NIKSMI1)
- Purity
- >98%
- Packaging
- 250mg
- Price
- $2000
- Updated
- 2021/12/16
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NIK SMI1 Chemical Properties,Usage,Production
Uses
NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor.
Biological Activity
NIK SMI1 is an orally active, ATP site-targeting, potent and selective NF-KB-inducing kinase inhibitor (h/m NIK IC50 = 230/395 pM; hKHS1/hPKD1/hLRRK2 = 49.6/75.2/247.8 nM) th at selectively disrupts noncanonical NF-KB signaling (anti-LTβR-induced p52 nuclear translocation IC50 = 70 nM; TNFα-induced p65 RelA nuclear translocation IC50 >2 μM). SMI1 inhibits BAFF receptor- and CD40-mediated singling in cultures (human and murine B-cells) and shows in vivo efficacy in the NZB/W F1 murine experimental lupus model (6-400 mg/kg/day, b.i.d. p.o.).
NIK SMI1 Preparation Products And Raw materials
Raw materials
Preparation Products
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