N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE

Product Name: N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE
CAS No.: 123464-89-1
Chemical Name: N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE
Synonyms: SKL843;CS-1012;PNU 282987;PNU282987 HCl;Lanreotide Autogel;PNU-282987 (PNU282987);PNU-282987, 10 mM in DMSO;PNU 282987, alpha7 nAChR agonist;PNU 282987(PNU 282987 hydrochloride);PNU 282987 - CAS 123464-89-1 - Calbiochem
CBNumber: CB6847535
Molecular Formula: C14H17ClN2O
Formula Weight: 264.75058
MOL File: 123464-89-1.mol

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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Property

Melting point:: 240-242℃
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in DMSO (up to 25 mg/ml)
form: Off-white solid
color: White
Water Solubility: water: 100mM
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI: InChI=1/C14H17ClN2O/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17/h1-4,10,13H,5-9H2,(H,16,18)/t13-/s3
InChIKey: WECKJONDRAUFDD-VHLFKADZNA-N
SMILES: C(=O)(C1=CC=C(C=C1)Cl)N[C@@H]1[C@]2([H])CCN(CC2)C1 |&1:10,11,r|

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.05278
Product name: PNU 282987 - CAS 123464-89-1 - Calbiochem
Packaging: 10MG
Price: $153
Updated: 2022/05/15

Tocris

Product number: 2303
Product name: PNU282987
Purity: ≥98%(HPLC)
Packaging: 10
Price: $151
Updated: 2021/12/16

Tocris

Product number: 2303
Product name: PNU282987
Purity: ≥98%(HPLC)
Packaging: 50
Price: $634
Updated: 2021/12/16

Usbiological

Product number: 256295
Product name: PNU 282987
Packaging: 10mg
Price: $409
Updated: 2021/12/16

TRC

Product number: P653468
Product name: PNU282987
Packaging: 250mg
Price: $495
Updated: 2021/12/16

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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Chemical Properties,Usage,Production

Description

PNU 282987 (CAS 123464-89-1) is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist (Ki?= 26 nM).1? The?a7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimer’s, Parkinson’s, schizophrenia, and attention deficit disorders – agonism of this receptor with PNU 282987 has shown potential to ameliorate these deficits.2-5

Uses

PNU 282987 is used as an activator of α-7 nicotinic acetylcholine receptor.

General Description

A potent agonist highly selective for α7 nAChRs (K_i = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.

Biological Activity

Highly selective α 7 nAChR agonist (K i = 26 nM) displaying negligible blockade of α 1 β 1 γ δ and α 3 β 4 nAChRs (IC 50 ≥ 60 μ M). Found to be inactive against a panel of 32 receptors at 1 μ M, except 5-HT 3 receptors (K i = 930 nM).

Biochem/physiol Actions

Primary Targetα7 nAChRs

References

[1] ALICE L. BODNAR. Discovery and Structure−Activity Relationship of Quinuclidine Benzamides as Agonists of α7 Nicotinic Acetylcholine Receptors[J]. Journal of Medicinal Chemistry, 2005, 48 4: 905-908. DOI:10.1021/jm049363q
[2] VANESSA STUCKENHOLZ. The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice.[J]. Journal of Parkinson’s disease, 2013: 161-172. DOI:10.3233/jpd-120157
[3] PALOMA VICENS. Motor and anxiety effects of PNU-282987, an alpha7 nicotinic receptor agonist, and stress in an animal model of Alzheimer’s disease.[J]. Current Alzheimer research, 2013, 10 5: 516-523. DOI:10.2174/15672050113109990130
[4] ELISA NAVARRO . Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction[J]. Biochemical pharmacology, 2015, 97 4: Pages 473-481. DOI:10.1016/j.bcp.2015.07.022
[5] SAMANTHA L. MCLEAN . Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders[J]. Behavioural Brain Research, 2016, 302: Pages 73-80. DOI:10.1016/j.bbr.2015.08.037

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Suppliers

China 130 Germany 3 India 2 Switzerland 1 United Kingdom 3 United States 20 Global 159

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
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Angel Pharmatech, Ltd.

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Shanghai Boyle Chemical Co., Ltd.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Shanghai Sphchem Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

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UHN Shanghai Research & Development Co., Ltd.

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View Lastest Price from N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE manufacturers

Career Henan Chemical Co

Product: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide 123464-89-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-20

123464-89-1, N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDERelated Search:

Tamoxifen citrate REVERSINE (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT THIP HYDROCHLORIDE PNU-282987 S enantiomer hydrochloride Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- PNU-282987 (S enantiomer free base) 2-amino-N-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide 3-amino-N-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide 2-amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chlorobenzamide N1-(1-azabicyclo[2.2.2]oct-3-yl)-3-chlorobenzamide 5-amino-N-1-azabicyclo[2.2.2]oct-3-yl-2-chlorobenzamide 4-amino-N-1-azabicyclo[2.2.2]oct-3-yl-2-chlorobenzamide N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE

PNU 282987

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride PNU 282987

PNU282987 HCl

PNU 282987(PNU 282987 hydrochloride)

CS-1012

PNU 282987 - CAS 123464-89-1 - Calbiochem

SKL843

Lanreotide Autogel

(R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-, hydrochloride (1:1)

PNU 282987, alpha7 nAChR agonist

PNU-282987, 10 mM in DMSO

PNU-282987 (PNU282987)

4-chloro-n-((1s,3r,4s)-quinuclidin-3-yl)benzamide

123464-89-1

C14H17ClN2OHCl

Inhibitors

Acetylcholine receptor