N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE
- Product Name
- N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE
- CAS No.
- 123464-89-1
- Chemical Name
- N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE
- Synonyms
- SKL843;CS-1012;PNU 282987;PNU282987 HCl;Lanreotide Autogel;PNU 282987, alpha7 nAChR agonist;PNU 282987(PNU 282987 hydrochloride);PNU 282987 - CAS 123464-89-1 - Calbiochem;N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE;(R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride
- CBNumber
- CB6847535
- Molecular Formula
- C14H17ClN2O
- Formula Weight
- 264.75058
- MOL File
- 123464-89-1.mol
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Property
- Melting point:
- 240-242℃
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in DMSO (up to 25 mg/ml)
- form
- Off-white solid
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 5.05278
- Product name
- PNU 282987 - CAS 123464-89-1 - Calbiochem
- Packaging
- 10MG
- Price
- $153
- Updated
- 2022/05/15
- Product number
- J67353
- Product name
- PNU-282987, 99%
- Packaging
- 10mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- 2303
- Product name
- PNU282987
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 2303
- Product name
- PNU282987
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $634
- Updated
- 2021/12/16
- Product number
- P653468
- Product name
- PNU282987
- Packaging
- 250mg
- Price
- $495
- Updated
- 2021/12/16
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Chemical Properties,Usage,Production
Description
PNU 282987 (CAS 123464-89-1) is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist (Ki?= 26 nM).1? The?a7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimer’s, Parkinson’s, schizophrenia, and attention deficit disorders – agonism of this receptor with PNU 282987 has shown potential to ameliorate these deficits.2-5
Uses
PNU 282987 is used as an activator of α-7 nicotinic acetylcholine receptor.
General Description
A potent agonist highly selective for α7 nAChRs (Ki = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.
Biological Activity
Highly selective α 7 nAChR agonist (K i = 26 nM) displaying negligible blockade of α 1 β 1 γ δ and α 3 β 4 nAChRs (IC 50 ≥ 60 μ M). Found to be inactive against a panel of 32 receptors at 1 μ M, except 5-HT 3 receptors (K i = 930 nM).
Biochem/physiol Actions
Primary Targetα7 nAChRs
References
1) Bodnar?et al.?(2005),?Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors; J. Med. Chem.?48?905 2) Stuckenholz?et al.?(2013),?The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice; J. Parkinsons Dis.?3?161 3) Vicens?et al. (2013),?Motor and anxiety effects of PNU-282987, an alpha7 nicotinic receptor agonist, and stress in an animal model of Alzheimer’s disease; Curr. Alzheimer Res.?10?516 4) Navarro?et al.?(2015),?Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction; Biochem. Pharmacol.?97?473 5) McLean?et al.?(2016),?Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders; Behav. Brain Res.?302?73
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE manufacturers
- Product
- N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide 123464-89-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-20