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Sodium deoxycholate

Product Name
Sodium deoxycholate
CAS No.
302-95-4
Chemical Name
Sodium deoxycholate
Synonyms
SODIUM CHOLEATE;DEOXYCHOLIC ACID SODIUM SALT;SODIUM DESOXYCHOLATE;NSC 681065;sodium 3-B1;OXIDE EXTRACT;na-desoxycholat;Sodium deoxychoL;-dihydroxy-5-B2;deoxycholatesodium
CBNumber
CB4452346
Molecular Formula
C24H41NaO4
Formula Weight
416.58
MOL File
302-95-4.mol
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Sodium deoxycholate Property

Melting point:
357-365 °C
alpha 
44 º (c=2, H2O)
Density 
1.012 at 20.07℃
vapor pressure 
0Pa at 20℃
Flash point:
>110°C (own results)
storage temp. 
room temp
solubility 
water: soluble1 gm in 10 ml, clear, colorless to very faintly yellow
form 
Powder
color 
Yellow-tan
PH
7.5-9.0 (20g/l, H2O, 20℃)
Odor
Odorless
PH Range
7 - 10
optical activity
[α]20/D +44±2°, c = 2% in H2O
Water Solubility 
330 g/L (15 ºC)
BRN 
3581950
LogP
5.35 at 22℃ and pH5.7
Surface tension
41.8mN/m at 1g/L and 20℃
CAS DataBase Reference
302-95-4(CAS DataBase Reference)
EPA Substance Registry System
Cholan-24-oic acid, 3,12-dihydroxy-, monosodium salt, (3.alpha.,5.beta.,12.alpha.)- (302-95-4)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
FZ2250000
3-10
TSCA 
Yes
HS Code 
29181930
Toxicity
LD50 orally in Rabbit: 1370 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
30970
Product name
Sodium deoxycholate
Purity
anionic
Packaging
25g
Price
$59.9
Updated
2024/03/01
Sigma-Aldrich
Product number
30970
Product name
Sodium deoxycholate
Purity
anionic
Packaging
100g
Price
$163
Updated
2024/03/01
Sigma-Aldrich
Product number
264103
Product name
Deoxycholic Acid, Sodium Salt, ULTROL® Grade
Purity
Highly purified and intended for use as a detergent to solubilize membrane-bound proteins in their native state.
Packaging
5G
Price
$177
Updated
2024/03/01
Sigma-Aldrich
Product number
264101
Product name
Deoxycholic Acid sodium
Purity
An ionic detergent for the solubilization of membrane-bound proteins.
Packaging
25g
Price
$86.5
Updated
2024/03/01
Sigma-Aldrich
Product number
264103
Product name
Deoxycholic Acid, Sodium Salt, ULTROL® Grade
Purity
Highly purified and intended for use as a detergent to solubilize membrane-bound proteins in their native state.
Packaging
25G
Price
$646
Updated
2024/03/01
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Sodium deoxycholate Chemical Properties,Usage,Production

Chemical Properties

Sodium deoxycholate is white to cream crystalline powder

Uses

Sodium deoxycholate is an ionic detergent for the solubilization of membrane-bound proteins.

Uses

Sodium deoxycholate is used as a choleretic and an anionic detergent. It is useful for the extraction of membrane receptors, plasma membrane proteins, nuclei isolation and solubilizes fats as well as membrane components. It acts as an intermediate for the production of corticosteroids and microbiological diagnostic media. In addition, it acts as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Uses

Sodium deoxycholate is used as a component in cell lysis buffers.

Definition

ChEBI: Sodium deoxycholate is a bile acid salt. It contains a deoxycholate.

General Description

Sodium deoxycholate is a bile salt and an ionic detergent. Bile salts work along with lipids/fats/cholesterol and form mixed micelles in the intestine. These micelles help in fat digestion and absorption through the intestinal wall.

Biological Activity

Sodium deoxycholate (SDC) is an anionic detergent which has been used both to destroy infectious viruses and to fractionate viral components. Sodium deoxycholate begins to bind to the virus at less than 0.1 mM free equilibrium concentration. It causes lysis of the viral membrane at 0.9 +/- 0.1 mM free equilibrium concentration when 2.2 +/- 0.2 - 103 mol of sodium deoxycholate are bound per mol of the virus. The liberation of proteins from the membrane begins at 1.5 +/- 0.1 mM sodium deoxycholate, and the proteins released are virtually free from phospholipids above 2.0 mM sodium deoxycholate. The overall mechanism of sodium deoxycholate solubilization of the viral membrane resembles that of Triton X-100 and sodium dodecyl sulphate, except that with sodium deoxycholate, the various stages of membrane disruption occur at about 10-fold higher equilibrium free detergent concentrations. At sodium deoxycholate concentrations higher than 2.3 mM, the viral spike glycoproteins can be separated by sucrose gradient centrifugation or gel filtration into constituent polypeptides E1, E2 and E3[1-2].

Biochem/physiol Actions

Solubilizes fats for absorption in the intestines.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NasO.

Purification Methods

Recrystallise it from EtOH and dry it in an oven at 100o. The solution is freed from soluble components by repeated extraction with acid-washed charcoal. [Beilstein 10 IV 1608.]

References

[1] A Helenius. “Solubilization of the Semliki Forest virus membrane with sodium deoxycholate.” Biochimica et biophysica acta 436 2 (1976): 319–34.
[2] A E Auletta, M L Marlowe. “Effect of sodium deoxycholate on rubella virus.” Applied microbiology 16 10 (1968): 1624.

Sodium deoxycholate Preparation Products And Raw materials

Raw materials

Preparation Products

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Sodium deoxycholate Suppliers

Chengdu Chenlv Herb Co., Ltd.
Tel
028-88523492 15528171243
Email
chenrongpharma@126.com
Country
China
ProdList
124
Advantage
58
Wuhu Nuowei Chemical Technology Co., Ltd
Tel
0553-2911116 18055326116
Email
sales@nuowei-chem.com
Country
China
ProdList
309
Advantage
58
Wuhan Huajiu Pharmaceutical Technology Co.,Ltd.
Tel
027-59225746 18062681621
Fax
027-59225746
Email
730880265@qq.com
Country
China
ProdList
4785
Advantage
58
Kono Chem Co., Ltd
Tel
029-86107037-8014 18292830413
Email
info@konochemical.com
Country
China
ProdList
537
Advantage
58
Shaanxi Pioneer Biotech Co.,Ltd
Tel
18629309720 18629309720
Email
sales@pioneerbiotech.com
Country
China
ProdList
328
Advantage
58
Shaanxi Pioneer Biotech Co., Ltd.
Tel
13720616393;029-84385017-8003 13720616393
Fax
029-84385017
Email
sales@pioneerbiotech.com
Country
China
ProdList
1063
Advantage
56
Henan Evonik Biotechnology Co. LTD
Tel
16650615803
Email
hnyingchuang@163.com
Country
China
ProdList
3926
Advantage
58
Hubei Hengluyuan Technology co.ltd
Tel
027-88188016 18717196322
Email
1764683941@qq.com
Country
China
ProdList
5748
Advantage
58
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2045
Advantage
56
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
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View Lastest Price from Sodium deoxycholate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Sodium deoxycholate 302-95-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%min
Supply Ability
100KGS
Release date
2024-09-03
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Sodium deoxycholate 302-95-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-08
Hebei Weibang Biotechnology Co., Ltd
Product
Sodium deoxycholate 302-95-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06

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