ChemicalBook > CAS DataBase List > TOS-ARG-OME HCL

TOS-ARG-OME HCL

Product Name
TOS-ARG-OME HCL
CAS No.
1784-03-8
Chemical Name
TOS-ARG-OME HCL
Synonyms
TAME;L-TAME;TAME,HCl;Tos-Arg-OMe;Tos-Arg-OMe¤HC;Ala-Ala-Ala-OMe;TOS-ARG-OME HCL;H-Tos-Arg-OMe·HCl;Tos-L-Arg-OMe*HCl;TAME HYDROCHLORIDE
CBNumber
CB2669913
Molecular Formula
C14H23ClN4O4S
Formula Weight
378.87
MOL File
1784-03-8.mol
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TOS-ARG-OME HCL Property

Melting point:
145-147(lit.)
alpha 
-14 º (c=4, H2O)
refractive index 
-14 ° (C=4, H2O)
storage temp. 
-20°C
solubility 
methanol: 50 mg/mL, clear, colorless
form 
Fine Crystalline Powder
color 
White
BRN 
3922357
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChIKey
JIQFFACVQXXHMY-YDALLXLXSA-N
CAS DataBase Reference
1784-03-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-37/39-26
WGK Germany 
3
F 
3-10
HS Code 
29252900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H224Extremely flammable liquid and vapour

H304May be fatal if swallowed and enters airways

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

H361Suspected of damaging fertility or the unborn child

H371May cause damage to organs

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P331Do NOT induce vomiting.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T4626
Product name
Nα-p-Tosyl-L-arginine methyl ester hydrochloride
Packaging
5g
Price
$61.9
Updated
2024/03/01
Sigma-Aldrich
Product number
172104
Product name
Anaphase-Promoting Complex Inhibitor, TAME
Packaging
50mg
Price
$85.2
Updated
2024/03/01
TCI Chemical
Product number
T0330
Product name
Nα-Tosyl-L-arginine Methyl Ester Hydrochloride
Purity
>98.0%(T)
Packaging
1g
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
T0330
Product name
Nα-Tosyl-L-arginine Methyl Ester Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
17550
Product name
N-4-Tosyl-L-arginine methyl ester (hydrochloride)
Purity
≥98%
Packaging
5g
Price
$44
Updated
2024/03/01
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TOS-ARG-OME HCL Chemical Properties,Usage,Production

Description

TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2

Chemical Properties

white fine crystalline powder

Uses

enzyme inhibitor

Uses

Substrate for trypsin, thrombin, plasmin and other proteases.

Uses

N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources.

Biochem/physiol Actions

Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.

References

1) Zeng et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage; Cancer Cell, 18 382 2) Zeng and King (2012) An APC/C inhibitor stabilizes Cyclin B1 by prematurely terminating ubiquitination; Nat. Chem. Biol., 8 383

TOS-ARG-OME HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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TOS-ARG-OME HCL Suppliers

Belgium 1 China 201 Europe 2 Germany 5 India 6 Japan 3 South Korea 1 Switzerland 5 United Kingdom 10 United States 45 USA 1 Global 280
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View Lastest Price from TOS-ARG-OME HCL manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Tos-Arg-OMe·HCl 1784-03-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Career Henan Chemical Co
Product
TOS-ARG-OME HCL 1784-03-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-16

1784-03-8, TOS-ARG-OME HCLRelated Search:

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  • N-ALPHA-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE SALT
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  • Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem
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  • P-Tosyl-L-ArginineMethylEster
  • TAME,HCl
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  • N<SUB>α</SUB>-p-Tosyl-L-arginine methyl ester hydrochloride
  • TAME ~-N-p-Tosyl-L-arginine methyl ester hydrochloride
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  • Methyl N-{2}-[(p-tolyl)sulfonyl]-L-argininate monohydrochloride.
  • P-Tosyl-l-arginine methyl ester HCL
  • N-alpha-p-Toluolsulfonyl-L-arginine methyl ester hydrochloride
  • Tos-L-Arg-OMe*HCl
  • NA-P-TOSYL-L-ARGININE METHYL*ESTER H
  • Tos-Arg-OMe¤HC