SIRT4 antibody
Source Reactivity Background References- Product Name
- SIRT4 antibody
- Chemical Name
- SIRT4 antibody
- Synonyms
- SIRT4 antibody;Mouse Monoclonal SIRT4 Antibody
- CBNumber
- CB25696022
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb101356
- Product name
- SIRT4 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $402.9
- Updated
- 2021/12/16
- Product number
- orb155291
- Product name
- SIRT4 antibody
- Purity
- Antigen Affinity Purified
- Packaging
- 100μg
- Price
- $425
- Updated
- 2021/12/16
- Product number
- orb18632
- Product name
- SIRT4 antibody
- Purity
- Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
- Packaging
- 100μg
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- orb165264
- Product name
- SIRT4 antibody
- Purity
- Peptide Affinity purified
- Packaging
- 400μl
- Price
- $525.3
- Updated
- 2021/12/16
- Product number
- orb75430
- Product name
- SIRT4 antibody
- Packaging
- 100μL
- Price
- $584.8
- Updated
- 2021/12/16
SIRT4 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
The Silent Information Regulator family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide-dependent protein deacetylases, initially classified as Class III histone deacetylases. The first discovered and best characterized of these genes is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT4, a mammalian homolog of Sir2, is localized to the mitochondria and has been implicated in the regulation of cell metabolism, oxidative stress, genomic stability, and aging. In addition to deacetylase activity, multiple additional enzymatic activities have been attributed to SirT4, including protein deacylation, ADP-ribosylation, and NAD-dependent protein lipoamidase activity. SirT4 regulates the metabolism of glutamine, lipids, and glucose through direct deacetylation of malonyl CoA decarboxylase, ADP-ribosylation of glutamine dehydrogenase, and hydrolysis of the lipoamide cofactors from the E2 component dihydrolipoyllysine acetyltransferase of the pyruvate dehydrogenase complex. SirT4 is a tumor suppressor protein, and expression is reduced or lost in a large number of cancers, resulting in the acceleration of tumor morbidity and metastasis.
References
[1] Guarente, L. (1999) Nat Genet 23, 281-5.
[2] Bai, Y. et al. (2020) Front Oncol 10, 562950.
[3] Wang, C. et al. (2020) Oncol Lett 20, 11.
[4] Laurent, G. et al. (2013) Mol Cell 50, 686-98.
[5] Haigis, M.C. et al. (2006) Cell 126, 941-54.
[6] Mathias, R.A. et al. (2014) Cell 159, 1615-25.
SIRT4 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
SIRT4 antibody Suppliers
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