4-HYDROXYPHENYLRETINAMIDE

Product Name: 4-HYDROXYPHENYLRETINAMIDE
CAS No.: 65646-68-6
Chemical Name: 4-HYDROXYPHENYLRETINAMIDE
Synonyms: hpr;4HPR;MK-4016;RETINAMIDE;CNTFRalpha;FENRETINIDE;Fenretinimide;Fenretinide(4-HPR);Fenretinide, >=98%;p-Hydroxyphenylretinamide
CBNumber: CB2680860
Molecular Formula: C26H33NO2
Formula Weight: 391.55
MOL File: 65646-68-6.mol

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4-HYDROXYPHENYLRETINAMIDE Property

Melting point:: 162-163°C
Boiling point:: 597.6±42.0 °C(Predicted)
Density: 1.081±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Orange solid
pka: 9.98±0.26(Predicted)
color: Yellow
λmax: 362nm(MeOH)(lit.)
Merck: 14,3998
Stability:: Light Sensitive - Protect from Light Exposure
InChIKey: AKJHMTWEGVYYSE-FXILSDISSA-N
CAS DataBase Reference: 65646-68-6(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 60-61-20/21/22-36/37/38
Safety Statements: 53-26-36/37/39-45-52
WGK Germany: 3
RTECS: VH6420000
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SAB1301585
Product name: ANTI-HPR (CENTER) antibody produced in rabbit
Purity: IgG fraction of antiserum, buffered aqueous solution
Packaging: 400μl
Price: $481
Updated: 2024/03/01

Sigma-Aldrich

Product number: H7779
Product name: Retinoic acid p-hydroxyanilide
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $212
Updated: 2024/03/01

Sigma-Aldrich

Product number: 390900
Product name: 4-Hydroxyphenylretinamide
Purity: A synthetic amide of all-
Packaging: 5mg
Price: $216
Updated: 2024/03/01

TCI Chemical

Product number: H1464
Product name: all-trans-N-(4-Hydroxyphenyl)retinamide
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $174
Updated: 2024/03/01

TCI Chemical

Product number: H1464
Product name: all-trans-N-(4-Hydroxyphenyl)retinamide
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $693
Updated: 2024/03/01

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4-HYDROXYPHENYLRETINAMIDE Chemical Properties,Usage,Production

Chemical Properties

4-HYDROXYPHENYLRETINAMIDE is Yellow Powder

Uses

4-HYDROXYPHENYLRETINAMIDE is an effective agent for the chemoprevention and growth modulation of oncogene-induced prostate cancer in the mouse prostate reconstitution model system and may be effective for the chemoprevention of human prostate cancer

Uses

A synthetic analog of Vitamin A.

Uses

Retinoic acid receptor ligand

Definition

ChEBI: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in ivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

General Description

Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.

Biological Activity

Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo . Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

Biochem/physiol Actions

Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.

storage

Store at -20°C

References

[1] roberto benelli, stefano monteghirfo, roberta venè, francesca tosettiand nicoletta ferrari.the chemopreventive retinoid 4hpr impairs prostate cancer cell migration and invasion by interfering with fak/akt/gsk3β pathway andβ-catenin stability. molecular cancer.2010, 9:142-154.
[2] anita l. sabichi, denver t. hendricks, mary a. bober, michael j. birrer. retinoic acid receptorβexpression and growthinhibition of gynecologic cancer cells by thesynthetic retinoidn-(4-hydroxyphenyl) retinamide. journal of the national cancer institute. 1998, 90(8): 597-605.
[3] shi-yong sun, ping yue, and reuben lotan. induction of apoptosis by n-(4-hydroxyphenyl)retinamide andits association with reactive oxygen species, nuclearretinoic acid receptors, and apoptosis-related genes in human prostate carcinoma cells.molecular pharmacology. 1999, 55:403–410.

4-HYDROXYPHENYLRETINAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXYPHENYLRETINAMIDE Suppliers

Americas 1 Canada 1 China 161 Europe 1 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 10 United States 31 Global 213

Carbosynth

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MOLEKULA Ltd.

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CARBONE SCIENTIFIC CO.,LTD

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ETA SCIENTIFIC Co.,Ltd

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UK GREEN SCIENTIFIC CO.,LIMITED

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VWR International

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View Lastest Price from 4-HYDROXYPHENYLRETINAMIDE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Fenretinide 65646-68-6
Price: US $16.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 3kg
Release date: 2022-01-10

Career Henan Chemical Co

Product: 4-HYDROXYPHENYLRETINAMIDE 65646-68-6
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

65646-68-6, 4-HYDROXYPHENYLRETINAMIDERelated Search:

2-Chloro-5-iodobenzoic acid Retinal 4-HYDROXYPHENYLRETINAMIDE N-(4-CARBETHOXYPHENYL)RETINAMIDE,n-(4-ethoxycarbophenyl)retinamide,4-(carboethoxyphenyl)retinamide retinamide N-4-METHOXYPHENYLRETINAMIDE N-homocysteine thiolactonyl retinamide DECA-2,4,6,8-TETRAENAL METHOXY PEG-12 RETINAMIDE N-phenylretinamide N-(4-aminosulfonylphenyl)retinamide N-(2-HYDROXYPROPYL)RETINAMIDE 4-HYDROXYPHENYLRETINAMIDE--N N-(2-hydroxyethyl)retinamide N-(4-PIVALOYLOXYPHENYL)RETINAMIDE N-(3-HYDROXYPROPYL)RETINAMIDE RETINAMIDE,N-ETHYL- N-(2,3-DIHYDROXYPROPYL)RETINAMIDE

4-HYDROXYPHENYLRETINAMIDE

4HPR

FENRETINIDE

p-Hydroxyphenylretinamide

4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide

(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenamide

Fenretinimide

Fenretinide(4-HPR)

RetinaMide,N-(4-hydroxyphenyl)-

Fenretinide N-(4-Hydroxyphenyl)retinamide

ANTI-HPR (CENTER) antibody produced in rabbit

all-trans-N-(4-Hydroxyphenyl)retinamide

Fenretinide, >=98%

N-(4-HYDROXYPHENYL)-ALL-TRANS RETINAMIDE

N-(4-HYDROXYPHENYL)RETINAMIDE

RETINOIC ACID P-HYDROXYANILIDE

RETINAMIDE

hpr

n-(4-hydroxyphenyl)-retinamid

4-HPR; (4-HYDROXYPHENYL)RETINAMIDE

4-Hydroxyphenylretinamide - CAS 65646-68-6 - Calbiochem

(2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenamide

CNTFRalpha

all-trans-N-(4-Hydroxyphenyl)retinamide &gt

MK-4016

Fenretinide D4Q: What is Fenretinide D4 Q: What is the CAS Number of Fenretinide D4 Q: What is the storage condition of Fenretinide D4 Q: What are the applications of Fenretinide D4

65646-68-6

C26H33NO2

Cell Biology

Gene Regulation and Expression

PPAR and RXR Regulators

Cell Signaling and Neuroscience

BioChemical

Intracellular receptor

Intermediates & Fine Chemicals

Pharmaceuticals

Retinoids

Drug Analogues

Inhibitors