CYFIP1 antibody
Source Reactivity Background References- Product Name
- CYFIP1 antibody
- Chemical Name
- CYFIP1 antibody
- Synonyms
- CYFIP1 antibody
- CBNumber
- CB25620847
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb182832
- Product name
- CYFIP1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb182832
- Product name
- CYFIP1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
CYFIP1 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse
Background
Cytoplasmic FMR1-interacting protein 1 is a component of the CYFIP1/EIF4E/FMR1 complex which mediates translational repression by binding to the mRNA cap. CYFIP1 also plays a role in neuronal axonal growth dynamics by binding to the WAVE complex to regulate remodeling of actin filaments. Mutations in the gene encoding CYFIP1 has been linked to multiple neural development and psychiatric disorders, including autism spectrum disorder and schizophrenia. The specific mechanism by which CYFIP1, which is enriched in synapses, contributes to these neurological diseases is unknown, but may involve regulating the balance of synaptic excitation and inhibition to maintain neuronal circuit homeostasis during development and in mature brains.
References
[1] Napoli, I. et al. (2008) Cell 134, 1042-54.
[2] Chen, Z. et al. (2010) Nature 468, 533-8.
[3] Toma, C. et al. (2014) Mol Psychiatry 19, 784-90.
[4] Wang, J. et al. (2015) Ann Hum Genet 79, 329-40.
[5] Tam, G.W. et al. (2010) Biochem Soc Trans 38, 445-51.
[6] Yoon, K.J. et al. (2014) Cell Stem Cell 15, 79-91.
[7] Davenport, E.C. et al. (2019) Cell Rep 26, 2037-51.e6.
CYFIP1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
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