PNU-282987 S enantiomer hydrochloride
- Product Name
- PNU-282987 S enantiomer hydrochloride
- CAS No.
- 128311-08-0
- Chemical Name
- PNU-282987 S enantiomer hydrochloride
- Synonyms
- (S)-PNU-282987 HCl;(S)-PNU-282987 hydrochloride;PNU-282987 S enantiomer hydrochloride;(S)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride;PNU282987 S enantiomer hydrochloride,PNU 282987 S enantiomer hydrochloride
- CBNumber
- CB25830974
- Molecular Formula
- C14H18Cl2N2O
- Formula Weight
- 301.21
- MOL File
- 128311-08-0.mol
PNU-282987 S enantiomer hydrochloride Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A1219190
- Product name
- (S)-4-Chloro-N-(quinuclidin-3-yl)benzamidehydrochloride
- Purity
- 98%
- Packaging
- 5mg
- Price
- $248
- Updated
- 2021/12/16
- Product number
- CSN25275
- Product name
- (S)-PNU-282987HCl
- Packaging
- 5mg
- Price
- $278
- Updated
- 2021/12/16
- Product number
- A1219190
- Product name
- (S)-4-Chloro-N-(quinuclidin-3-yl)benzamidehydrochloride
- Purity
- 98%
- Packaging
- 10mg
- Price
- $348
- Updated
- 2021/12/16
- Product number
- A1219190
- Product name
- (S)-4-Chloro-N-(quinuclidin-3-yl)benzamidehydrochloride
- Purity
- 98%
- Packaging
- 25mg
- Price
- $594
- Updated
- 2021/12/16
PNU-282987 S enantiomer hydrochloride Chemical Properties,Usage,Production
Uses
(S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].
in vivo
PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner[1].
References
[1] Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8. DOI:10.1021/jm049363q
PNU-282987 S enantiomer hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
PNU-282987 S enantiomer hydrochloride Suppliers
- Tel
- 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15873
- Advantage
- 55
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 8011
- Advantage
- 55
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- 15865264761
- 486064515@qq.com
- Country
- China
- ProdList
- 4810
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50751
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58