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Sodium taurodeoxycholate hydrate

Product Name
Sodium taurodeoxycholate hydrate
CAS No.
207737-97-1
Chemical Name
Sodium taurodeoxycholate hydrate
Synonyms
5β12αsodium 2-[[(3αSodium taurodeoxycholate, ≥99%;SODIUM TAURODEOXYCHOLATE HYDRATE;N-(Deoxycholyl)taurine sodium salt;SODIUM TAURODEOXYCHOLATE HYDRATE BIO;Taurodeoxycholic acid sodium hydrate;Taurodeoxycholic Acid-[d6] Sodium Salt;2H6]-Taurodeoxycholic Acid Sodium Salt
CBNumber
CB2547459
Molecular Formula
C26H48NNaO7S
Formula Weight
541.72
MOL File
207737-97-1.mol
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Sodium taurodeoxycholate hydrate Property

Melting point:
168 °C (dec.)(lit.)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: soluble0.5M, clear, colorless to faintly yellow
form 
A crystalline solid
color 
White to off-white
BRN 
3901204
InChIKey
GFBBTUJLLSJWQW-RIIXSHNENA-N
SMILES
C[C@]12[C@H](C[C@]3([H])[C@]4(CC[C@@H](O)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@]2([H])[C@H](C)CCC(=O)NCCS(O)(=O)=O)C)O.[NaH].O |&1:1,2,4,6,9,12,16,18,22,24,r|
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Safety

WGK Germany 
3
HS Code 
29242998
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T0557
Product name
Sodium taurodeoxycholate hydrate
Purity
BioXtra, ≥97% (TLC)
Packaging
1g
Price
$84.7
Updated
2024/03/01
Sigma-Aldrich
Product number
T0557
Product name
Sodium taurodeoxycholate hydrate
Purity
BioXtra, ≥97% (TLC)
Packaging
5g
Price
$247
Updated
2024/03/01
Cayman Chemical
Product number
15935
Product name
Taurodeoxycholic Acid (sodium salt hydrate)
Purity
≥95%
Packaging
1g
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
15935
Product name
Taurodeoxycholic Acid (sodium salt hydrate)
Purity
≥95%
Packaging
5G
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
15935
Product name
Taurodeoxycholic Acid (sodium salt hydrate)
Purity
≥95%
Packaging
25g
Price
$426
Updated
2024/03/01
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Sodium taurodeoxycholate hydrate Chemical Properties,Usage,Production

Description

Sodium taurodeoxycholate hydrate is a bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. It has also been used in a study to investigate polymorphic behavior in protein surfactant mixtures.
Sodium taurodeoxycholate hydrate has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane. It has also been used in a study to investigate polymorphic behavior in protein-surfactant mixtures.

Uses

A hydrate form of sodium taurodeoxycholate (T009005), a steroid which rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.

General Description

Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.

Purification Methods

The Na salt is dissolved in the smallest volume of H2O, a saturated solution of aqueous NaCl/Et2O is added and the mixture is stored at 0o for 24hours. Then shake the mixture well, keep it in the cold for another day and filter the crystals with gentle shaking, wash them with ice-cold saturated aqueous NaCl saturated with Et2O, dry them over CaCl2 and extract them with absolute EtOH. Add ~10mL of H2O to the solid followed by enough Et2O to incipient cloudiness. Store it overnight at 0o. Add ice-cold Et2O to make 250mL, collect the crystals, wash them with Et2O then pet ether and dry them in air. The purification can be repeated with NaCl and Et2O with ~85% recovery. NB: precipitation will not occur unless enough H2O is present. Its solubility in H2O is 10%. [Cortese J Am Chem Soc 59 2532 1937.] The free acid has m 141-144o. [Norman Ark Kemi 8 331 1956.] It forms mixed micelles and solubilises some membrane proteins [Hajjar et al. J Biol Chem 2 5 8 192 1983]. [Beilstein 10 IV 1611.]

Mode of action

Sodium taurodeoxycholate hydrate functions as a surfactant in experimental applications. It reduces the surface tension of liquids, allowing for improved solubility and dispersion of substances in aqueous solutions. Sodium Taurodeoxycholate Hydrate interacts with lipid molecules, disrupting their organization and facilitating the emulsification of fats. Sodium taurodeoxycholate hydrate also plays a role in cell membrane permeabilization, aiding in the uptake of hydrophobic compounds by cells. At the molecular level, Sodium taurodeoxycholate hydrate interacts with cholesterol and phospholipids, influencing their arrangement and fluidity within lipid bilayers. It can form micelles, which assist in solubilising poorly water-soluble substances for experimental purposes.

Sodium taurodeoxycholate hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Sodium taurodeoxycholate hydrate Suppliers

Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
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China
ProdList
11578
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Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
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China
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2208
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
Fax
86-10-82849933
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jkinfo@jkchemical.com
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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021-61259108 18621169109
Fax
86-21-61259102
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market03@meryer.com
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China
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40228
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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Shandong Xiya Chemical Co., Ltd
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4009903999 13355009207
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0539-6365991
Email
3007715519@qq.com
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China
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18738
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Tianjin heowns Biochemical Technology Co., Ltd.
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400 638 7771
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sales@heowns.com
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China
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14435
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Sinopharm Chemical Reagent Co,Ltd.
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86-21-63210123
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86-21-63290778 86-21-63218885
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sj_scrc@sinopharm.com
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China
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Hunan Hui Bai Shi Biotechnology Co., Ltd.
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0731-85526065 13308475853
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ivy@hnhbsj.com
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China
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Thermo Fisher Scientific
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800-810-5118
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+86-10-84193589
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cnchemical@thermofisher.com
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China
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View Lastest Price from Sodium taurodeoxycholate hydrate manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
Sodium taurodeoxycholate 207737-97-1
Price
US $499.00-399.00/kg
Min. Order
0.1kg
Purity
99%min
Supply Ability
1ton
Release date
2024-11-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Sodium taurodeoxycholate hydrate 207737-97-1
Price
US $0.00/G
Min. Order
500G
Purity
97%min
Supply Ability
30kg/month
Release date
2023-02-02
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Taurodeoxycholic Acid Sodium Salt 207737-97-1
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-09-29

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