DIDO1 Antibody
Source Reactivity Background References- Product Name
- DIDO1 Antibody
- Chemical Name
- DIDO1 Antibody
- Synonyms
- DIDO1 Antibody
- CBNumber
- CB25622371
- Formula Weight
- 0
- MOL File
- Mol file
DIDO1 Antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat
Background
The putative transcription factor DIDO1 contains a pair of zinc finger motifs and is upregulated by apoptotic stimuli. DIDO1 is expressed in the developing limb and may play a role in controlling programmed cell death during development. Nuclear translocation of DIDO1 during apoptosis is associated with its apoptotic activity. Alternative splicing produces the DIDO-1, -2 and -3 isoforms, whose targeted disruption in mice produces a phenotype similar to myelodysplastic/myeloproliferative disease in humans. DIDO3, the largest of the splice variants, is associated with the centrosome and plays a role in mitotic checkpoint and chromosome stability.
References
[1] García-Domingo, D. et al. (1999) Proc Natl Acad Sci U S A 96, 7992-7.
[2] Gomes, I. et al. (2002) Blood 100, 107-19.
[3] Fütterer, A. et al. (2005) J Clin Invest 115, 2351-62.
[4] Trachana, V. et al. (2007) Proc Natl Acad Sci U S A 104, 2691-6.
DIDO1 Antibody Preparation Products And Raw materials
Raw materials
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