PSMA3 antibody
Source Reactivity Background References- Product Name
- PSMA3 antibody
- Chemical Name
- PSMA3 antibody
- Synonyms
- PSMA3 antibody;Rabbit Polyclonal PSMA3 Antibody
- CBNumber
- CB25676804
- Formula Weight
- 0
- MOL File
- Mol file
PSMA3 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. It consists of four stacked rings, each with seven distinct subunits. The two outer layers are identical rings composed of α subunits, and the two inner layers are identical rings composed of β subunits. While the catalytic sites are located on the β rings, the α subunits are important for assembly and as binding sites for regulatory proteins. Seven different α and ten different β proteasome genes have been identified in mammals. PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. PA700 binds polyubiquitin with high affinity and associates with the 20S proteasome to form the 26S proteasome, which preferentially degrades polyubiquitinated proteins. The proteasome has a broad substrate spectrum that includes cell cycle regulators, signaling molecules, tumor suppressors, and transcription factors. By controlling the degradation of these intracellular proteins, the proteasome functions in cell cycle regulation, cancer development, immune responses, protein folding, and disease progression.
References
[1] Dahlmann, B. (2005) Essays Biochem. 41, 31-48.
[2] Pickart, C.M. and Cohen, R.E. (2004) Nat. Rev. Mol. Cell Biol. 5, 177-87.
[3] Nandi, D. et al. (2006) J. Biosci. 31, 137-55.
[4] Lupas, A. et al. (1993) Enzyme Protein 47, 252-73.
[5] Monaco, J.J. and Nandi, D. (1995) Annu. Rev. Genet. 29, 729-54.
[6] Murray, A.W. (2004) Cell 116, 221-34.
[7] Ciechanover, A. (2006) Proc. Am. Thorac. Soc. 3, 21-31.
[8] Wang, J. and Maldonado, M.A. (2006) Cell. Mol. Immunol. 3, 255-61.
[9] Rubinsztein, D.C. (2006) Nature 443, 780-6.
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