CLOPERASTINE

Product Name: CLOPERASTINE
CAS No.: 3703-76-2
Chemical Name: CLOPERASTINE
Synonyms: CLOPERASTINE;CLOPERASTINE USP/EP/BP;Cloperastine (base and/or unspecified salts);p-Chlorobenzhydryl2-(1-piperidyl)-ethyl ether;1-[2-[p-Chloro-phenylbenzyl)-oxy]ethy]piperidine;1-[2-(p-Chloro-α-phenylbenzyloxy)ethyl]piperidine;1-[2-[(p-Chloro-α-phenylbenzyl)oxy]ethyl]piperidine;1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)piperidine;1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)-piperidin;1-[2-[[4-Chloro-α-(phenyl)benzyl]oxy]ethyl]piperidine
CBNumber: CB2670438
Molecular Formula: C20H24ClNO
Formula Weight: 329.87
MOL File: 3703-76-2.mol

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CLOPERASTINE Property

Boiling point:: bp0.06 172-174°; bp0.15 178-180°
Density: 1.0383 (rough estimate)
refractive index: 1.5790 (estimate)
pka: 8.69±0.10(Predicted)

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Safety

Toxicity: LD50 unreported in guinea pig: 439mg/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C587215
Product name: Cloperastine
Packaging: 500mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008669
Product name: CLOPERASTINE
Purity: 95.00%
Packaging: 5MG
Price: $499.19
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008669
Product name: CLOPERASTINE
Purity: 95.00%
Packaging: 1G
Price: $1575
Updated: 2021/12/16

Alichem

Product number: 3703762
Product name: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine
Packaging: 1g
Price: $690.8
Updated: 2021/12/16

Chemenu

Product number: CM180441
Product name: 1-(2-((4-chlorophenyl)(phenyl)methoxy)ethyl)piperidine
Purity: 95%
Packaging: 1g
Price: $729
Updated: 2021/12/16

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CLOPERASTINE Chemical Properties,Usage,Production

Originator

Hustazol,Yoshitomi,Japan,1972

Uses

Cloperastine Hydrochloride (C587213) is an anti-tussive drug as an over-the-counter cold medicine.

Definition

ChEBI: 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine is a diarylmethane.

Manufacturing Process

The manufacture of a related compound is first described. 28.1 parts of pchloro-benzhydryl bromide are heated to boiling, under reflux and with stirring, with 50 parts of ethylene chlorohydrin and 5.3 parts of calcined sodium carbonate. The reaction product is extracted with ether and the ethereal solution washed with water and dilute hydrochloric acid. The residue
from the solution in ether boils at 134° to 137°C under 0.2 mm pressure and is p-chloro-benzhydryl-(β-chloroethyl)ether.
28.1 parts of this ether are heated with 12 parts of methylethylamine (100%) in a sealed tube for 4 hours at 110°C. The product of the reaction is extracted several times with dilute hydrochloric acid, the acid solution made alkaline, in the cold, with concentrated caustic soda solution and the base which separates taken up in ether. The ether extract is washed with concentrated potassium carbonate solution, evaporated down, and the residue distilled in vacuo. The product is β-methylethyl aminoethyl p-chlorobenzhydryl ether, BP 152° to 153°C/0.1 mm.
Reaction with dimethylethylamine instead of methylethylamine leads directly to a quaternary compound, which type of compound can also be obtained by reacting the tertiary aminoethyl ether with reactive esters
If 18 parts of piperidine are used instead of 12 parts of methylethylamine then the same procedure results in the formation of p-chloro-benzyhydril-(β- piperidino-ethyl)ether, boiling at 178° to 180°C under 0.15 mm pressure.

Therapeutic Function

Antitussive

CLOPERASTINE Preparation Products And Raw materials

Raw materials

Diphenyl Piperidine 2-Chloroethanol 4-Chlorobenzhydrol Sodium carbonate

Preparation Products

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CLOPERASTINE Suppliers

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View Lastest Price from CLOPERASTINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Cloperastine 3703-76-2
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-08

Hebei Mojin Biotechnology Co., Ltd

Product: CLOPERASTINE 3703-76-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-01

Jiangsu Boquan Biotechnology Co., Ltd.

Product: Cloperastine 3703-76-2
Price: US $102.00-88.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10kg
Release date: 2023-02-21

3703-76-2, CLOPERASTINERelated Search:

Cloperastine fendizoate CLOPERASTINE HYDROCHLORIDE,CLOPERASTINE HCL

CLOPERASTINE

1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)-piperidin

1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)piperidine

1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidin

1-(2-[(4-Chlorophenyl)(phenyl)methoxy]ethyl)piperidine

1-[2-[p-Chloro-phenylbenzyl)-oxy]ethy]piperidine

1-{2-[(p-Chloro-alpha-phenylbenzyl)oxy]ethyl}piperidine

Piperidine, 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-

Piperidine, 1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]-

p-Chlorobenzhydryl2-(1-piperidyl)-ethyl ether

Cloperastine (base and/or unspecified salts)

1-[2-(p-Chloro-α-phenylbenzyloxy)ethyl]piperidine

1-[2-[(p-Chloro-α-phenylbenzyl)oxy]ethyl]piperidine

1-[2-[[4-Chloro-α-(phenyl)benzyl]oxy]ethyl]piperidine

CLOPERASTINE USP/EP/BP

3703-76-2

C20H24ClNO