2-Methylene-1,3-propanediol
Application- Product Name
- 2-Methylene-1,3-propanediol
- CAS No.
- 3513-81-3
- Chemical Name
- 2-Methylene-1,3-propanediol
- Synonyms
- 2-Methylene-1;2-methylene-3-propanediol;1-（4-pyridinyl) acetone;2-methylenepropane-1,3-diol;2-METHYLENE-1,3-PROPANEDIOL;2-Methylidenepropane-1,3-diol;1,3-Propanediol, 2-methylene-;2-Methylene-1,3-propanediol>2-Methylene-1,3-propanediol 97%;2-METHYLENE-1,3-PROPANEDIOL,97+%
- CBNumber
- CB2684161
- Molecular Formula
- C4H8O2
- Formula Weight
- 88.11
- MOL File
- 3513-81-3.mol
2-Methylene-1,3-propanediol Property
- Boiling point:
- 93-95 °C/2 mmHg (lit.)
- Density
- 1.081 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.473(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 14.14±0.10(Predicted)
- form
- Viscous Liquid
- color
- Clear colorless to pale yellow
- BRN
- 1737653
- InChI
- InChI=1S/C4H8O2/c1-4(2-5)3-6/h5-6H,1-3H2
- InChIKey
- JFFYKITVXPZLQS-UHFFFAOYSA-N
- SMILES
- C(O)C(=C)CO
- CAS DataBase Reference
- 3513-81-3(CAS DataBase Reference)
- EPA Substance Registry System
- 1,3-Propanediol, 2-methylene- (3513-81-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 339512
- Product name
- 2-Methylene-1,3-propanediol
- Purity
- 97%
- Packaging
- 5g
- Price
- $133.95
- Updated
- 2025/07/31
- Product number
- M2473
- Product name
- 2-Methylene-1,3-propanediol
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- M2473
- Product name
- 2-Methylene-1,3-propanediol
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- B494823
- Product name
- 2-Methylene-1,3-propanediol
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- JK193879
- Product name
- 2-Methylene-1,3-propanediol
- Purity
- 97%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
2-Methylene-1,3-propanediol Chemical Properties,Usage,Production
Application
2-Methylene-1,3-propanediol, commonly known as isobutylene glycol, can be used to synthesize platelet-active factor inhibitors due to its unique methylene branched structure; it is also a crosslinking agent that can esterify with alkyd and polyester resins, effectively improving the thermal stability of polymers.
Chemical Properties
clear colorless to pale yellow viscous liquid
Synthesis
3775-29-9
3513-81-3
General procedure for the synthesis of 2-methylene-1,3-propanediol from 2-methylenepropane-1,3-diyl diacetate: allyl alcohol (1 eq.) was dissolved with acetic anhydride (1.2 eq.) in dichloromethane (DCM, concentration ca. 1 M) at 0 °C. Subsequently, pyridine (1 eq.) and 4-dimethylaminopyridine (DMAP, 0.1 mol%) were added to the reaction system. The reaction mixture was kept stirred at 0 °C for 30 min and then gradually warmed up to room temperature. After completion of the reaction, the reaction was quenched with 2N hydrochloric acid solution, the organic layer was separated, washed sequentially with water and brine and finally dried with anhydrous sodium sulfate. The solvent was removed by careful evaporation under reduced pressure to give pure 2-methylene propane-1,3-diyl diacetate (2d) without further purification. Subsequent processing was carried out via Method B. Specifically, purification by column chromatography (eluent ratio hexane:ethyl acetate = 20:1) afforded 2-methylene-1,3-propanediol as a colorless oil (20 g, 91% yield). The analytical data of the resulting compound were in agreement with literature reports.
References
[1] Patent: WO2018/53322, 2018, A1. Location in patent: Paragraph 0090; 00143
[2] J. Appl. Chem. USSR (Engl. Transl.), 1988, vol. 61, # 4, p. 853 - 855
[3] Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1988, vol. 61, # 4, p. 934 - 937
[4] Synlett, 2008, # 15, p. 2321 - 2325
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View Lastest Price from 2-Methylene-1,3-propanediol manufacturers
- Product
- 2-Methylene-1,3-propanediol 3513-81-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
- Product
- 2-Methylene-1,3-propanediol 3513-81-3
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-17
- Product
- 2-Methylene-1,3-propanediol 3513-81-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2019-08-31