BI-3406
- Product Name
- BI-3406
- CAS No.
- 2230836-55-0
- Chemical Name
- BI-3406
- Synonyms
- N-((R)-1-(3-Amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-amine;BI-3406;SOS1-IN-2;BI-3406 ，S8916;BI-3406(SOS1-IN-2);N-[(1R)-1-[3-Amino-5-;BI-3406, 10 mM in DMSO;N-[(1R)-1-[3-Amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine;KRAS,interaction,anticancer,Inhibitor,BI3406,BI 3406,inhibit,Son,Sevenless,GTP-loaded,BI-3406,Ras,p38 MAPK,orally,SOS1;N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-4-amine
- CBNumber
- CB25559774
- Molecular Formula
- C23H25F3N4O3
- Formula Weight
- 462.46
- MOL File
- 2230836-55-0.mol
BI-3406 Property
- Boiling point:
- 534.5±50.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);216.23(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);216.23(Max Conc. mM) - form
- A solid
- pka
- 6.58±0.70(Predicted)
- color
- White to off-white
- InChIKey
- XVFDNRYZXDHTHT-PXAZEXFGSA-N
- SMILES
- N1=C2C(C=C(O[C@H]3CCOC3)C(OC)=C2)=C(N[C@@H](C2=CC(C(F)(F)F)=CC(N)=C2)C)N=C1C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CS-0100048
- Product name
- BI-3406
- Purity
- 99.79%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0100048
- Product name
- BI-3406
- Purity
- 99.79%
- Packaging
- 10mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- CS-0100048
- Product name
- BI-3406
- Purity
- 99.79%
- Packaging
- 50mg
- Price
- $2000
- Updated
- 2021/12/16
- Product number
- CS-0100048
- Product name
- BI-3406
- Purity
- 99.79%
- Packaging
- 100mg
- Price
- $3500
- Updated
- 2021/12/16
- Product number
- DC39083
- Product name
- BI-3406
- Packaging
- 100mg
- Price
- $900
- Updated
- 2021/12/16
BI-3406 Chemical Properties,Usage,Production
Uses
BI-3406 (compound I-6) is an orally active, highly potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. BI-3406 potently reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 has anticancer activity[1][2].
IC 50
KRAS-SOS1: 6 nM (IC50)
References
[1] Michael Gmachl, et al. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors. WO2018115380A1.
[2] Marco H Hofmann, et al. Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors. December 2019.
BI-3406 Preparation Products And Raw materials
Raw materials
Preparation Products
BI-3406 Suppliers
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