IMPDH1 antibody
Source Reactivity Background References- Product Name
- IMPDH1 antibody
- Chemical Name
- IMPDH1 antibody
- Synonyms
- IMPDH1 antibody
- CBNumber
- CB25647312
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb101305
- Product name
- IMPDH1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb101305
- Product name
- IMPDH1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
IMPDH1 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
Inosine-5'-monophosphate dehydrogenase catalyzes the conversion of IMP to XMP, the first and rate-limiting step of guanine nucleotide biosynthesis. The isozymes IMPDH1 and IMPDH2 are encoded by two distinct genes. Research studies show that IMPDH2 is overexpressed in glioblastoma. In glioblastoma, IMPDH2-mediated GTP biosynthesis is essential for rRNA and tRNA synthesis and the formation of enlarged and irregular nucleoli. In addition, IMPDH1 and IMPDH2 double knockout leads to significant inhibition of tumor growth in an orthotopic glioblastoma model. Furthermore, IMPDH1 and IMPDH2 expression is upregulated in small cell lung cancer cells with low expression of ASCL1 transcription factor. Suppression of IMPDH activity inhibits ASCL1Low small cell lung cancer growth.
References
[1] Lin, R. et al. (2017) Mol Cell 68, 198-209.e6.
[2] Liao, L.X. et al. (2017) Proc Natl Acad Sci U S A 114, E5986-E5994.
[3] Kofuji, S. et al. (2019) Nat Cell Biol 21, 1003-14.
[4] Huang, F. et al. (2018) Cell Metab 28, 369-382.e5.
IMPDH1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
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