Taurodeoxycholic acid sodium salt
- Product Name
- Taurodeoxycholic acid sodium salt
- CAS No.
- 1180-95-6
- Chemical Name
- Taurodeoxycholic acid sodium salt
- Synonyms
- SODIUM TAURODEOXYCHOLATE;Taurodeoxycholate sodium salt;Taurodeoxycholic acid sodium salt hydrate;5B2;12B1;sodium 2-[[(3B1;sodium taurodeoxylate;SodiuM taurodeoxycholat;Sodium deoxytaurocholate;Taurodeoxycholate sodium
- CBNumber
- CB9349065
- Molecular Formula
- C26H44NNaO6S
- Formula Weight
- 521.69
- MOL File
- 1180-95-6.mol
Taurodeoxycholic acid sodium salt Property
- Melting point:
- 168 °C (dec.)(lit.)
- alpha
- 33 º (c=3, water)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- H2O: 0.5 M at 20 °C, clear, colorless to faintly yellow
- form
- Solid
- pka
- 1.9
- color
- White to Off-White
- Water Solubility
- soluble
- InChIKey
- YXHRQQJFKOHLAP-UROAIUCXNA-M
- CAS DataBase Reference
- 1180-95-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 580221
- Product name
- Taurodeoxycholic Acid, Sodium Salt - CAS 1180-95-6 - Calbiochem
- Purity
- Detergentusefulforthesolubilizationoflipidsandmembrane-boundproteins.A
- Packaging
- 5G
- Price
- $182
- Updated
- 2024/03/01
- Product number
- 580221
- Product name
- Taurodeoxycholic Acid, Sodium Salt - CAS 1180-95-6 - Calbiochem
- Purity
- Detergentusefulforthesolubilizationoflipidsandmembrane-boundproteins.A
- Packaging
- 50g
- Price
- $745
- Updated
- 2024/03/01
- Product number
- 15935
- Product name
- Taurodeoxycholic Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 15935
- Product name
- Taurodeoxycholic Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 15935
- Product name
- Taurodeoxycholic Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 25g
- Price
- $350
- Updated
- 2021/12/16
Taurodeoxycholic acid sodium salt Chemical Properties,Usage,Production
Chemical Properties
white to almost white crystalline powder
Uses
Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.
in vivo
Taurodeoxycholate (1.25-5 mg/kg, p.o., 6 days) sodium salt ameliorates dextran sodium sulfate (DSS)-induced colitis in mice[9].
Taurodeoxycholate sodium salt (Taurodeoxycholic acid form, 50 mg/kg; i.p.; once daliy for 34 d) prevents neuropathology and associated behavioral deficits in the 3-nitropropionic acid rat model of Huntington's disease (HD) [10].
Taurodeoxycholate sodium salt (Taurodeoxycholic acid form, 500 mg/kg; s.c.; once every 3 d for 7 weeks) leads to a significant reduction in striatal neuropathology of the R6/2 transgenic HD mouse[11].
Taurodeoxycholate (0.5 mg/kg; i.v., once) sodium salt confers protection to C57BL/6N mice with sepsis, but does not protect TGR5 KO mice under sepsis[12].
| Animal Model: | A mouse colitis model (fed with 3% (w/v) DSS in drinking water for the first seven days and then switched to normal drinking water for an additional two days)[9] |
| Dosage: | 1.25, 2.5, and 5 mg/kg |
| Administration: | Oral gavage (p.o.), from day 3 to day 8, once a day |
| Result: | Prevented loss of body weight, shortening of the colon, production of pro-inflammatory cytokines, infiltration of pro-inflammatory cells, and mucosal ulceration in the colon. |
| Animal Model: | Huntington's disease model in mouse[10] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment |
| Result: | Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions. Significantly improved locomotor and sensorimotor deficits. |
| Animal Model: | C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis[12] |
| Dosage: | 0.5 mg/kg |
| Administration: | Intravenous injection, 30 min or 24 h after LPS injection |
| Result: | Improved the survival rate of mice with sepsis. Decreased liver and kidney damage in septic mice. Ameliorated systemic inflammation and normalized blood pressure in septic mice. |
Purification Methods
The Na salt is dissolved in the smallest volume of H2O, a saturated solution of aqueous NaCl/Et2O is added and the mixture is stored at 0o for 24hours. Then shake the mixture well, keep it in the cold for another day and filter the crystals with gentle shaking, wash them with ice-cold saturated aqueous NaCl saturated with Et2O, dry them over CaCl2 and extract them with absolute EtOH. Add ~10mL of H2O to the solid followed by enough Et2O to incipient cloudiness. Store it overnight at 0o. Add ice-cold Et2O to make 250mL, collect the crystals, wash them with Et2O then pet ether and dry them in air. The purification can be repeated with NaCl and Et2O with ~85% recovery. NB: precipitation will not occur unless enough H2O is present. Its solubility in H2O is 10%. [Cortese J Am Chem Soc 59 2532 1937.] The free acid has m 141-144o. [Norman Ark Kemi 8 331 1956.] It forms mixed micelles and solubilises some membrane proteins [Hajjar et al. J Biol Chem 2 5 8 192 1983]. [Beilstein 10 IV 1611.]
Taurodeoxycholic acid sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
Taurodeoxycholic acid sodium salt Suppliers
- Tel
- 025-58862853 18915922038
- Fax
- +86-025-58862853
- sales@endesachem.com
- Country
- China
- ProdList
- 591
- Advantage
- 58
- Tel
- 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44732
- Advantage
- 61
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 4000
- Advantage
- 55
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4729
- Advantage
- 58
View Lastest Price from Taurodeoxycholic acid sodium salt manufacturers
- Product
- Sodium taurodeoxycholate 1180-95-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 1000KG
- Release date
- 2025-04-22
- Product
- Taurodeoxycholic acid sodium salt 1180-95-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04
- Product
- Taurodeoxycholic acid 1180-95-6
- Price
- US $120.00/KG
- Min. Order
- 1KG
- Purity
- 99.99%
- Supply Ability
- 100KG
- Release date
- 2025-02-25