ChemicalBook > CAS DataBase List > N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE

Product Name
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE
CAS No.
123464-89-1
Chemical Name
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE
Synonyms
SKL843;CS-1012;PNU 282987;PNU282987 HCl;Lanreotide Autogel;PNU 282987(PNU 282987 hydrochloride);PNU 282987 - CAS 123464-89-1 - Calbiochem;N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE;(R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride
CBNumber
CB6847535
Molecular Formula
C14H17ClN2O
Formula Weight
264.75058
MOL File
123464-89-1.mol
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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Property

Melting point:
240-242℃
storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble in DMSO (up to 25 mg/ml)
form 
Off-white solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05278
Product name
PNU 282987 - CAS 123464-89-1 - Calbiochem
Packaging
10MG
Price
$153
Updated
2022/05/15
Alfa Aesar
Product number
J67353
Product name
PNU-282987, 99%
Packaging
10mg
Price
$158
Updated
2021/12/16
Tocris
Product number
2303
Product name
PNU282987
Purity
≥98%(HPLC)
Packaging
10
Price
$151
Updated
2021/12/16
Tocris
Product number
2303
Product name
PNU282987
Purity
≥98%(HPLC)
Packaging
50
Price
$634
Updated
2021/12/16
TRC
Product number
P653468
Product name
PNU282987
Packaging
250mg
Price
$495
Updated
2021/12/16
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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Chemical Properties,Usage,Production

Description

PNU 282987 (CAS 123464-89-1) is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist (Ki?= 26 nM).1? The?a7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimer’s, Parkinson’s, schizophrenia, and attention deficit disorders – agonism of this receptor with PNU 282987 has shown potential to ameliorate these deficits.2-5

Uses

PNU 282987 is used as an activator of α-7 nicotinic acetylcholine receptor.

General Description

A potent agonist highly selective for α7 nAChRs (Ki = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.

Biological Activity

Highly selective α 7 nAChR agonist (K i = 26 nM) displaying negligible blockade of α 1 β 1 γ δ and α 3 β 4 nAChRs (IC 50 ≥ 60 μ M). Found to be inactive against a panel of 32 receptors at 1 μ M, except 5-HT 3 receptors (K i = 930 nM).

Biochem/physiol Actions

Primary Targetα7 nAChRs

References

1) Bodnar?et al.?(2005),?Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors; J. Med. Chem.?48?905 2) Stuckenholz?et al.?(2013),?The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice; J. Parkinsons Dis.?3?161 3) Vicens?et al. (2013),?Motor and anxiety effects of PNU-282987, an alpha7 nicotinic receptor agonist, and stress in an animal model of Alzheimer’s disease; Curr. Alzheimer Res.?10?516 4) Navarro?et al.?(2015),?Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction; Biochem. Pharmacol.?97?473 5) McLean?et al.?(2016),?Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders; Behav. Brain Res.?302?73

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Suppliers

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View Lastest Price from N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE manufacturers

Career Henan Chemical Co
Product
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide 123464-89-1
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

123464-89-1, N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDERelated Search:

Tamoxifen citrate REVERSINE (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT THIP HYDROCHLORIDE PNU-282987 S enantiomer hydrochloride Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- PNU-282987 (S enantiomer free base) 2-amino-N-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide 3-amino-N-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide 2-amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chlorobenzamide N1-(1-azabicyclo[2.2.2]oct-3-yl)-3-chlorobenzamide 5-amino-N-1-azabicyclo[2.2.2]oct-3-yl-2-chlorobenzamide 4-amino-N-1-azabicyclo[2.2.2]oct-3-yl-2-chlorobenzamide N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE

  • N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE
  • PNU 282987
  • N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride
  • N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride PNU 282987
  • PNU282987 HCl
  • PNU 282987(PNU 282987 hydrochloride)
  • CS-1012
  • PNU 282987 - CAS 123464-89-1 - Calbiochem
  • SKL843
  • Lanreotide Autogel
  • (R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride
  • Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-, hydrochloride (1:1)
  • 123464-89-1
  • C14H17ClN2OHCl
  • Inhibitors
  • Acetylcholine receptor