Sodium taurodeoxycholate hydrate
- Product Name
- Sodium taurodeoxycholate hydrate
- CAS No.
- 207737-97-1
- Chemical Name
- Sodium taurodeoxycholate hydrate
- Synonyms
- 5β12αsodium 2-[[(3αSodium taurodeoxycholate, ≥99%;SODIUM TAURODEOXYCHOLATE HYDRATE;N-(Deoxycholyl)taurine sodium salt;SODIUM TAURODEOXYCHOLATE HYDRATE BIO;Taurodeoxycholic acid sodium hydrate;Taurodeoxycholic Acid-[d6] Sodium Salt;2H6]-Taurodeoxycholic Acid Sodium Salt
- CBNumber
- CB2547459
- Molecular Formula
- C26H48NNaO7S
- Formula Weight
- 541.72
- MOL File
- 207737-97-1.mol
Sodium taurodeoxycholate hydrate Property
- Melting point:
- 168 °C (dec.)(lit.)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- H2O: soluble0.5M, clear, colorless to faintly yellow
- form
- A crystalline solid
- color
- White to off-white
- BRN
- 3901204
Safety
- WGK Germany
- 3
- HS Code
- 29242998
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- T0557
- Product name
- Sodium taurodeoxycholate hydrate
- Purity
- BioXtra, ≥97% (TLC)
- Packaging
- 1g
- Price
- $84.7
- Updated
- 2024/03/01
- Product number
- T0557
- Product name
- Sodium taurodeoxycholate hydrate
- Purity
- BioXtra, ≥97% (TLC)
- Packaging
- 5g
- Price
- $247
- Updated
- 2024/03/01
- Product number
- 15935
- Product name
- Taurodeoxycholic Acid (sodium salt hydrate)
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 15935
- Product name
- Taurodeoxycholic Acid (sodium salt hydrate)
- Purity
- ≥95%
- Packaging
- 5G
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 15935
- Product name
- Taurodeoxycholic Acid (sodium salt hydrate)
- Purity
- ≥95%
- Packaging
- 25g
- Price
- $426
- Updated
- 2024/03/01
Sodium taurodeoxycholate hydrate Chemical Properties,Usage,Production
Description
Sodium taurodeoxycholate hydrate is a bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. It has also been used in a study to investigate polymorphic behavior in protein surfactant mixtures.
Sodium taurodeoxycholate hydrate has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane. It has also been used in a study to investigate polymorphic behavior in protein-surfactant mixtures.
Uses
A hydrate form of sodium taurodeoxycholate (T009005), a steroid which rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.
General Description
Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.
Purification Methods
The Na salt is dissolved in the smallest volume of H2O, a saturated solution of aqueous NaCl/Et2O is added and the mixture is stored at 0o for 24hours. Then shake the mixture well, keep it in the cold for another day and filter the crystals with gentle shaking, wash them with ice-cold saturated aqueous NaCl saturated with Et2O, dry them over CaCl2 and extract them with absolute EtOH. Add ~10mL of H2O to the solid followed by enough Et2O to incipient cloudiness. Store it overnight at 0o. Add ice-cold Et2O to make 250mL, collect the crystals, wash them with Et2O then pet ether and dry them in air. The purification can be repeated with NaCl and Et2O with ~85% recovery. NB: precipitation will not occur unless enough H2O is present. Its solubility in H2O is 10%. [Cortese J Am Chem Soc 59 2532 1937.] The free acid has m 141-144o. [Norman Ark Kemi 8 331 1956.] It forms mixed micelles and solubilises some membrane proteins [Hajjar et al. J Biol Chem 2 5 8 192 1983]. [Beilstein 10 IV 1611.]
Sodium taurodeoxycholate hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Sodium taurodeoxycholate hydrate manufacturers
- Product
- Sodium taurodeoxycholate 207737-97-1
- Price
- US $499.00-399.00/kg
- Min. Order
- 0.1kg
- Purity
- 99%min
- Supply Ability
- 1ton
- Release date
- 2024-11-25
- Product
- Sodium taurodeoxycholate hydrate 207737-97-1
- Price
- US $0.00/G
- Min. Order
- 500G
- Purity
- 97%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-02
- Product
- Taurodeoxycholic Acid Sodium Salt 207737-97-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-09-29